Abyssomicins G and H and atrop-Abyssomicin C from the Marine Verrucosispora Strain AB-18-032†

Keller, Simone; Nicholson, Graeme; Drahl, Carmen; Sorensen, Erik J.; Fiedler, Hans‐Peter; Süssmuth, Roderich D.

doi:10.1038/ja.2007.54

Cited by 103 publications

(112 citation statements)

References 14 publications

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“…Interestingly, only abyssomicin C and its atrop stereoisomer show antibiotic activity against Gram-positive bacteria, including MDR S. aureus. 26 An additional example of a new chemical class discovered by screening new taxa is represented by thuggacins (Figure 1), which are thiazole-containing macrolides produced by the myxobacteria Sorangium cellulosum and Chondromyces crocatus. 27 These compounds show activity against Mycobacterium tuberculosis and their target appears to be the electron transport chain.…”

Section: Approaches Leading To New Antibiotic Classesmentioning

confidence: 99%

Antibiotic discovery in the twenty-first century: current trends and future perspectives

Donadio¹,

Maffioli²,

Monciardini³

et al. 2010

J Antibiot

223

126

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New antibiotics are necessary to treat microbial pathogens that are becoming increasingly resistant to available treatment. Despite the medical need, the number of newly approved drugs continues to decline. We offer an overview of the pipeline for new antibiotics at different stages, from compounds in clinical development to newly discovered chemical classes. Consistent with historical data, the majority of antibiotics under clinical development are natural products or derivatives thereof. However, many of them also represent improved variants of marketed compounds, with the consequent risk of being only partially effective against the prevailing resistance mechanisms. In the discovery arena, instead, compounds with promising activities have been obtained from microbial sources and from chemical modification of antibiotic classes other than those in clinical use. Furthermore, new natural product scaffolds have also been discovered by ingenious screening programs. After providing selected examples, we offer our view on the future of antibiotic discovery.

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Section: Approaches Leading To New Antibiotic Classesmentioning

confidence: 99%

Antibiotic discovery in the twenty-first century: current trends and future perspectives

Donadio¹,

Maffioli²,

Monciardini³

et al. 2010

J Antibiot

223

126

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“…The discovery of novel natural products in marine microorganisms has increased linearly over the past two decades while those found in terrestrial microorganisms have remained almost unchanged over the same period [3]. Recently, we reported on the fermentation, isolation and structure elucidation of abyssomicins BϳD, novel polycyclic polyketide antibiotics from the marine actinomycete "Verrucosispora maris" AB-18-032 which was isolated from sediment collected from the Sea of Japan [1,4,5]. The careful evaluation of HPLC chromatograms from extracts of this strain revealed significant amounts of another compound (1) not assignable to any other known compound in our HPLC-UV-Vis database [6].…”

Section: Introductionmentioning

confidence: 99%

Proximicin A, B and C, Novel Aminofuran Antibiotic and Anticancer Compounds Isolated from Marine Strains of the Actinomycete Verrucosispora†

et al. 2008

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A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown g -amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

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“…The genus Verrucosispora, which was established by Rheims et al (1998) as a member of the family Micromonosporaceae, has drawn much attention in recent years because it has proved to be a source of potential antitumour compounds such as abyssomicin, gifhornenolones and proximicins (Bister et al, 2004;Keller et al, 2007;Riedlinger et al, 2004;Schneider et al, 2008;Shirai et al, 2010). At the time of writing, this genus comprised three species with validly published names, Verrucosispora gifhornensis, Verrucosispora lutea and Verrucosispora sediminis, with type strains isolated from peat bog, mangrove sediment and deep-sea sediment, respectively (Rheims et al, 1998;Liao et al, 2009;Dai et al, 2010).…”

mentioning

confidence: 99%

Description of Verrucosispora qiuiae sp. nov., isolated from mangrove swamp sediment, and emended description of the genus Verrucosispora

Zhang

Ruan

et al. 2012

International Journal of Systematic and Evolutionary Microbiology

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A Micromonospora -like strain, RtIII47T, was isolated from a mangrove swamp in Sanya, Hainan Province, China. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that the strain had a close association with the genus Verrucosispora and shared the highest sequence similarity with Verrucosispora lutea YIM 013T (98.0 %). The strain also showed high 16S rRNA gene sequence similarities to Micromonospora olivasterospora DSM 43868T (97.9 %), Plantactinospora mayteni YIM 61359T (97.9 %), Salinispora tropica CNB-440T (97.8 %), Micromonospora peucetia DSM 43363T (97.7 %), Micromonospora auratinigra TT1-11T (97.7 %), Verrucosispora sediminis CGMCC 4.3550T (97.6 %) and Salinispora arenicola CNH-643T (97.5 %). Phylogenetic analysis based on the gyrB gene sequence supported the conclusion that strain RtIII47T should be assigned to the genus Verrucosispora . DNA–DNA relatedness between strain RtIII47T and the most closely related type strain, V. lutea YIM 013T, was less than 40 %. Chemotaxonomic results confirmed the taxonomic position of the isolate in the genus Verrucosispora , and revealed differences at the species level in polar lipids, whole-cell sugars and DNA G+C content. A combination of physiological and biochemical tests also distinguished this strain from other Verrucosispora species. Based on genotypic and phenotypic observations, strain RtIII47T ( = CGMCC 4.5826T = NBRC 106684T) is proposed as the type strain of a novel species, Verrucosispora qiuiae sp. nov. An emended description of the genus Verrucosispora is also provided.

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Abyssomicins G and H and atrop-Abyssomicin C from the Marine Verrucosispora Strain AB-18-032†

Cited by 103 publications

References 14 publications

Antibiotic discovery in the twenty-first century: current trends and future perspectives

Antibiotic discovery in the twenty-first century: current trends and future perspectives

Proximicin A, B and C, Novel Aminofuran Antibiotic and Anticancer Compounds Isolated from Marine Strains of the Actinomycete Verrucosispora†

Description of Verrucosispora qiuiae sp. nov., isolated from mangrove swamp sediment, and emended description of the genus Verrucosispora

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