Absorption, metabolism and excretion by goldfish of the anionic detergent sodium lauryl sulphate

Bioconcentration, biotransformation, and chronic toxicity of sodium laurate to zebrafish (Danio rerio)

“…Assuming both surfactants have the same mode of toxic action, this suggests that the hydrophobicity of these substances is similar. Like sodium laurate, SDS is readily metabolized by fish [19]. A possible explanation for the difference in the extent of bioaccumulation between these surfactants may lie in the relative extent and rates of metabolism.…”

Interactions between vascular actions of detergent and catecholamines in perfused gills of European eel, Anguilla anguilla L. and brown trout, Salmo trutta L.

“…These data strongly suggest that the detergent is indeed interfering with the noradrenaline response. If 2.1 O-'M LAS completely inhibits noradrenaline action then exposure of fish to water containing 1 mg/l (c. 3 * 1 0 -6~) detergent is likely to result in interference with adrenergic control mechanisms, since detergents pass rapidly across fish gills (Tovell, Howes & Newsome, 1975;Granmo & Kollberg, 1976).…”

“…Very low detergent concentrations affect the vascular tone of isolated perfused gills of eels, trout and Pacific salmon and influence the responses of the gills to catecholamines (Bolis & Rankin, 1975;1978). In these experiments the detergent was added to the perfusing solution rather than to the water in which the gills were suspended, since detergents pass rapidly through fish gills (Tovell, Howes & Newsome, 1975;Granmo & Kollberg, 1976) and complicating factors such as the effect of water hardness on detergent uptake (Tovell, Newsome & Hughes, 1974) can thereby be avoided. In the present study the use of this technique was continued to gain information on the interactions between detergents and catecholamines, but studies were also conducted on gills of fish which had been exposed to low detergent concentrations.…”

Vascular effects of acetylcholine, catecholamines and detergents on isolated perfused gills of pink salmon, Oncorhynchus gorbuscha coho salmon, O. kisutch and chum salmon, O. keta

“…The LAS was added to the perfusate, rather than to the solution bathing the gill, since it was known that detergents diffuse rapidly into gills (Granmo & Kollberg, 1976) and that within 24 h the total body concentration can exceed that of the external medium by 50% (Tovell, Howes & Newsome, 1975). Furthermore, the rate of absorption varies with the bivalent ion concentration of both the water bathing the gill and the water in which the fish had previously been living (Tovell, Newsome & Howes, 1974).…”