A novel coronavirus, known as Severe Acute Respiratory Syndrome- Coronavirus 2, has just emerged as an epidemic danger to worldwide public health, Diabetes increases the severity and mortality rate of COVID-19. Adipokines perform a hormonal function including apelin is the newest finding among adipokines and has drawn much Research interest about its functions. This study aimed to estimate the level of apelin hormone in Covid-19 patients and the relationship of this hormone to the level of glucose. The study included 65 patients and 23 healthy as a control group. Apelin hormone was determined by ELISA technique, the level of the hormone Apelin elevated in male and female Covid-19 patients (3752.8571±81.60529, and 3786.3333±96.92097 respectively pg\ml) when compared to the control group for males and females (112.8462±7.79287, and 151.3000±22.20913 respectively pg\ml), High level of glucose in male and female patients (122.2000±9.703, 145.6667±11.55 mg/dl respectively) when compared to healthy males and females (90.8462±6.346, 102.3000±7.701 mg /dl respectively). This study shows a very high increase of apelin hormone in Covid-19 patients compared to healthy. it can be used as a predictive biomarker for the risk of deterioration and disease progression. also, It has an important role in managing COVID-19 patients.
Since the end of 2019, coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 has spread worldwide, it causes risks to public health. Adipokines perform a hormonal function and the most important adipokines that have received research interest are resistin, which is an important link between insulin resistance, and diabetes. This study aimed to estimate the level of Resistin and level of glucose and their relationship to diabetes in Covid-19 patients. The study was conducted on 65 patients with covid-19 and 23 healthy individuals in a control group, Resistin was assessed by the ELISA technique, it was resistin levels in male and female Covid-19 patients high(737.5714±103.44982, 638.5000±85.20096 respectively pg\ml) when compared to healthy males and females (363.7692±26.83405, 394.0000± 30.59412 respectively pg\ml).An elevated glucose level was observed in male and female patients (122.2000±9.703, 145.6667±11.55 mg/dl respectively)when compared to healthy males and females (90.8462±6.346, 102.3000±7.701 mg /dl respectively), This research found a high level of Resistin in Covid-19 patients.Therefore, it can be used as an important indicator to signify the complications of COVID-19 disease as well as for diagnosis, this hormone may have a relationship in causing new diabetes after infection Covid-19.
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