Acanthomatous ameloblastoma in a female Spitz dog with rare atypical histomorphology: A case study

Abstract

A 6 year old female Spitz dog was admitted to Teaching Veterinary Hospital at Chittagong Veterinary and Animal Sciences University with the history of inappetance and asymmetric lower jaw. Oral inspection revealed a pair of pale enlarged lobulated mass around the third molar tooth of the left mandible. The dog was clinically diagnosed with epulis and successfully cured by surgical excision. Histopathological section of the excised masses revealed characteristic features of acanthomatous ameloblastoma with some atypical lesions. Multifocal areas of ameloblastic islands were found in the dense sheet of proliferating epithelial layer protruding towards the sub epithelial connective tissue stroma. These islands were characterized with irregular epithelial stratification at the basal layer. Besides, presence of ghost cells was the unusual findings for such case. Prominent intercellular bridging and nuclear polymorphism in odontogenic cells were other decisive characters of the lesion. Based on the histomorphological appearance, the gingival tumor was designated as canine acanthomatous ameloblastoma (CAA) with atypical histomorphology.

Novel Approach of Foldscope for Diagnosis of Epithelial Tumors in Animals

“…Examination of acanthomatous papilloma revealed marked increased thickness of stratum spinosum layer as reported by Das et al, (2013).…”

A dinosaurian facial deformity and the first occurrence of ameloblastoma in the fossil record

“…The presence of this benign neoplasic modification is reported here for the first time in the dinosaurian fossil record, as well as in the fossil record overall. The occurrence of ameloblastoma is a well-known phenomenon in humans 37 and other mammals 38 , yet has only recently been identified among reptiles in the living wild black rat snake 39 . A related disorder, adenoameloblastoma, was noted in the Indian rock python 40 .…”