Absorption of Flavonols Derived from Sea Buckthorn (Hippophaë rhamnoides L.) and Their Effect on Emerging Risk Factors for Cardiovascular Disease in Humans

Abstract

Sea buckthorn (Hippophaë rhamnoides L.) is a rich source of flavonols, especially isorhamnetin. Most prospective cohort studies have indicated some degree of inverse association between flavonoid intake and coronary heart disease. Animal and human studies suggest that sea buckthorn flavonoids may scavenge free radicals, lower blood viscosity, and enhance cardiac function. The effects of flavonol aglycones derived from sea buckthorn on the risk factors of cardiovascular disease as well as their absorption were studied in humans. The flavonols, ingested with oatmeal porridge, did not have a significant effect on the levels of oxidized low-density lipoprotein, C-reactive protein, and homocysteine, on the plasma antioxidant potential, or on the paraoxonase activity. Flavonols at two dosages in oatmeal porridge were rapidly absorbed, and a relatively small amount of sea buckthorn oil added to the porridge seemed to have increased the bioavailability of sea buckthorn flavonols consumed at the higher dose.

Postprandial hyperglycemia and insulin response are affected by sea buckthorn (Hippophaë rhamnoides ssp. turkestanica) berry and its ethanol-soluble metabolites

“…Synergism might be due to the previously established ability of the sea buckthorn lipids to enhance the absorption of the sea buckthorn flavonoids (Suomela et al, 2006). When consumed in modest quantities that can easily be obtained from berries and berry products, insoluble berry fiber did not seem to affect postprandial glucose metabolism.…”

Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceutics and its therapeutic possibilities - a review

“…The abovementioned effects are probably achieved by reduced blood glucose concentrations, absorption of free radicals (Suomela et al 2006), reduced susceptibility of low-density lipoproteins to oxidation (Eccleston et al 2002) and anti-hypertensive effect (Wang et al 2011). …”

Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K

“…3 0 -Methoxy-3,4 0 ,5,7-tetrahydroxyflavone (i.e., isorhamnetin) is an active compound in herbal medicinal plants, such as Persicaria thunbergii H. and gross Hippophae rhamnoides L., and it has been used to treat cardiovascular disease, rheumatism, and hemorrhage (14)(15)(16). Recent studies have shown that isorhamnetin exerts anticancer effects.…”