Phenothiazine drugs are considered by some as agents of short action and are therefore given in divided doses. "Timerelease" and "prolonged-action" preparations have been introduced with the idea of more, gradual release and a reduction in frequency of medication. Others, who 'consider phenothiazine tranquilizers as drugs of long action, do not recommend frequent dosage and consider sustained-release forms unnecessary.9 These views are explored in the present study.
MethodsBlood concentration of thioridazine was determined by permanganometric fluorescence titrationY' 14 The method produces a characteristic spectrum highly specific for thioridazine.14 The smallest amount of the This study was supported in part by a grant from Sandoz Pharmaceuticals.Received for publication Nov. The relation between daily drug intake and blood concentration was investigated in 66 patients who gave four blood samples on one day only. They were under continuous treatment for more than two
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