Absorption of some organochlorine compounds by the rat small intestine—In vivo

Turner, John; Shanks, V.

doi:10.1007/bf01608169

Cited by 13 publications

(5 citation statements)

References 6 publications

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“…Oral exposure and subsequent absorption by the organism through the stomach and intestines are considered as the most important route of entry of DDT in humans. Then, DDT and its metabolites are transported via binding to blood plasma proteins and distributed in all body tissues based on their fat content [36][37][38][39]. DDT is primarily bio-transformed by the liver into two main intermediate metabolites: dichlorodiphenyldichloroethylene (DDE) [40,41] and dichloro-diphenyl-dichloroethane (DDD) [42].…”

Section: Toxicokinetics Of Main Pops and Their Metabolitesmentioning

confidence: 99%

Adverse effects of weight loss: Are persistent organic pollutants a potential culprit?

Rouhou

Karelis

St-Pierre

et al. 2016

Diabetes & Metabolism

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Section: Toxicokinetics Of Main Pops and Their Metabolitesmentioning

confidence: 99%

Adverse effects of weight loss: Are persistent organic pollutants a potential culprit?

Rouhou

Karelis

St-Pierre

et al. 2016

Diabetes & Metabolism

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“…Extremely hydrophobic compounds such as PCBs are assumed to go along with the cellular pathway for lipid assimilation. Lipids are transported through the cells via very low-density lipoproteins (23,24), and subsequently enter the lymph flow (9,24,25). Although the cell line presently used expresses some lipid transport, the extent is probably not fully comparable to in vivo conditions (26).…”

Section: Resultsmentioning

confidence: 99%

Availability of Polychlorinated Biphenyls (PCBs) and Lindane for Uptake by Intestinal Caco-2 Cells

Oomen¹,

Tolls²,

Kruidenier³

et al. 2001

Environmental Health Perspectives

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ArticlesChildren may ingest contaminated soil from hand to mouth. To assess this exposure route, we need to know the oral bioavailability of the contaminants. Two determining steps in bioavailability of soil-borne contaminants are mobilization from soil during digestion, which is followed by intestinal absorption. The first step has been investigated in previous studies that showed that a substantial fraction of PCBs and lindane is mobilized from soil during artificial digestion. Furthermore, almost all contaminants are sorbed to constituents of artificial human small intestinal fluid (i.e., chyme), whereas only a small fraction is freely dissolved. In this study, we examine the second step using intestinal epithelial Caco-2 cells. The composition of the apical exposure medium was varied by addition of artificial chyme, bile, or oleic acid at similar or increasing total contaminant concentrations. The uptake curves were described by rate constants. The uptake flux seemed to be dose-dependent. Furthermore, different exposure media with similar total contaminant concentrations resulted in various uptake rates. This can be attributed to different freely dissolved concentrations and carrier effects. In addition, the large fractions of contaminants in the cells indicate that PCBs and lindane sorbed to bile, oleic acid, and digestive proteins contributed to the uptake flux toward the cells. These results can be extrapolated qualitatively to in vivo conditions. Because the sorbed contaminants should be considered available for absorption, the first step of mobilization from soil is the most important step for oral bioavailability of the presently investigated soil-borne contaminants. Key words: bile, bioavailability, fatty acid, freely dissolved concentration, intestinal absorption, lindane, PCB, protein, soil-borne contaminant. Environ Health Perspect 109:731-737 (2001). [Online 11 July 2001] http://ehpnet1.niehs.nih.gov/docs/2001/109p731-737oomen/abstract.html

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“…Furthermore, the proposed model used blood transport as the only advection pathway to distribute pesticides in livestock bodies (tissues and organs). However, some chemical compounds (e.g., hydrophilic pesticides with high surface tension) are found to be also transported in a considerable manner via lymphatic or nervous systems, 62,63 which could lead to underestimation of residue levels in lymphoid organs. Therefore, additional advective transport pathways via lymphatic or nervous systems are needed to be considered in the PBK model for hydrophilic compounds, which can be achieved by adding respective dimensions in the proposed matrix.…”

Section: Papermentioning

confidence: 99%

Screening of pesticide distributions in foods of animal origin: a matrix-based approach for biotransfer factor modeling of grazing mammals

Xiong

Fantke

2022

Environ. Sci.: Processes Impacts

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Absorption of some organochlorine compounds by the rat small intestine—In vivo

Cited by 13 publications

References 6 publications

Adverse effects of weight loss: Are persistent organic pollutants a potential culprit?

Adverse effects of weight loss: Are persistent organic pollutants a potential culprit?

Availability of Polychlorinated Biphenyls (PCBs) and Lindane for Uptake by Intestinal Caco-2 Cells

Screening of pesticide distributions in foods of animal origin: a matrix-based approach for biotransfer factor modeling of grazing mammals

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