Acaricidal effects of fluazuron (2.5 mg/kg) and a combination of fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), administered at different routes, against Rhipicephalus (Boophilus) microplus parasitizing cattle

Gomes, Lucas Vinícius Costa; Lopes, Welber Daniel Zanetti; Cruz, Breno Cayeiro; Teixeira, Weslen Fabrício Pires; Felippelli, Gustavo; Maciel, W. J.; Bichuette, Murilo Abud; Ruivo, Maycon Araújo; Colli, Marcos Henrique Alcântara; Carvalho, Rodrigo Furtado de; Martinez, Antônio Campanha; Soares, Vando Edésio; Costa, Alvimar José da

doi:10.1016/j.exppara.2015.02.004

Cited by 30 publications

(17 citation statements)

References 22 publications

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“…Although diflubenzuron resistance has been previously reported in the Australian blow fly Lucilia cuprina (KOTZE & SALES, 2001;LEVOT & SALES, 2002), resistance of R. microplus to this insecticide has not been reported so far. It is also important to highlight that pour-on fluazuron (a compound in the same family as diflubenzuron) has been shown to have elevated therapeutic and residual efficacy (≥ 90%) on farms where the R. microplus strain was the same as the one used for stall tests in the present study (CRUZ et al, 2014;GOMES et al, 2015;MACIEL et al, 2016;LOPES et al, 2017).…”

Section: Discussionmentioning

confidence: 74%

“…The route of administration for benzoylphenylureas is a significant factor in relation to the effect of a particular active component (GOMES et al, 2015). Against R. microplus, the efficacy indexes for pour-on fluazuron are higher than 90% (CRUZ et al, 2014;GOMES et al, 2015;MACIEL et al, 2016;LOPES et al, 2017), which contrasts with efficacy rates of less than 50%for this same molecule administered through the subcutaneous route (GOMES et al, 2015), against the same strain of R. microplus. The same may have occurred for diflubenzuron administered via mineral salt, though further studies should be conducted to substantiate this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…However, the increasing number of R. microplus populations that are resistant to active agents in these chemical groups (CORRÊA et al, 2015;CRUZ et al, 2015;MACIEL et al, 2016) has led to decreases in their efficacy. In their place, treatments with benzoylphenyl ureas are increasingly being used (CRUZ et al, 2015;GOMES et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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In vivo effect of diflubenzuron, administered via mineral salt supplementation, against Haematobia irritans and Rhipicephalus microplus parasitizing cattle

Cruz

Gomes

Maciel

et al. 2018

Rev. Bras. Parasitol. Vet.

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This study involved two field trials with the aim of evaluating the efficacy of diflubenzuron, via mineral supplementation, against Haematobia irritans parasitizing cattle. Concomitantly with the main trial, a stall test was conducted to ascertain the effects of a different formulation with the same active ingredient against Rhipicephalus microplus, along with the action of diflubenzuron on the reproductive parameters of R. microplusfemales that had naturally detached from cattle. Against H. irritans, it was observed that the efficacy indexes fordiflubenzuron were low (≤ 31.3% or 44.6%) or null (0.0%) throughout the study. The anti- R. microplus efficacy of diflubenzuron, at weekly intervals, ranged from 0.0 to 13.7% over the entire experimental period. Null efficacy (0.0%) was registered for diflubenzuron in relation to the reproductive parameters of R. microplusfemales that had naturally detached from cattle. The different diflubenzuron formulations, administered via mineral salt supplementation, did not show satisfactory efficacy indexes against H. irritans and R. microplus parasitizing cattle, within the experimental design of the present study. In addition, this agent did not present any deleterious effects on the reproductive parameters of R. microplus females.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

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In vivo effect of diflubenzuron, administered via mineral salt supplementation, against Haematobia irritans and Rhipicephalus microplus parasitizing cattle

Cruz

Gomes

Maciel

et al. 2018

Rev. Bras. Parasitol. Vet.

