Abstract 11374: Characterization and Prevalence of Ventricular Aneurysms in Patients with Chagas Disease by CMR

Abstract

Introduction: Ventricular aneurysms (VA′s) are common in patients with Chagas disease (CD). However, its prevalence in this population is not well defined. We aim to determine the prevalence and characteristics of VA′s in CD patients using cardiac magnetic resonance (CMR). Methods: We performed CMR in a cohort of CD patients and no history of CAD. We included patients older than 18 years with positive CD serology and analyzed their clinical and CMR variables. VA′s were classified according to their location and the apical ones were subclassified as follows: Microaneurysms (limited to the segment AHA-17), macroaneurysms (with extension to apical segments) and giant aneurysms (with extension to midventricular segments). These findings were noticed during cine and late gadolinium enhancement (LGE) sequences (figure 1). Results: A total of 113 patients were included, of whom 57% were women, with a median age of 60 years. VA′s were more common in the apex (96%) vs the infer-lateral wall (4%) with a total prevalence of 23%. Among the 3 VA′s subtypes, macroaneurysm was the most common (48%) followed by microaneurysm (36%) and giant aneurysm (16%). Patients with VA′s had lower LVEF and higher ventricular volumes compared to those without VA′s. LGE was more frequent and had a larger extension in patients with VA′s (Table 1). Ventricular thrombi were identified in 15% of the patients with VA′s. Conclusions: In our cohort of CD patients, almost a quarter of the population presented with VA′s during CMR and most of them were located in the apical segments. Of these, macroaneurysm was the most frequent subtype followed by microaneurysm. VA’s are associated with ventricular thrombi in this population.