Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet–fed mice

Santos, Izabelle Barcellos; de, Graziele Freitas; Costa, Cristiane Aguiar da; Carvalho, Lenize Costa Reis Marins de; Medeiros, Amanda Faria de; Silva, Dafne Lopes Beserra; Romão, Matheus Henrique; Soares, Ricardo de Andrade; Ognibene, Dayane Teixeira; Moura, Roberto Soares de; Resende, Ângela Castro

doi:10.1016/j.nutres.2020.05.006

Cited by 28 publications

(14 citation statements)

References 50 publications

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“…This fruit has a tart flavor and is produced by the Euterpe oleracea palm, which can only be found in the Amazon. For millennia, Amazonian Indians have employed the açai fruit, which is regarded as a high-energy meal, as a food source and a natural remedy for a number of illnesses [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways

Impellizzeri

D’Amico

Fusco

et al. 2022

Cells

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The second-most common cause of dementia is vascular dementia (VaD). The majority of VaD patients experience cognitive impairment, which is brought on by oxidative stress and changes in autophagic function, which ultimately result in neuronal impairment and death. In this study, we examine a novel method for reversing VaD-induced changes brought on by açai berry supplementation in a VaD mouse model. The purpose of this study was to examine the impact of açai berries on the molecular mechanisms underlying VaD in a mouse model of the disease that was created by repeated ischemia–reperfusion (IR) of the whole bilateral carotid artery. Here, we found that açai berry was able to reduce VaD-induced behavioral alteration, as well as hippocampal death, in CA1 and CA3 regions. These effects are probably due to the modulation of nuclear factor erythroid 2-related factor 2 (Nrf-2) and Beclin-1, suggesting a possible crosstalk between these molecular pathways. In conclusion, the protective effects of açai berry could be a good supplementation in the future for the management of vascular dementia.

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Section: Introductionmentioning

confidence: 99%

Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways

Impellizzeri

D’Amico

Fusco

et al. 2022

Cells

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“…The açai berries were pulped, and only the seeds were used to produce the GA-conjugated extract. The use of açai seed is justified because the industrialization of açai pulp generates a large amount of residues that are considered environmental pollutants and which may still have biological properties of interest to human health [ 21 ]. The extract was produced only with hot water at a low pH via the addition of citric acid.…”

Section: Methodsmentioning

confidence: 99%

Amazonian Guarana- and Açai-Conjugated Extracts Improve Scratched Fibroblast Healing and Eisenia fetida Surgical Tail Amputation by Modulating Oxidative Metabolism

Felin

Maia-Ribeiro

Felin

et al. 2022

Oxidative Medicine and Cellular Longevity

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Background. Previous studies have suggested that guarana (Paullinia cupana) and açai (Euterpe oleracea) have antioxidant, anti-inflammatory, and proliferative properties, indicating their potential therapeutic action in wound healing. We produced a conjugated guarana-açai (GA) extract and tested its healing action on earthworms (Eisenia fetida) subjected to tail amputation by surgical incision. Methods. Extract from roasted guarana seeds and fresh açai seed berries was produced. The antioxidant and genoprotective capacity of GA extract was tested. The concentration with the most remarkable healing potential was used in subsequent tests. The last three posterior segments of the clitellate earthworm tail reared under standardized conditions were surgically amputated. Next, topical PBS or GA extract was applied to the surgical wound. The rate of cell migration and tissue regeneration at the local wound site was histologically evaluated after the procedure. Expression of the SOX4 gene that acts in epithelial-to-mesenchymal transition was determined by RT-qPCR. Results. Sixteen bioactive molecules, including some previously described substances, were identified. All tested concentrations exhibited antioxidant and genoprotective effects. The GA extract accelerated the healing processes as observed through macroscopic and histological analyses and increased expression of SOX4. Conclusion. The GA extract has a potential role in the healing of surgically induced wounds.

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“…Where another study demonstrates that ACE2 expression in adipose tissue is higher than that in lung tissue, a major target tissue affected by SARS-CoV-2 infection. (Santos et al, 2020). Complex interactions occur between adipose tissue and the immune system.…”

Section: Glucose Level In Male and Female Covid-19 Patients And Contr...mentioning

confidence: 99%

Comparative study of Resistin and Glucose levels in COVID-19 patients

Kenoosh¹,

Awad

2022

ijhs

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Since the end of 2019, coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has spread worldwide, it causes risks to public health. Adipokines perform a hormonal function and the most important adipokines that have received research interest are resistin, which is an important link between insulin resistance, and diabetes. This study aimed to estimate the level of Resistin and level of glucose and their relationship to diabetes in Covid-19 patients. The study was conducted on 65 patients with covid-19 and 23 healthy individuals in a control group, Resistin was assessed by the ELISA technique, it was resistin levels in male and female Covid-19 patients high(737.5714±103.44982, 638.5000±85.20096 respectively pg\ml) when compared to healthy males and females (363.7692±26.83405, 394.0000± 30.59412 respectively pg\ml).An elevated glucose level was observed in male and female patients (122.2000±9.703, 145.6667±11.55 mg/dl respectively)when compared to healthy males and females (90.8462±6.346, 102.3000±7.701 mg /dl respectively), This research found a high level of Resistin in Covid-19 patients.Therefore, it can be used as an important indicator to signify the complications of COVID-19 disease as well as for diagnosis, this hormone may have a relationship in causing new diabetes after infection Covid-19.

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Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet–fed mice

Cited by 28 publications

References 50 publications

Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways

Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways

Amazonian Guarana- and Açai-Conjugated Extracts Improve Scratched Fibroblast Healing and Eisenia fetida Surgical Tail Amputation by Modulating Oxidative Metabolism

Comparative study of Resistin and Glucose levels in COVID-19 patients

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