Oxidative stress, aging and longevity in <i>Drosophila melanogaster</i>

Bourg, Éric Le

doi:10.1016/s0014-5793(01)02457-7

Cited by 113 publications

(50 citation statements)

References 41 publications

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“…Le Rohellec and Le Bourg (2009) thus reported some positive effects of suppressing live yeast on longevity, contrarily to previous studies of the same laboratory using other DR methods (Le Bourg and Médioni 1991;Le Bourg and Minois 1996), and on behavioral aging, but they also showed that DR increased frailty. Thus, suppressing live yeast has both positive and negative effects.…”

Section: Introductionsupporting

confidence: 52%

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Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster

Bourg

2009

Biogerontology

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A cold pretreatment has various positive effects on aging, longevity, and resistance to some stresses in Drosophila melanogaster flies. Removing live yeast from food has either favorable or deleterious effects on these traits. This study combined a cold pretreatment and removal of live yeast in the same flies, in order to know whether higher favorable effects would be observed with this combination than with each treatment alone. Each treatment had positive effects on climbing activity and their combination had additive effects, thus giving the highest climbing scores in flies subjected to the two treatments and the lowest ones in flies with live yeast and no cold pretreatment. Therefore, combining the two treatments had favorable effects if each of them had favorable effects. When removing live yeast had very deleterious effects, as on resistance to cold, a cold pretreatment was unable to reverse these effects, which was not unexpected. Finally, when removal had no effect or not a tragic negative effect, as on resistance to infection or to heat, a cold pretreatment was neutral or slightly compensated the negative effects of live yeast removal. These results lead to the conclusion that next studies using a combination of two mild stresses having beneficial effects on aging and longevity could bring more positive effects than each mild stress alone.

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Section: Introductionsupporting

confidence: 52%

“…Contrasting effects of DR on longevity have been reported in D. melanogaster. Intermittent feeding did not increase longevity (Kopec 1928;Le Bourg and Médioni 1991). Dilution of a rearing medium containing dry yeast had no effect on longevity (David et al 1971;Soh et al 2008) or increased it (e.g.…”

Section: Introductionmentioning

confidence: 99%

Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster

Bourg

2009

Biogerontology

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“…Such compounds might also have adverse secondary effects that would limit their clinical use in the treatment of aging. As discussed in a review by Le Bourg, the potential secondary effects of antioxidants have been evaluated in a few studies (LeBourg 2001). To date, anti-aging studies have not systematically evaluated the secondary adverse effects of potential anti-aging compounds.…”

Section: Introductionmentioning

confidence: 99%

Pioglitazone: an anti-diabetic compound with anti-aging properties

et al. 2007

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Insulin and Insulin-Growth-Factor-like (IGF) signaling pathways are well known longevity pathways in nematodes, insects and mammals. To our knowledge, there are no systematic pharmacological studies evaluating the anti-aging properties of medications that target this pathway in Drosophila. Although there are no published data implicating an anti-aging role for these compounds in Drosophila, we hypothesized that their promising pharmacological profile might decrease mortality. However, the decrease in mortality could be due to a number of potential artifacts and confounds such as fecundity depression, decrease in metabolic rate, or CNS depression. Therefore, the mere finding that a compound decreases mortality does not qualify it as an anti-aging compound. In this study, we evaluated the anti-aging properties of four compounds that might target the insulin signaling pathway in Drosophila. Once it was established that the compound decreased mortality, we proceeded to evaluate possible confounding factors that could have contributed to the mortality reduction. We show that only piolglitazone displayed anti-aging properties. At present, we do not have a mechanistic explanation for this pharmacological disparity.

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“…For example, the powerful ROS neutralizers coenzyme Q 10 and alpha-lipoic acid (ALA) fail to extend lifespan of mice (Lee et al 2004). Such contradictory results with even negative effects on longevity are also described for a variety of antioxidant compounds tested in the fruit fly, as summarized in Le Bourg (2001). Among the popular antioxidants, Driver and Georgeou (2003) discuss the variability associated with the effects of vitamin E on Drosophila lifespan.…”

Section: Antioxidantsmentioning

confidence: 99%

Oxidative damage, aging and anti-aging strategies

Haenold

Wassef

Heinemann

et al. 2005

AGE

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The last two decades brought remarkable insight into the nature of normal aging in multicellular organisms. However, we are still far away from realizing extension of maximum lifespan in humans. An important modulator of lifespan is oxidative damage induced by reactive species, such as reactive oxygen species (ROS). Studies from yeast, Caenorhabditis and Drosophila primarily focused on (1) reduced generation or (2) elimination of ROS but have two principal shortcomings: (1) dietary restriction and single gene mutations are often associated with physiological impairments and (2) overexpression of components of the antioxidant system extend lifetime only under stress-induced conditions. Recent results from Drosophila indicate the involvement of an endogenous repair and elimination system for oxidatively damaged proteins in the process of aging. This system includes methionine sulfoxide reductase A (MSRA) and the carbonyl reductase Sniffer, the protein-ubiquitin ligase Parkin and the chaperone Hsp22. In this review we summarize different anti-aging strategies and discuss a synergistic interaction between protection against free radicals and specific repair/elimination of oxidative damage in lifespan extension primarily using the model system Drosophila. To achieve lifespan extension, available experiments are often methodically grouped into (1) caloric restriction, (2) single gene mutation, and (3) overexpression of genes. Here we summarize different strategies by a more causal classification: (1) prevention of ROS generation, (2) reducing free ROS level, and (3) repair and elimination of ROS-damaged proteins.

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Oxidative stress, aging and longevity in Drosophila melanogaster

Cited by 113 publications

References 41 publications

Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster

Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster

Pioglitazone: an anti-diabetic compound with anti-aging properties

Oxidative damage, aging and anti-aging strategies

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