AC electroosmosis micromixing on a lab-on-a-foil electric microfluidic device

Wu, Mengren; Gao, Yuan; Ghaznavi, Amirreza; Zhao, Weiqi; Xu, Jie

doi:10.1016/j.snb.2022.131611

Cited by 18 publications

(14 citation statements)

References 32 publications

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“…This scalable microvortex generation device offers a prototype for studying flow patterning and suggests the possibility of being used as a micromixing chip. [10,[43][44][45][46] In addition, as these pumping devices are powered by AC power without any external moving part, they are suitable for miniaturization and integration for lab-on-chip applications. [4,5,47] Here, we further demonstrated an active microfluidic device with independently controlled flow channels, which is highly desired in microanalysis chip.…”

Section: Active Microfluidic Devices Based On Asymmetrically Coated M...mentioning

confidence: 99%

“…This scalable microvortex generation device offers a prototype for studying flow patterning and suggests the possibility of being used as a micromixing chip. [ 10,43–46 ]…”

Section: Active Microfluidic Devices Based On Asymmetrically Coated M...mentioning

confidence: 99%

“…These devices utilize the principles of electroosmosis to drive fluid flow in microscale systems, providing precise and controlled fluid handling in small volumes without the need for external actuators. [9,10] Electrophoretic micropumps can be miniaturized for integration into portable flow control devices, making them an important tool for advancing microfluidics in a broad range of applications. [11][12][13][14] On the other hand, as the size of microfluidic device shrinks, the pressure demand to maintain the appreciable flow rate soars.…”

Section: Introductionmentioning

confidence: 99%

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Simple Electroosmotic Pump and Active Microfluidics with Asymmetrically Coated Microelectrodes

et al. 2023

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Electroosmotic pumps can deliver liquid without moving parts, making them suitable for microfluidic and lab‐on‐chip systems. Previously, alternating current electroosmotic pumps were constructed using pairs of coplanar asymmetrical interdigitated microelectrodes on the same substrate. In this work, a simpler micropumping system is developed, separating the electrodes on two substrates and breaking the symmetry by half‐depositing electrodes with 3D microstructures. Numerical simulation models of the pumping system and experimental velocity profiles are used to explain the fluid motion mechanism and structure‐dependent pumping performance. In addition to its efficiency and simplicity, this new pumping system also allows for the creation of a microvortex device and an active microfluidics device. This scalable micropumping system provides a way to pump liquids at microscopic or macroscopical scale in complex microfluidics systems.

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Section: Active Microfluidic Devices Based On Asymmetrically Coated M...mentioning

confidence: 99%

“…This scalable microvortex generation device offers a prototype for studying flow patterning and suggests the possibility of being used as a micromixing chip. [ 10,43–46 ]…”

Section: Active Microfluidic Devices Based On Asymmetrically Coated M...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simple Electroosmotic Pump and Active Microfluidics with Asymmetrically Coated Microelectrodes

et al. 2023

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“…As a droplet-based micromixer platform, AC electrostatic excited micromixer is a unique microfluidic system used to induce vibration and deformation in a liquid marble, but it could have negative consequences of high electric field strengths of 385 kV.m −1 in biological applications [ 86 ]. On the other hand, the lab-on-a-foil concept is the AC electroosmosis micromixer that emerged as an innovative approach [ 87 ]. In the study, tooth-shaped planar electrodes were fabricated inside the PDMS microchannel, and electroosmotic flow (EOF) was investigated depending on the flow rate and applied signal frequency [ 87 ].…”

Section: Microfluidicsmentioning

confidence: 99%

“…On the other hand, the lab-on-a-foil concept is the AC electroosmosis micromixer that emerged as an innovative approach [ 87 ]. In the study, tooth-shaped planar electrodes were fabricated inside the PDMS microchannel, and electroosmotic flow (EOF) was investigated depending on the flow rate and applied signal frequency [ 87 ]. According to the results, the optimum values for mixing performance were 1 Hz for signal frequency and 15, 20, 25, and 30 μL/min for flow rates [ 87 ].…”

Section: Microfluidicsmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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Strategies to Realize AC Electrokinetic Enhanced Mass‐Transfer in Silicon Based Photonic Biosensors.

Henriksson,

Neubauer,

Birkholz

2024

Adv Materials Technologies

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Silicon‐on‐insulator (SOI) based photonic sensors, particularly those utilizing Photonic Integrated Circuit (PIC) technology, have emerged as promising candidates for miniaturized bioanalytical devices. These sensors offer real‐time responses, occupy minimal space, possess high sensitivity, and facilitate label‐free detection. However, like many biosensors, they face challenges when detecting analytes at exceedingly low concentrations due to limitations in mass transport. An intriguing method to enhance mass transfer in microfluidic biosensors is AC electrokinetics. Proof‐of‐concept experiments have demonstrated significant enhancements in limit of detection (LOD) and response times. AC electrokinetics, compatible with silicon photonic sensors, offers techniques such as electroosmosis, electrothermal effects, and dielectrophoresis to modify fluid flow and manipulate particle trajections. This article delves into various approaches for integrating AC electrokinetics into silicon photonic biosensors, shedding light on both its advantages and limitations.

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AC electroosmosis micromixing on a lab-on-a-foil electric microfluidic device

Cited by 18 publications

References 32 publications

Simple Electroosmotic Pump and Active Microfluidics with Asymmetrically Coated Microelectrodes

Simple Electroosmotic Pump and Active Microfluidics with Asymmetrically Coated Microelectrodes

Biomedical Applications of Microfluidic Devices: A Review

Strategies to Realize AC Electrokinetic Enhanced Mass‐Transfer in Silicon Based Photonic Biosensors.

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