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“…Sua eficácia no controle de R. microplus é observada a partir de duas semanas após o tratamento (Bull et al, 1996;Gomes et al, 2015).…”

Section: Discussionunclassified

Eficácia carrapaticida e preventiva sobre Rhipicephalus microplus da associação de abamectina com fluazuron em bovinos artificialmente infestados

Coelho¹,

Campos²,

Avelar³

et al. 2017

Braz. J. Vet. Med.

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Copyright Rocha et al. Este é um artigo publicado em acesso aberto (Open Access) sob a licença Creative Commons Attribution Non-Commercial, que permite uso, distribuição e reprodução em qualquer meio, sem restrições desde que sem fins comerciais e que o trabalho original seja corretamente citado.Eficácia carrapaticida e preventiva sobre Rhipicephalus microplus da associação de abamectina com fluazuron em bovinos artificialmente infestados resumo O objetivo deste trabalho foi avaliar a eficácia carrapaticida e preventiva da associação de abamectina 0,6% com fluazuron 3,0% em bovinos artificialmente infestados. Foram selecionados 12 bovinos, mantidos estabulados, mestiços das raças Gir x Holandês, machos, compondo seis animais por grupo. Os animais do grupo controle não receberam nenhum tipo de tratamento, enquanto que os animais do grupo tratado receberam a formulação da associação na dose única de 600 mcg de abamectina com 3 mg de fluazuron por quilo de peso corporal, por meio de via "pour-on". As infestações, dos grupos controle e tratado, foram realizadas com 2.500 larvas de Rhipicephalus microplus, nos dias -23, -21, -19, -17, -15, -13, -11, -9, -7, -5, -3, -2, -1 e a coleta de teleóginas foi realizada diariamente, dos dias -3 ao +91. Para a avaliação da eficácia preventiva, as infestações prosseguiram nos dias +7, +14, +21,+28, +35, +42, +49, +56, +63, +70 e a coleta de teleóginas seguiu diariamente até o dia +94. A eficácia contra a reinfestação foi calculada nos dias +7, +14, +21, +28, +35, +42 +49, +56, +63 e +70. A análise estatística entre as médias de teleóginas recuperadas entre os grupos controle e tratado demonstrou que ocorreu diferença significativa (p≤0,05) para todas as tomadas de tempo posteriores ao tratamento. O produto em teste apresentou resultados de eficácia carrapaticida de 0,00%; 6,81%; 62, 64%; 85,11%; 98,38%; 97,38%; 96,84%; 97,63%; 98,14%; 97,32%; 97,54%; 98,11%; 99,22%; 97,93%; 98,13%; 96,78%; 96,17%; 99,05%; 98,57%; 98,59%; 97,23%; 96,10%; 99,31% respectivamente para os dias experimentais +1, +2, +3, +4, +5, +6, +7, +8, +9, +10, +11, +12, +13, +14, +15, +16, +17, +18, +19, +20, +21, +22, +23 para o grupo tratado. A média da eficácia ao longo dos 23 dias após o tratamento foi de 97,8%. O resultado da eficácia preventiva foi de 98,12%; 98,68%; 98,36%; 97,88%; 96,76%; 96,45%; 96,84%; 97,03%; 95,36% e 87,07% respectivamente para os dias experimentais +7, +14, +21, +28, +35, +42, +49, +56, +63, +70. A associação de abamectina 0.6% com fluazuron 3.0% foi eficaz na prevenção contra a reinfestação por larvas de R. microplus por até 60 dias pós-tratamento.Palavras-chave: controle, Rhipicephalus microplus, ruminantes. AbstractThe purpose of the research was to evaluate the acaricide and preventive efficacy of association abamectina 0.6% and fluazuron 3.0% in control of Rhipicephalus microplus in artificial infestations cattle.Were selected 12 cattle, that were kept stabled, crossbreeds Gir x Dutch, males, composing six animals per group. The control group animals received no treatment, whi...

