Acaricidal activity of essential oils from Lippia alba genotypes and its major components carvone, limonene, and citral against Rhipicephalus microplus

Peixoto, Magna Galvão; Costa-Júnior, Lívio Martins; Blank, Arie Fitzgerald; Lima, Aldilene da Silva; Menezes, Thays Saynara Alves; Santos, Darlisson de Alexandria; Alves, Péricles Barreto; Cavalcanti, Sócrates Cabral de Holanda; Bacci, Leandro; Arrigoni-Blank, Maria de Fátima

doi:10.1016/j.vetpar.2015.03.010

Cited by 87 publications

(43 citation statements)

References 20 publications

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“…L. alba has been characterized by its remarkable morphological, phytochemical and genetic variations (Manica-Cattani et al, 2009;Jezler et al, 2013;Reis et al, 2014), as well as its economic importance and medicinal properties (Hennebelle et al, 2008). Biological characteristics such as toxicity repellency, antifungal, antibacterial, and antioxidant properties have been identified in essential oils or extracts of L. alba that are widely used in folk medicine (Glamočlija et al, 2011;Chies et al, 2013;Peixoto et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Induction of Synthetic Polyploids and Assessment of Genomic Stability in Lippia alba

et al. 2020

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Polyploidy is widely recognized as a major evolutionary force in plants and has been reported in the genus Lippia (Verbenaceae). Lippia alba, the most studied species, has been documented as a polyploid complex involving at least four ploidal levels. L. alba presents remarkable chemical and genetic variation and represents a model for understanding genome organization. Although the economic and medicinal importance of the species has been widely described, no established polyploid induction protocol has been reported so far. Here, we describe the production of synthetic polyploid plants of L. alba using colchicine. The ploidal levels were estimated by flow cytometry and chromosome counting. In addition, FISH and molecular markers approaches were used to confirm the stability of the synthetic polyploids. The major component of the essential oils was estimated by GCMS to compare with the natural individuals. Tetraploids and triploids were produced providing new opportunities for investigating medicinal, pharmacological, and economic applications as well as addressing intrinsic questions involved in the polyploidization process in tropical plants.

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Section: Introductionmentioning

confidence: 99%

Induction of Synthetic Polyploids and Assessment of Genomic Stability in Lippia alba

et al. 2020

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“…Acaricidal formulations of plant extracts are an alternative for SCFT control (Apel et al, 2009;Borges et al, 2011;Lebouvier et al, 2013;Castro et al, 2014;Lima et al, 2014;Peixoto et al, 2015). Natural plant extracts can be safer to use than SCA because they tend to degrade quickly in the environment and the reduced risk for chemical residues in beef and milk (Hernandez et al, 1987;Gupta et al, 2000;Borges et al, 2003;Hu and Coats, 2008;Agnolin et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus

Costa-Júnior

Miller

Alves

et al. 2016

Veterinary Parasitology

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Plant-derived natural products can serve as an alternative to synthetic compounds for control of ticks of veterinary and medical importance. Lippia gracilis is an aromatic plant that produces essential oil with high content of carvacrol and thymol monoterpenes. These monoterpenes have high acaricidal activity against Rhipicephalus (Boophilus) microplus. However, there are no studies that show efficacy differences of essential oils between susceptible and organophosphate resistant strains of R. (B.) microplus. The aim of the present study was to compare acaricidal effects of essential oils extracted from two different genotypes of L. gracilis and the main monoterpenes on larvae of both susceptible and organophosphate resistant R. (B.) microplus larvae. The efficacy of the essential oil of two genotypes of L. gracilis (106 and 201) and their monoterpenes carvacrol and thymol was measured using the larval immersion test on coumaphos-resistant and susceptible strains of R. (B.) microplus. Lethal concentrations were calculated using GraphPad Prism 6.0. Chemical analysis was performed by GC-MS and FID. Thymol and carvacrol were observed to be major constituents in 106 and 201L. gracilis genotype essential oils, respectively. Essential oils of both genotypes were more effective against organophosphate-resistant tick strain than susceptible tick strain. Carvacrol was 3.2 times more toxic to organophosphate resistant strain than to susceptible strain. Thymol was equally toxic to resistant and susceptible tick strains. The significantly higher efficacy monoterpene carvacrol against resistant ticks may lead to development of new natural product acaricide formulations for use to control organophosphate resistant R. (B.) microplus populations.

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“…Insecticide activity has been reported for chemotypes I and III; it was reported on Rhipicephalus microplus, RP50 0.47-5.07 mg/cm 2 (Lima et al, 2016) and CL50 8.8-27 mg/ml (Peixoto et al, 2015b;Chagas et al, 2016), on Tribolium castaneum, RP 34-96 % in concentrations of 0.00002-0.2 μL/cm 2 (Caballero-Gallardo, Olivero-Verbel, and CL50 19.7-107.8 μL/ml, and on Sitophilus zeamais, CL50 15.2-70.8 μL/ml (Peixoto et al, 2015a). Chemotype III presents dissuasion > 80 % in oviposition of Aedes aegypti at concentrations of 0.005-0.2 µg/ml (Castillo, Stashenko, & Duque, 2017), and it also has larvicidal activity at variable concentrations: Vera et al (2014) reported CI50 0.042-0.044 µg/ml and IC95 0.089-0.099 µg/ml; Muñoz, Stashenko and Ocampo (2014), CL50 0.11 µg/ ml and CL99 0.211 µg/ml; Ríos, Stashenko and Duque (2017), CL50 63.61 -72.34 µg/ ml CL95 98.91-110.84 µg/ml; and Aldana and Cruz (2017), CL50 of 84-367 µg/ml and CL95 of 118-506 µg/ml.…”

Section: Biological Activity Of L Alba Essential Oilsmentioning

confidence: 99%

Essential oils biological activity of the Lippia alba (Verbenaceae) shrub

Ortega-Cuadros

Guevara

Castillo

et al. 2020

RBT

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Introduction: Lippia alba is an aromatic species belonging to the Verbenaceae family. Its essential oils have been used in different industries, because of its biological properties. Objective: Identify the perspectives of the biotechnological applications of Lippia alba essential oils. Methodology: A scoping review was conducted on the biological activity of Lippia alba essential oils registered until October, 2018 in EBSCO, Embase, Scopus, and Lilacs databases. Results: Chemotypes I and III have been reported for different biological activities from the evaluations performed on microorganisms, fish, arthropods, small mammals, and cell lines; fundamentally associated with antibacterial, antifungal, cytotoxic, antioxidant, and sedative effects, among others. Records focused mainly on the health, fishing industry, and agrifood sectors. Conclusion: Studies on the effect of essential oil are promising, but do not reflect a continuity of the research toward prototypes or finished commercial products. Research groups must unify evaluation methodologies and include in all studies the relationship between phytochemical and biological activity for the meta-analyses to be possible. Likewise, they must join efforts through the National System for Agricultural Innovation (SNIA, for the term in Spanish) to generate finished products that impact upon society and facilitate progress in the country’s bio-economy.

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Acaricidal activity of essential oils from Lippia alba genotypes and its major components carvone, limonene, and citral against Rhipicephalus microplus

Cited by 87 publications

References 20 publications

Induction of Synthetic Polyploids and Assessment of Genomic Stability in Lippia alba

Induction of Synthetic Polyploids and Assessment of Genomic Stability in Lippia alba

Acaricidal efficacies of Lippia gracilis essential oil and its phytochemicals against organophosphate-resistant and susceptible strains of Rhipicephalus (Boophilus) microplus

Essential oils biological activity of the Lippia alba (Verbenaceae) shrub

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