Ac36deoGlcNAz could selectively label O-GlcNAc modified proteins with minimal S-glyco-modification

Cao, Wu; Zheng, Lu; Dou, Biao; Zeng, Xueke; Cao, Mengji; Wang, Jiajia; Li, Xia

doi:10.1016/j.cclet.2022.06.021

Cited by 3 publications

(3 citation statements)

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“…The proteomics platforms that have evolved over the past 20 years-gel, label, gel free/label free, targeted-are used to describe protein profiles, posttranslational changes, and interactions [45]. Isolation, separation, visualization, and precise protein identification are among the many aspects of any proteomic technique that ultimately determine its effectiveness [44]. Despite recent developments, more attention needs to be paid to protein extraction procedures, especially for proteins that are hydrophobic and large molecular mass proteins [39].…”

Section: Nanoparticle-plant Interaction: Transcriptomic and Proteomic...mentioning

confidence: 99%

“…The suppression of genes for root development and pathogen response is a common consequence of abiotic stress [43]. There are reviews of further works that support these findings [44,45]. In a similar vein, additional research has shown that in Arabidopsis thaliana seedlings, gene expression for the peroxide-scavenging enzyme was influenced by CNTs [46].…”

Section: Introductionmentioning

confidence: 95%

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Plant–Nanoparticle Interactions: Transcriptomic and Proteomic Insights

Munir,

Gulzar,

Abideen

et al. 2023

Agronomy

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In recent years, the relationship between plants and nanoparticles (NPs) has been the subject of extensive research interest. Hence, an ever-increasing number of perspectives connected with both the positive and adverse consequences of NPs application in plants are highlighted in this review. On the other hand, nanoparticles and their interactive effects on plants have raised concern regarding their harmful aspects. There are complex mechanisms evolved in plants for controlling the uptake, accumulation, and mobilization of nanoparticles that need to be discussed further, especially in the context of proteomics and genetic level. To fill this gap, there is a dire need for the integration and application of multiomics in plants to identify sensitive biomarkers responding to engineered NPs and to provide mechanistic insights in order to design safer and enhanced nano-enabled products for agriculture. For this purpose, transcriptomic technologies have essentially contributed to understanding of the molecular systems in plants against nanoparticle stress by laying out an association between gene expression and cell response. In light of this background, the current article attempts to summarize a variety of recent transcriptomic and proteomic contributions that have been made to establishing the genetic basis of nanoparticle uptake and the mechanism of stress response. The present article also looks at recent proteomic and transcriptomic studies to learn more about the intricate regulatory network that connects plant and nanoparticle stress responses.

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Section: Nanoparticle-plant Interaction: Transcriptomic and Proteomic...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Plant–Nanoparticle Interactions: Transcriptomic and Proteomic Insights

Munir,

Gulzar,

Abideen

et al. 2023

Agronomy

View full text Add to dashboard Cite

show abstract

“…16 The success of this partially protected method reduced, to some extent, the penetration of metabolic glycan probes into the cell membrane, and thus, a next generation of improved MCRs for high labeling of O -GlcNAc proteins is urgently needed. Meanwhile, our group also disclosed several probes for specific labeling of intracellular O -GlcNAcylated proteins without this leading to S -glyco modification, including Ac 3 6deoGlcNAz 17 and Ac 3 4FGlcNAz. 18 Our findings indicated that subtle modifications of the structure of GlcNAc will, surprisingly, avoid this S -linked side reaction.…”

Section: Introductionmentioning

confidence: 99%