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“…The main tool available to control this ectoparasite is the use of synthetic chemical compounds (acaricides) (Pereira et al, 2008). In accordance with Cruz et al (2015) and Gomes et al (2015), the control of this ectoparasite using these chemical products is a key factor in improving production, but efforts to combat ticks on most cattle farms are performed incorrectly and are characterized by the excessive and disordered use of therapeutic approaches. In turn, this excessive usage increases production costs and accelerates the selection of parasite resistance, which represents a very significant (if not the primary) economic issue in animal production (Corrêa et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Ten years later: Evaluation of the effectiveness of 12.5% amitraz against a field population of Rhipicephalus (Boophilus) microplus using field studies, artificial infestation (Stall tests) and adult immersion tests

Maciel

Lopes

Cruz

et al. 2015

Veterinary Parasitology

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Using field trials, artificial infestations (Stall tests) and in vitro adult immersion tests, the present study evaluated the acaricidal efficacy of 12.5% amitraz administered via whole body spraying against a Rhipicephalus (Boophilus) microplus population that did not have any contact with chemical products belonging to this acaricide family for 10 years (approximately 40 generations). Two natural infestation trials, two artificial infestation trials (Stall tests) and two adult immersion tests were performed in two different stages in 2005 and 2015. Between 2002 and 2015, the bovine herd of this property was formed by approximately 450 animals from the Simmental breed that were divided into nine paddocks formed by Cynodon dactylon (L.) Pers. For the natural infestation experiments in 2005 and 2015, we selected nearly 70 animals naturally infested with ticks from the same herd that belonged to the "São Paulo" farm located in São José do Rio Pardo, São Paulo, Brazil. Field studies were performed in the same paddock (9). To evaluate anti-R. (B.) microplus activity in the artificially infested cattle (Stall tests) and adult immersion tests, two experiments of each methodology were performed at CPPAR (the Center of Research in Animal Health located on the FCAV/UNESP campus in Jaboticabal, São Paulo, Brazil) in 2005 and 2015. R. (B.) microplus used in the artificial infestation, and adult immersion test experiments were obtained from paddocks 1-9 in 2005 and 2015 from the commercial farm where the field studies were performed. Based on the obtained results, it was possible to conclude that amitraz use in rotation with pyrethroids every 28 days for three consecutive years (2002-2004) previous to the beginning of the first trial (2005) was sufficient to generate a R. (B.) microplus strain resistant to amitraz. Moreover, using field trials, artificial infestations (Stall tests) and adult immersion tests, we verified that 40 generations of the tick species with no contact to the aforementioned compound (amitraz) were not sufficient to revert or modify the efficacy/resistance of amitraz for this analyzed R. (B.) microplus strain. The reversion of amitraz efficacy values in R. (B.) microplus may only occur when resistance of the field strain is incipient. Alternatively, the differences in the results may be due to differences in the Rhipicephalus spp. species between current study locations. Therefore, future studies must be performed to prove this hypothesis.

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Acaricidal effects of fluazuron (2.5 mg/kg) and a combination of fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), administered at different routes, against Rhipicephalus (Boophilus) microplus parasitizing cattle

Cited by 30 publications

References 22 publications

In vivo effect of diflubenzuron, administered via mineral salt supplementation, against Haematobia irritans and Rhipicephalus microplus parasitizing cattle

In vivo effect of diflubenzuron, administered via mineral salt supplementation, against Haematobia irritans and Rhipicephalus microplus parasitizing cattle

Eficácia carrapaticida e preventiva sobre Rhipicephalus microplus da associação de abamectina com fluazuron em bovinos artificialmente infestados

Ten years later: Evaluation of the effectiveness of 12.5% amitraz against a field population of Rhipicephalus (Boophilus) microplus using field studies, artificial infestation (Stall tests) and adult immersion tests

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