Abstract TMP6: NIH Stroke Scale as the Primary Outcome Measure for Trials of Acute Treatment of Ischemic Stroke

Chalos, Vicky; Ende, Nadinda A.M. van der; Lingsma, Hester F.; Mulder, Maxim J.H.L.; Venema, Esmée; Dijkland, Simone A.; Berkhemer, Olvert A.; Yoo, Albert J.; Broderick, Jospeh P; Palesch, Yuko Y.; Yeatts, Sharon D.; Roos, Yvo B.W.E.M.; Oostenbrugge, Robert J. van; Zwam, Wim van; Majoie, Charles B. L. M.; Lugt, Aad van der; Roozenbeek, Bob; Dippel, Diederik W.J.

doi:10.1161/str.50.suppl_1.tmp6

Cited by 75 publications

(91 citation statements)

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“…The NIHSS is a common neurological function score used to determine the prognosis of patients with cerebral infarction at admission [37][38][39]. The NIHSS can be used to objectively re ect the severity of cerebral infarction and determine patient prognosis [37][38][39]. Still, it has limitations [40] that could not be controlled for in the present study.…”

Section: Discussionmentioning

confidence: 99%

Association of MMP-9, ADMA, and sCD40L with ischemic stroke and correlations with stroke severity: A case-control study

Wang

Gao

2021

Preprint

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Background In the present study, we aimed to examine the correlation of serum levels of MMP-9, ADMA, and sCD40L with the occurrence and severity of acute ischemic stroke. Methods All routines analyses were performed using a Cobas platform. MMP-9, ADMA, and sCD40L were measured using ELISA kit. Results Compared with the controls, the stroke group showed higher MMP-9,higher sCD40L and higher ADMA. There were significant positive correlations between the NIHSS scores and MMP-9, sCD40L and ADMA. Conclusions Our study indicated that serum levels of MMP-9, sCD40L, and ADMA are associated with ischemic stroke and are correlated with the NIHSS scores at admission.

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Section: Discussionmentioning

confidence: 99%

Association of MMP-9, ADMA, and sCD40L with ischemic stroke and correlations with stroke severity: A case-control study

Wang

Gao

2021

Preprint

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“…Under the NIHSS system, 0 indicates normal stroke, 1‐4 mild, 5‐14 moderate, 15‐20 moderate to severe, and ≥21 severe stroke 11,12 . Under the mRS system, 0‐2 points indicate functional independence, 3‐5 points represent dependency, and a score of 6 indicates death 12,13 . Stroke in individuals under 50 years of age was evaluated as young stroke 14 …”

Section: Methodsmentioning

confidence: 99%

Clinical‐epidemiological and radiological characteristics of stroke patients: A multicentre study

Kunt

Cinar

Yüksel

et al. 2021

Int J Clinical Practice

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Introduction and Aim Stroke is the leading cause of disability in adults and the second most common cause of death, at a rate of 11.8% worldwide. The purpose of this study was to examine the aetiological, demographic, and clinical characteristics of patients admitted to hospital because of acute strokes. Materials and Methods This multicentre study retrieved information for all patients admitted to hospital because of an acute cerebrovascular event over a six‐month period, and sociodemographic, aetiological, and clinical characteristics were recorded. Results A total of 1136 patients, 520 of whom were women (45.7%), with a mean age of 70.3 ± 12.8 years, were included in the study. Of these, 967 were diagnosed with ischaemic stroke (IS) (85.1%), 99 with haemorrhagic stroke (HS) (8.7%), and 70 with transient ischaemic attack (6.1%). The most common risk factor for stroke was hypertension (73%). Carotid disease and hyperlipidaemia rates were higher in patients with HS. Numbers of functionally dependent patients with severe neurological status according to the National Institutes of Health Stroke Scale and modified Rankin scale were significantly higher in the HS group (P < .001). When IS was classified according to the Trial of Org 10172 in Acute Stroke Treatment, small vessel disease emerged as the most common cause (41%). The most common lesion localisations were the parietal lobe (23%) in the IS group and the thalamus (35.3%) in the HS group. Eighty‐eight patients (7.7%), 62 (6.4%) in the ischaemic subgroup, and 26 (26.3%) in the haemorrhagic subgroup, died within the first month. Conclusion Current and accurate evaluations of stroke aetiology are essential for stroke prevention and treatment planning. This study, shows that no change occurred in the aetiology of stroke and epidemiological characteristics and that accurate identification of modifiable stroke risk factors is still a major goal.

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“…e results of positron emission tomography (PET) [15,16] were used as the gold standard to evaluate the application value of the two tests. is study has been approved by the medical ethics committee of the hospital, and all patients and their families signed informed consent.…”

Section: Research Objectsmentioning

confidence: 99%

Deep Learning‐Based Diffusion‐Weighted Magnetic Resonance Imaging in the Diagnosis of Ischemic Penumbra in Early Cerebral Infarction

Sheng

Xue-ling

Jiang

et al. 2022

Contrast Media & Molecular Imaging

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The prefiltered image was imported into the local higher-order singular value decomposition (HOSVD) denoising algorithm (GL-HOSVD)-optimized diffusion-weighted imaging (DWI) image, which was compared with the deviation correction nonlocal mean (NL mean) and low-level edge algorithm (LR + edge). Regarding the peak signal-to-noise ratio (PSNR), root mean square error (RMSE), sensitivity, specificity, accuracy, and consistency, the application effect of the GL-HOSVD algorithm in DWI was investigated, and its adoption effect in the examination of ischemic penumbra (IP) of early acute cerebral infarction (ACI) patients was evaluated. A total of 210 patients with ACI were selected as the research subjects, who were randomly rolled into two groups. Those who were checked by conventional DWI were set as the control group, and those who used DWI based on the GL-HOSVD denoising algorithm were set as the observation group, with 105 people in each. Positron emission tomography (PET) test results were set as the gold standard to evaluate the application value of the two examination methods. It was found that under different noise levels, the peak signal-to-noise ratio (PSNR) of the GL-HOSVD algorithm and the root mean square error (RMSE) of the FA parameter were better than those of the nonlocal means (NL-means) of deviation correction and low-rank edge algorithm (LR + edge). The sensitivity, specificity, accuracy, and consistency (8.76%, 81.25%, 87.62%, and 0.52) of the observation group were higher than those of the control group (57.78%, 53.33%, 57.14%, and 0.35) ( P < 0.05 ). Moreover, the apparent diffusion coefficient (ADC) of the DWI images of the observation group was basically consistent with that of the PET images, while the control group had a poor display effect and low definition. In summary, under different noise levels, the GL-HOSVD algorithm had a good denoising effect and greatly reduced fringe artifacts. DWI after denoising had high sensitivity, specificity, accuracy, and consistency in the detection of IP, which was worthy of clinical application and promotion.

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Abstract TMP6: NIH Stroke Scale as the Primary Outcome Measure for Trials of Acute Treatment of Ischemic Stroke

Cited by 75 publications

References 0 publications

Association of MMP-9, ADMA, and sCD40L with ischemic stroke and correlations with stroke severity: A case-control study

Association of MMP-9, ADMA, and sCD40L with ischemic stroke and correlations with stroke severity: A case-control study

Clinical‐epidemiological and radiological characteristics of stroke patients: A multicentre study

Deep Learning‐Based Diffusion‐Weighted Magnetic Resonance Imaging in the Diagnosis of Ischemic Penumbra in Early Cerebral Infarction

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