Absorption efficiency and excretion profile of a prolonged‐action form of chlorpromazine

Sugerman, A. Arthur; Rosen, Earl

doi:10.1002/cpt196455561

Cited by 11 publications

(1 citation statement)

References 4 publications

(5 reference statements)

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“…In Table II the data indicate that Spacetabs deliver the same amount of drug for absorption as do regular tablets or liquid concentrate. Similar findings have been reported with sustained-release medications of chlorpromazine 15 and of prochlorperazine. 1 Fig.…”

Section: Resultssupporting

confidence: 87%

Thioridazine blood levels in patients receiving different oral forms

Mellinger

Smith

1965

Clin Pharma and Therapeutics

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Phenothiazine drugs are considered by some as agents of short action and are therefore given in divided doses. "Timerelease" and "prolonged-action" preparations have been introduced with the idea of more, gradual release and a reduction in frequency of medication. Others, who 'consider phenothiazine tranquilizers as drugs of long action, do not recommend frequent dosage and consider sustained-release forms unnecessary.9 These views are explored in the present study. MethodsBlood concentration of thioridazine was determined by permanganometric fluorescence titrationY' 14 The method produces a characteristic spectrum highly specific for thioridazine.14 The smallest amount of the This study was supported in part by a grant from Sandoz Pharmaceuticals.Received for publication Nov. The relation between daily drug intake and blood concentration was investigated in 66 patients who gave four blood samples on one day only. They were under continuous treatment for more than two

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Section: Resultssupporting

confidence: 87%

Thioridazine blood levels in patients receiving different oral forms

Mellinger

Smith

1965

Clin Pharma and Therapeutics

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Behavioral Effects of Reducing the Daily Frequency of Phenothiazine Administration

Callahan¹

1975

Arch Gen Psychiatry

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Pharmacological Response Data for Comparative Bioavailability Studies of Chlorpromazine Oral Dosage Forms in Humans: I. Pupilometry

Smolen

Murdock

Stoltman

et al. 1975

The Journal of Clinical Pharma

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Owing to the insensitivity of even the presently best chemical or radiological assay procedures, it is not feasible to perform comparative bioavailability studies of chlorpromazine oral drug products using blood or urine sampling; this is particularly the case for oral doses below 100-150 mg/70 kg. In contrast, the use of temporal miotic response data, which correlates with blood levels of unchanged drug, permits dose-response vs time profiles to be recorded with oral dose levels as low as 5-10 mg/70 kg. The monitoring of pupilometric data in up to 16 human volunteers demonstrated a sensitivity to both extents and rates of chlorpromazine bioavailability and revealed differences to exist between liquid and solid oral dosage forms of chlorpromazine.

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Absorption efficiency and excretion profile of a prolonged‐action form of chlorpromazine

Abstract: In a rigidly controlled study, equal dosage regimens of chlorpromaZine (CPZ)

Cited by 11 publications

References 4 publications

Thioridazine blood levels in patients receiving different oral forms

Thioridazine blood levels in patients receiving different oral forms

Behavioral Effects of Reducing the Daily Frequency of Phenothiazine Administration

Pharmacological Response Data for Comparative Bioavailability Studies of Chlorpromazine Oral Dosage Forms in Humans: I. Pupilometry

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