Acalculous cholecystitis during the course of acute Epstein–Barr virus infection

Katsogridakis, Konstadinos; Dasenaki, Maria

doi:10.1016/j.ijid.2008.06.031

Cited by 18 publications

(8 citation statements)

References 3 publications

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“…All but one, a 53-year-old woman, were children or young adults, and all were reported in the last 3 years. [7][8][9][10][11][23][24][25][26] This may be because of increased awareness of this condition in recent years. These patients shared common clinical and laboratory findings, and all were previously healthy with no known underlying medical conditions (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] Cholestatic hepatitis with mild liver dysfunction has been reported in more than 90% of patients with primary EBV infection, but severe liver dysfunction or gallbladder (GB) involvement is rare. 6 A literature review found that only a few cases of acalculous cholecystitis have been reported during the course of primary EBV infection, [7][8][9][10][11] all during the last 3 years. We report the case of a teenaged girl with acute acalculous cholecystitis (AAC) caused by EBV infection, the first in the United States, and review the relevant literature.…”

Section: Introductionmentioning

confidence: 99%

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Epstein Barr Virus—Associated Acute Acalculous Cholecystitis: A Rare Occurrence but Favorable Outcome

Arya

Saini

El‐Baba

et al. 2010

Clin Pediatr (Phila)

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epstein Barr Virus—Associated Acute Acalculous Cholecystitis: A Rare Occurrence but Favorable Outcome

Arya

Saini

El‐Baba

et al. 2010

Clin Pediatr (Phila)

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“…Approximately 5-10% of all patients with acute cholecystitis present with AAC, which is usually associated with more serious morbidity and higher mortality rates than calculous cholecystitis [2]. To date, only nine cases of AAC caused by EBV infection have been reported, although no cases have been reported in Korea [3,4,5,6,7,8,9,10,11]. We describe a case of AAC that occurred during the course of a primary EBV infection.…”

Section: Introductionmentioning

confidence: 99%

Epstein-Barr Virus Infection with Acute Acalculous Cholecystitis

Kim

Yang

Moon

et al. 2014

Pediatr Gastroenterol Hepatol Nutr

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Acute acalculous cholecystitis (AAC) is an inflammation of the gallbladder in the absence of demonstrated stones. AAC is frequently associated with severe systemic inflammation. However, the exact etiology and pathogenesis of AAC still remain unclear. Acute infection with Epstein Barr virus (EBV) in childhood is usually aymptomatic, whereas it often presents as typical infectious mononucleosis symptoms such as fever, cervical lymphadenopathy, and hepatosplenomegaly. AAC may occur during the course of acute EBV infection, which is rarely encountered in the pediatric population. AAC complicating the course of a primary EBV infection is usually associated with a favorable outcome. Most of the patients recover without any surgical treatment. Therefore, the detection of EBV in AAC would be important for prediction of better prognosis. We describe the case of a 10-year-old child who presented with AAC during the course of primary EBV infection, the first in Korea, and review the relevant literature.

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“…Only 16 other patients with EBV-associated AAC have been previously reported, with our case being one of the first in North America. [5][6][7][8][9][10][11][12][13][14][15] Fortunately, AAC complicating the course of primary EBV infection is associated with a favorable outcome. 13 The etiology of AAC is thought to be due to bile stasis, coupled with increased lithogenicity of bile.…”

Section: Discussionmentioning

confidence: 99%

Fever and Jaundice in a Previously Healthy Teenager

Say

Chaparro

Koning

et al. 2016

Clin Pediatr (Phila)

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A previously healthy 14-year-old girl was transferred to our facility from an outside hospital with a 10-day history of nausea, malaise, intermittent fever (peak 39.5°C), and fatigue. In the 72 hours prior to admission, she had developed progressive yellowing of the skin and scleral icterus. She had not traveled recently and her immunizations were up-to-date. She denied being sexually active or using illicit substances. She was a well-developed Caucasian adolescent who on initial presentation appeared fatigued and jaundiced. Vital signs on admission were the following: temperature, 38.8°C; heart rate, 96 beats per minute; respiratory rate, 18 breaths per minute; and blood pressure, 112/58 mm Hg. Her physical examination revealed scleral icterus, pharyngeal erythema with tonsillar exudates, anterior cervical lymphadenopathy, and right-sided abdominal tenderness. The liver edge was palpable at 1 cm below the right costal margin.Laboratory evaluation from the outside hospital revealed transaminase elevation and elevated serum bilirubin levels (Table 1). Complete blood count did not demonstrate evidence of anemia, thrombocytopenia, leukocytosis, or bandemia. Lipase level was normal at 32 U/L (23-300 U/L), though a C-reactive protein was mildly elevated at 1.20 mg/dL (<0.99 mg/ dL). Acetaminophen level was negative at <10.0 µg/ mL (10-25 µg/mL). Coagulation studies were within the reference range. An initial ultrasound of the abdomen showed diffuse thickening of the gallbladder wall, measuring up to 8.5 mm in thickness, with no evidence of biliary duct dilatation or the presence of stones (Figure 1). Splenomegaly was also seen. The patient did report right upper quadrant tenderness during the ultrasound, exhibiting the positive sonographic Murphy's sign. These findings were consistent with a working diagnosis of acute acalculous cholecystitis (AAC), and empiric broad-spectrum antibiotic therapy with piperacillin-tazobactam was initiated. All oral feeds were held and aggressive intravenous hydration was initiated.

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Acalculous cholecystitis during the course of acute Epstein–Barr virus infection

Cited by 18 publications

References 3 publications

Epstein Barr Virus—Associated Acute Acalculous Cholecystitis: A Rare Occurrence but Favorable Outcome

Epstein Barr Virus—Associated Acute Acalculous Cholecystitis: A Rare Occurrence but Favorable Outcome

Epstein-Barr Virus Infection with Acute Acalculous Cholecystitis

Fever and Jaundice in a Previously Healthy Teenager

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