A case of acanthosis nigricans coexisting with mycosis fungoides

Cheng, Esther; Roy, David B; Magro, Cynthia M.

doi:10.5070/d3217028120

Cited by 4 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 In obese patients and those with diabetes mellitus or metabolic syndrome, hyperinsulinemia and IGF-1 activate receptors on keratinocytes and fibroblasts, thus stimulating epithelial growth. In four of the published cases, AN was associated with diabetes mellitus 14,17,18 and gestational diabetes. 7 The epidemiological and clinical characteristics of our patient adequately match the presentations described in the literature, but the histopathological features of the case are more difficult to interpret because of the simultaneous presence of classic MF and AN lesions with only a few atypical lymphocytes determining the finding of the same clone in different sites.…”

Section: Discussionmentioning

confidence: 97%

“…In obese patients and those with diabetes mellitus or metabolic syndrome, hyperinsulinemia and IGF‐1 activate receptors on keratinocytes and fibroblasts, thus stimulating epithelial growth. In four of the published cases, AN was associated with diabetes mellitus 14,17,18 and gestational diabetes 7 …”

Section: Discussionmentioning

confidence: 99%

“…The literature separates cases of MF associated with AN from those of MF with the clinical or histopathological features of AN (AN‐like MF). Only four cases of paraneoplastic AN associated with MF have been reported, 6,7,12,14 and only six cases of AN‐like or papillomatous/vegetating MF 6,7,15–18 . with histopathological evidence of the typical features of MF and AN together (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…Only four cases of paraneoplastic AN associated with MF have been reported, 6,7,12,14 and only six cases of AN-like or papillomatous/vegetating MF. 6,7,[15][16][17][18] with histopathological evidence of the typical features of MF and AN together (Table 1). However, given the rarity of these manifestations, it is still unclear whether the combina- It is known that AN in patients with solid tumors may be as a resulf of a proliferative stimulus induced by fibroblast growth factor receptors and tyrosine kinase receptors such as epidermal growth factor receptors, but little is known about its development in patients with hematological tumors or MF.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

T follicular helper phenotype mycosis fungoides associated with acanthosis nigricans

et al. 2023

View full text Add to dashboard Cite

The association between acanthosis nigricans (AN) and mycosis fungoides (MF) has rarely been described, but it is known that MF may appear as AN‐like vegetating and papillomatous plaques in skin folds, or may be associated with paraneoplastic AN. There have also been recent descriptions of a form of “intertriginous MF” that is characterized by skin fold involvement and the expression of T follicular helper (TFH) markers, and that often has an aggressive course. We describe the case of a 48‐year‐old man affected by MF associated with AN, whose lesions were characterized by a TFH immunophenotype and the expression of the GATA‐3 nuclear master regulator that may be related to a TFH‐2 subpopulation or possible disease progression.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

T follicular helper phenotype mycosis fungoides associated with acanthosis nigricans

et al. 2023

View full text Add to dashboard Cite

show abstract

A case of acanthosis nigricans–like mycosis fungoides

Kim¹,

Truong²,

Paik³

et al. 2021

JAAD Case Reports

View full text Add to dashboard Cite

Acanthosis Nigricans: An Updated Review

Leung

Lam

Barankin³

et al. 2023

CPR

View full text Add to dashboard Cite

Background: Early recognition of acanthosis nigricans is important because acanthosis nigricans can be a cutaneous manifestation of a variety of systemic disorders and, rarely, as a sign of internal malignancy. Objective: This purpose of this article is to familiarize pediatricians with the clinical manifestations, evaluation, diagnosis, and management of acanthosis nigricans. Methods: A search was conducted in November 2021 in PubMed Clinical Queries using the key term "acanthosis nigricans". The search strategy included all clinical trials, observational studies, and reviews published within the past 10 years. Only papers published in the English literature were included in this review. The information retrieved from the above search was used in the compilation of the present article. Results: Acanthosis nigricans is characterized by symmetric, hyperpigmented, velvety plaques with ill-defined borders, typically involving intertriginous areas. Obesity is the most common cause of acanthosis nigricans which is increasing observed in obese children and adolescents and can serve as a cutaneous marker of insulin resistance. Early recognition of acanthosis nigricans is important because acanthosis nigricans can also be a cutaneous manifestation of a variety of systemic disorders and, rarely, as a sign of internal malignancy. The diagnosis is mainly clinical, based on the characteristic appearance (symmetrically distributed, hyperpigmented, velvety, papillomatous, hyperkeratotic plaques with ill-defined borders) and the typical sites (intertriginous areas, flexural area, and skin folds) of the lesions. Although acanthosis nigricans is treatable, complete cure is difficult to achieve. The underlying cause should be treated, if possible, to resolve and prevent recurrence of acanthosis nigricans. This may consist of weight reduction, discontinuation of causative drugs, treatment of underlying endocrinopathy, or treatment of an underlying malignancy. For patients with isolated acanthosis nigricans and for those whose underlying cause is not amenable to treatment, treatment of the lesion may be considered for cosmetic reasons. Topical retinoids, vitamin D analogs, chemical peels, and other keratolytics are often used for the treatment of localized lesions. Seldom, systemic therapy such as oral retinoids may be considered for extensive or generalized acanthosis nigricans and acanthosis nigricans unresponsive to topical therapy. Other uncommon treatment modalities include dermabrasion, laser therapy, and surgical removal. Conclusion: Although acanthosis nigricans is treatable, complete cure is difficult to achieve. The underlying cause should be treated, if possible, to resolve and prevent recurrence of acanthosis nigricans. The diagnosis is mainly clinical, based on the characteristic appearance (symmetrically distributed, hyperpigmented, velvety, papillomatous, hyperkeratotic plaques with ill-defined borders) and the typical sites (intertriginous areas, flexural area, and skin folds) of the lesions. The diagnosis might be difficult for lesions which have atypical morphology or are in an unusual location Due to the association between acanthosis nigricans and underlying pathologies, clinicians should be knowledgeable about the clinical manifestations, evaluation, diagnosis, and management of acanthosis nigricans.

show abstract

A case of acanthosis nigricans coexisting with mycosis fungoides

Cited by 4 publications

References 9 publications

T follicular helper phenotype mycosis fungoides associated with acanthosis nigricans

T follicular helper phenotype mycosis fungoides associated with acanthosis nigricans

A case of acanthosis nigricans–like mycosis fungoides

Acanthosis Nigricans: An Updated Review

Contact Info

Product

Resources

About