Acanthosis nigricans associated with mycosis fungoides

A case of acanthosis nigricans–like mycosis fungoides

“…Interestingly, AN has been described as a paraneoplastic phenomenon in cases of MF, in both the classical 1 , 3 , 4 and vegetating/papillomatous types. 2 , 7 The concomitant presentation of AN (benign or paraneoplastic) and AN-like MF makes diagnosis and distinction between the 2 entities difficult.…”

“…However, rare cases of AN secondary to underlying cutaneous T-cell lymphoma have been described. 1 , 2 , 3 , 4 Complicating matters, an exceedingly rare, vegetating/papillomatous variant of mycosis fungoides (MF), referred to as “AN-like MF” has been reported. 2 , 5 , 6 , 7 MF is the most common form of cutaneous T-cell lymphoma and the most prevalent form of primary cutaneous lymphoma overall.…”

T follicular helper phenotype mycosis fungoides associated with acanthosis nigricans

“…Only four cases of paraneoplastic AN associated with MF have been reported, 6,7,12,14 and only six cases of AN-like or papillomatous/vegetating MF. 6,7,[15][16][17][18] with histopathological evidence of the typical features of MF and AN together (Table 1). However, given the rarity of these manifestations, it is still unclear whether the combina- It is known that AN in patients with solid tumors may be as a resulf of a proliferative stimulus induced by fibroblast growth factor receptors and tyrosine kinase receptors such as epidermal growth factor receptors, but little is known about its development in patients with hematological tumors or MF.…”

A case of acanthosis nigricans coexisting with mycosis fungoides

“…Of the five previous case reports describing a true association of ANM and mycosis fungoides, the age ranged from 36 to 58 years old and was seen predominantly in males (four of five cases) [6][7][8][9][10]. Only a single case explicitly identified a non-diabetic patient.…”