Acaricidal activity of 9-oxo-10,11-dehydroageraphorone extracted from Eupatorium adenophorum in vitro

Liao, Fei; Hu, Yanchun; Tan, Hui; Wu, Lei; Wang, Yunfei; Huang, Yue; Mo, Quan; Wei, Yahui

doi:10.1016/j.exppara.2014.02.009

Cited by 32 publications

(22 citation statements)

References 30 publications

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“…At present, many aspects of E.adenophorum are being studied widely [5]. Previous study indicated that E. adenophorum has the acaricidal activity [6–8], antitumor activity [9, 10], potential anti-inflammatory and other biological activities [11]. The previous reports showed that purified extracts from E. adenophorum could cause hepatotoxicity of mice and livestock [8, 12–15], especially the 9-oxo-10,11-dehydro-agerophorone which is the main poisonous components of E. adenophorum [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

Luo

et al. 2016

Oncotarget

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E. adenophorum has reported to cause hepatotoxicity. But, the precise effects of E. adenophorum on hepatocytes is unclear. Saanen goats were fed on E. adenophorum to detect the cytotoxicity effects of E. adenophorum on hepatocytes. Our study has shown that the typical apoptotic features, the increasing apoptotic hepatocytes and activated caspase-9, −3 and the subsequent cleavage of PARP indicated the potent pro-apoptotic effects of E. adenophorum. Moreover, the translocation of Bax and Cyt c between mitochondria and cytosol triggering the forming of apoptosome proved that the mitochondria-mediated apoptosis was triggered by E. adenophorum. Furthermore, E. adenophorum increased the MDC-positive autophagic vacuoles and the subcellular localization of punctate LC3, the ratio of LC3-II/LC3-I and the protein levels of Beclin 1, but decreased that of P62, indicating the potent pro-autophagic effects of E. adenophorum. In addition, E. adenophorum significantly inhibited the protein leves of p-PI3K, p-Akt and p-mTORC1, but increased PTEN and p-AMPK. Also, the p-mTORC2 and p-Akt Ser473 were inhibited, indicating that the supression of mTORC2/Akt pathway could induce the autophagy of hepatocytes. The autophagy-realted results indicated that the inhibition of PI3K/Akt/mTORC1- and mTORC2/Akt-mediated pathways contributed to the pro-autophagic activity of E. adenophorum. These findings provide new insights to understand the mechanisms involved in E. adenophorum-caused hepatotoxicity of Saanen goat.

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Section: Introductionmentioning

confidence: 99%

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

Luo

et al. 2016

Oncotarget

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“…Our laboratory has already extracted Euptox A from E. adenophorum Spreng and declared a national invention patent. We proved that Euptox A had highly acaricidal activity against S. scabiei and P. cuniculi in vitro and in vivo [39,40] and Euptox A presented significanty antitumor activity against the human lung cancer A549, HeLa and Hep-2 cell lines in vitro in a dose-dependent manner [41,42]. Other studies have also found that E. adenophorum Spreng contains a great amount of chlorogenic acid known as "Botanic Gold" and the extraction rate is 1%.…”

Section: Medical Resourcesmentioning

confidence: 60%

The Influence on Livestock Industry and Development Prospect of Eupatorium adenophorum Spreng

Hu¹

2015

J Microb Biochem Technol

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Eupatorium adenophorum Spreng has seriously threatened the sustainable development and the grassland ecosystem of the world livestock industry. This review has elaborated the geographic distribution, chemical constituent, damage to the grassland and livestock industry and ecological influence of Eupatorium adenophorum Spreng. The prevention and control, development and application prospect as feed and medical resources has also been stated.

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“…For example, the compounds in essential oils from this plant were found to be active on antibacterial, antioxidant (Pandey et al, 2014), and antiviral activity against tobacco mosaic virus (Jin et al, 2014). Nong et al (2012Nong et al ( , 2013Nong et al ( , 2014aNong et al ( , 2014b and Liao et al (2014) reported the acaricidal activity of this extract and the active sesquiterpenes. In our previous work, four new cadinane sesquiterpenes, including one compound with in vitro cytotoxicity against the HCT-8, Bel-7402, and A2780 cancer cell lines, had been isolated from the weed (He et al, 2008).…”

Section: Introductionmentioning

confidence: 97%

Two new highly-oxygenated flavonoid glycosides from Eupatorium adenophorum Spreng

Wang

Yang

Lee

et al. 2016

Phytochemistry Letters

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Acaricidal activity of 9-oxo-10,11-dehydroageraphorone extracted from Eupatorium adenophorum in vitro

Cited by 32 publications

References 30 publications

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat

The Influence on Livestock Industry and Development Prospect of Eupatorium adenophorum Spreng

Two new highly-oxygenated flavonoid glycosides from Eupatorium adenophorum Spreng

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