Absorption, Transport and Distribution of Copper

Bremner, I.

doi:10.1002/9780470720622.ch3

Cited by 29 publications

(7 citation statements)

References 48 publications

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“…1A). It is widely considered that Zn levels in the liver are extremely important for controlling the synthesis and degradation of MT in most animal species (Bremner, 1980); MT concentrations in the hepatocyte are very low in Zn-deficient animals, and MT synthesis appears to be strongly stimulated by Zn supplementation of pig diets (Carlson et al, 1999;Martinez et al, 2004). In contrast, Cu is a poor inducer of MT synthesis; although it has been demonstrated that Cu can induce MT synthesis in laboratory animals, this only happens when very large doses are administrated (such as by intraperitoneal injection) and no Cu-MT accumulation was observed in the liver of Zn-deficient rats, pigs or sheep receiving Cu supplements for several weeks (Bremner, 1979).…”

Section: Resultsmentioning

confidence: 99%

“…It is thought that MTs play a major role in Cu excretion through the bile (Bremner, 1980), which explains pigs' marked resistance to chronic Cu toxicity in comparison with other groups such as ruminants, in which MT concentrations are lower and their capacity to bind Cu for excretion into the bile is very limited (Bremner, 1986;Bremner and Beattie, 1995). However, although it has been suggested that MTs may play a major role in Cd accumulation in pigs receiving diets supplemented with Cu, the involvement of MTs in Cd retention in pigs has not been empirically investigated.…”

Section: Introductionmentioning

confidence: 99%

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The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

López‐Alonso¹,

Benedito²,

García‐Vaquero³

et al. 2012

Livestock Science

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a b s t r a c tThis study investigated the involvement of metallothionein (MT) in hepatic and renal cadmium (Cd) accumulation and the interactions of this element with the essential elements copper (Cu) and zinc (Zn) in pigs receiving diets with or without Cu and Zn supplementation, in intensive and extensive production systems respectively. Animals from intensive systems showed significantly higher Cd concentrations in the liver (83.3 mg/ kg wet weight) and kidney (343 mg/kg) than animals from extensive systems (33.2 and 130 mg/kg respectively). Cu (liver 16.9, kidney 5.52 mg/kg) and Zn (82.8 and 29.7 mg/kg) concentrations were also significantly higher in pigs from intensive than in animals from extensive systems (Cu 10.1 and 4.64 mg/kg, Zn 66.2 and 23.1 mg/kg). Pigs from intensive systems showed 50% higher kidney MT concentrations than animals from extensive systems (278 and 183 mg/kg respectively), whereas liver MT concentrations were very similar in the two groups (1696 and 1517 mg/kg respectively). MT concentrations in both the liver and the kidney were strongly dependent on the Zn status of the animal. In the liver neither Cu nor Cd displaced Zn from MT, and the proportion of MT binding sites apparently occupied by Cu and Cd decreased with increasing hepatic MT concentration, despite the fact that both Cu and Cd have higher affinity for MT than Zn. The proportion of MT binding sites occupied by Cu and Cd was also directly related to Zn:Cu ratio in hepatic cells. In the kidney, in contrast, Cu seems able to compete with Zn for MT binding sites, and the proportion of MT binding sites occupied by Cu increased with increasing renal MT concentration.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

López‐Alonso¹,

Benedito²,

García‐Vaquero³

et al. 2012

Livestock Science

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“…This saturable mechanism explains why there were no significant differences in blood Zn concentrations between animals receiving the Zn-balanced basal diet (C and Cu groups) and those receiving the different Zn doses. Although Cu cannot synthesize MT in the gut, it effectively competes with Zn for the binding positions, resulting in low Cu absorption and, consequently, in secondary Cu deficiency in animals exposed to high dietary levels of Zn [43]. In this context, the competitive interaction may be a useful means of reducing Cu absorption in animals exposed to high levels of Cu.…”

