Acanthosis nigricans, hypothyroidism, and insulin resistance

Matsuoka, Lois Y.; Wortsman, Jacobo; Gavin, James R.; Kupchella, Charles E.; J, Dietrich

doi:10.1016/0002-9343(86)90182-8

Cited by 18 publications

(13 citation statements)

References 17 publications

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“…Although, there are several studies suggesting a relationship between autoimmune diseases including Hashimoto's thyroiditis and PCOS, to our knowledge, this is the first report of PCOS and Graves' disease occurring simultaneously (6)(7)(8)(9)(10). Here, we report a case of PCOS combined with Graves' disease showing a lean body figure and normal insulin sensitivity.…”

Section: Introductionmentioning

confidence: 72%

“…The temporarily elevated SHBG and increased estradiol, testosterone and androstenedione cause such menstrual abnormalities (21)(22)(23)(24). Considering the not infrequent occurrence of Hashimoto's thyroiditis in patients with PCOS as shown in previous clinical studies (6)(7)(8)18), the very rare combination of PCOS and Graves' disease which often develop independently among young women must be interesting. The study of Janssen et al reported that the incidence of chronic autoimmune thyroiditis was 23.9% (47/175) in patients with PCOS, and they also described two subjects with Graves' disease in PCOS groups (18).…”

Section: Discussionmentioning

confidence: 98%

“…Hashimoto's thyroiditis, a prevalent autoimmune disease, has been suggested to be generally associated with PCOS (6)(7)(8). According to a recent study by Janssen et al (18) comparing 175 PCOS patients and 168 normal women, anti-thyroid antibodies were detected at a high rate in the PCOS group compared to the control group (27% versus 8.3%).…”

Section: Discussionmentioning

confidence: 99%

“…Estradiol (E2) was 45.94 pg/mL (<20-145), progesterone was 0.58 ng/mL (<1.0), prolactin was 16.24 ng/mL (0-20), and 17α-OHprogesterone was 1.11 ng/mL (0.2-1) at the 3rd day of the follicular phase. The LH/FSH ratio was 3.1 (LH 22.02 mIU/ mL (2-15), and FSH was 7.04 mIU/mL (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Progesterone withdrawal test was positive, and the polycystic ovary was confirmed by uterine ultrasonography (Fig.…”

Section: Introductionmentioning

confidence: 97%

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A 27-Year-Old Woman Diagnosed as Polycystic Ovary Syndrome Associated with Graves' Disease

et al. 2011

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Polycystic ovary syndrome (PCOS) and Graves' disease are the common causes of menstrual irregularity leading to infertility in women of child-bearing age. A 21-year-old female patient visited us with complaints of oligomenorrhea and hand tremor. She was diagnosed as having PCOS and hyperthyroid Graves' disease, simultaneously. She had low body weight (BMI: 16.4 kg/m 2 ), mild hirsutism, and thyrotoxicosis. The patient was treated with anti-thyroid drug and beta-blocker for about two years, and then recovered to normal thyroid function. Although some studies have suggested a connection between PCOS and autoimmune thyroiditis, no study indicated that PCOS is associated with Graves' disease until now. Here, we describe the first case report of a lean woman with normal insulin sensitivity presenting PCOS and Graves' disease simultaneously.

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Section: Introductionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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A 27-Year-Old Woman Diagnosed as Polycystic Ovary Syndrome Associated with Graves' Disease

et al. 2011

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“…The syndrome has been described in patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome as well as less clearly defined autoimmune disorders (12,21,(25)(26)(27). Acanthosis nigricans (a marker of insulin resistance), amenorrhea in women, and hyperandrogenism are usually present (4,12,(28)(29)(30).…”

mentioning

confidence: 99%

Treatment of systemic lupus erythematosus–associated type B insulin resistance syndrome with cyclophosphamide and mycophenolate mofetil

Gehi¹,

Webb²,

Nolte³

et al. 2003

Arthritis & Rheumatism

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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of immunologic self-tolerance and the subsequent development of autoantibodies. These antibodies are thought to be important in relation to the clinical manifestations of the disease. One example is the development of multiple cytopenias secondary to cytolytic or cytotoxic antibodies directed toward red blood cells, platelets, and white blood cells. Other antibodies may mediate abnormal cellular mechanisms such as those seen with neuropsychiatric manifestations of SLE. We report the occurrence of autoantibodies directed toward insulin receptors and the subsequent development of type B insulin resistance syndrome in a woman with SLE. This syndrome was treated successfully with cyclophosphamide and mycophenolate mofetil.

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A catalogue of multiple congenital anomaly syndromes

Winter

Baraitser

1991

Multiple Congenital Anomalies

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Acanthosis nigricans, hypothyroidism, and insulin resistance

Cited by 18 publications

References 17 publications

A 27-Year-Old Woman Diagnosed as Polycystic Ovary Syndrome Associated with Graves' Disease

A 27-Year-Old Woman Diagnosed as Polycystic Ovary Syndrome Associated with Graves' Disease

Treatment of systemic lupus erythematosus–associated type B insulin resistance syndrome with cyclophosphamide and mycophenolate mofetil

A catalogue of multiple congenital anomaly syndromes

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