Accelerated aging of fasted Drosophila Preservation of Physiological function and cellular fine structure by thiazolidine carboxylic acid (TCA)

Oxidative stress, aging and longevity in Drosophila melanogaster

“…Antioxidants were reported to increase longevity in some studies, but not in others (Table 1 ). It is unfortunate that other traits have not always been studied, because antioxidants can have deleterious effects on traits [9–11] that, as a consequence, increase longevity. For instance, thioproline was reported to increase longevity [12,13] and mating ability at old age [12], but also to decrease metabolic rate, mean weight at eclosion and development speed [9].…”

“…It is unfortunate that other traits have not always been studied, because antioxidants can have deleterious effects on traits [9–11] that, as a consequence, increase longevity. For instance, thioproline was reported to increase longevity [12,13] and mating ability at old age [12], but also to decrease metabolic rate, mean weight at eclosion and development speed [9]. Compounds other than antioxidants can also increase longevity: urea, a toxic metabolic waste of flies, increases longevity of mated flies, but not of virgin ones [14].…”

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

“…NDGA also extends median lifespan in evolutionarily distant organisms, such as fruit flies (by 12%) and mosquitoes (by 50%). 7,8 Several studies also showed the effects of NDGA on neurodegenerative disorders. In a fruit fly model of Parkinson’s disease, NDGA delayed the loss of climbing ability associated with onset of neurodegeneration.…”

The fine structural morphology of the midgut of aged drosophila: A morphometric analysis

“…NUMEROUS INVESTIGATORS have reported age-related fine structural alterations in various organs of several insects (see Lamb, 1978;Sohal and McArthur, 1985;Sohal, 1985;Baker et al, 1985;Gartner, 1986). Some of these included flight muscle (Rockstein and Bhatnagar, 1965;Simon et al, 1969;Takahashi et al, 1970;Sohal and Allison, 1971;Sacktor and Shimada, 1972;Sohal et al, 1972;Sohal, 1976;Chesky, 1978;Shafiq, 1979, 1981;Collatz and Collatz, 1981;Economos et al, 1982), heart (Sohal, 1970(Sohal, , 1978Butch et al, 1970;Cruz-Landim, 1976;Collatz and Collatz, 1981), brain (Sohal and Donato, 1979;Collatz and Collatz, 1981;Kern and Wegener, 1984), midgut (Gartner, 1970(Gartner, , 1973Gartner and Gartner, 1976;Anton-Erxleben et al, 1983) and malpighian tubules (Miquel, 1971;Sohal and Lamb, 1979;Collatz and Collatz, 1981). Most of the alterations involved mitochondrial size and number, cytoplasmic and nuclear inclusions, and the accumulation of virus-like particles.…”