Section: Discussionmentioning

confidence: 99%

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Minervino

López‐Alonso

Júnior

et al. 2018

Animals

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Simple SummarySheep are susceptible to copper toxicosis, a deadly disease that usually occurs when the animals ingest large amounts of this mineral. Considering that the susceptibility of sheep to copper accumulation varies widely among breeds and from animal to animal., we evaluate whether Zn supplementation could be an option as a preventive measure to protect against hepatic Cu accumulation in sheep. Zn at 300 mg/kg dry matter (DM) is useful for preventing excessive hepatic Cu accumulation. Hepatic Cu accumulation is lower in animals receiving the Zn supplementation.AbstractThe aim of this study was to evaluate whether zinc (Zn) supplementation protects against hepatic copper (Cu) accumulation in copper-loaded sheep. Forty cross-bred lambs were assigned to five experimental groups. These included the control group (C) and four treatment groups that received Cu and/or Zn supplementation (dry matter (DM) basis) over 14 weeks, as follows: Cu (450 mg Cu/kg); Zn-35 (450 mg Cu + 35 mg Zn/kg); Zn-150 (450 mg Cu + 150 mg Zn/kg); and Zn-300 (450 mg Cu + 300 mg Zn/kg). Blood, liver, and bile samples were obtained for mineral determination by inductively coupled plasma optical emission spectrometry (ICP–OES). The hepatic metallothionein (MT) concentrations were also determined. At the end of the experiment, hepatic Cu concentrations were higher in all Cu-supplemented groups than in C. Hepatic Cu accumulation was lower in the groups receiving the Zn supplementation than in the Cu group, although the difference was only statistically significant (66%) in the Zn-300 group. The MT concentrations tended to be higher (almost two-fold) in the Zn groups (but were not dose related) than in the C and Cu groups, and they were related to hepatic Zn concentrations. Zn supplementation at 300 mg/kg DM is useful for preventing excessive hepatic Cu accumulation in sheep exposed to high dietary concentrations of Cu.

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“…Vitamin E represents eight isomers of fat-soluble compounds (α-, β-, γ-,δ-tocopherol and tocotrienol) metabolized in plants (Bjorneboe, Bjorneboe, & Drevon, 1990;Helmut, Wilhelem, & Alfred, 1992;Netscher, 2007), available in various concentrations in fat-rich foods (edible oils and seeds) (Reboul et al, 2006;Yanishlieva & Marinova, 2001). α-Tocopherol (Pryor, 2000) is appreciated for cytoprotective nature, anti-inflammatory, and liver protection (Galli et al, 2017), and also considered as potential AA and immune system booster, to fight against viruses and pathogenic bacteria (Traber & Atkinson, 2007).…”

Section: α-Tocopherolmentioning

confidence: 99%

Review on nutritional composition of orange‐fleshed sweet potato and its role in management of vitamin A deficiency

Satheesh

Fanta

2019

Food Science & Nutrition

158

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A wide variety of the roots and tubers plays a major role in human diet, animal feed, and industrial raw materials. Sweet potatoes (SPs) play an immense role in human diet and considered as second staple food in developed and underdeveloped countries. Moreover, SP production and management need low inputs compared to the other staple crops. The color of SP flesh varied from white, yellow, purple, and orange. Scientific studies reported the diversity in SP flesh color and connection with nutritional and sensory acceptability. Among all, orange‐fleshed sweet potato (OFSP) has been attracting food technologists and nutritionists due to its high content of carotenoids and pleasant sensory characteristics with color. Researchers reported the encouraging health effects of OFSP intervention into the staple food currently practicing in countries such as Uganda, Mozambique, Kenya, and Nigeria. Scientific reviews on the OFSP nutritional composition and role in vitamin A management (VAM) are hardly available in the published literature. So, this review is conducted to address the detailed nutritional composition (proximate, mineral, carotenoids, vitamins, phenolic acids, and antioxidant properties), role in vitamin A deficiency (VAD) management, and different food products that can be made from OFSP.

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Absorption, Transport and Distribution of Copper

Cited by 29 publications

References 48 publications

The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

The involvement of metallothionein in hepatic and renal Cd, Cu and Zn accumulation in pigs

Dietary Zinc Supplementation to Prevent Chronic Copper Poisoning in Sheep

Review on nutritional composition of orange‐fleshed sweet potato and its role in management of vitamin A deficiency

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