Acanthosis Nigricans in Areas of Resolving Psoriatic Plaques after Adalimumab Therapy

Abstract

Confined hyperpigmentation over areas of resolving psoriatic plaques have been described as lentiginosis, postinflammatory hyperpigmentation, nevus spillus and spleckled pigmentation. We present a case of a 46 year-old patient who developed acanthosis nigricans (AN) and lentiginosis after resolution of psoriasis when treated with adalimumab. The concomitance of the appearance of AN and the use of adalimumab, may reveal that the drug is involved in the development and persistence of the disorder.