Absolute Macrophage Requirement for T-Lymphocyte Activation by Mitogens

Polyclonal Antibody Production in Murine Spleen Cells Induced by Staphylococcus

“…Macrophages are capable of supporting mitogen-induced proliferation of T lymphocytes (17,29), but their roles in sustaining the polyclonal antibody synthesis of B lymphocytes are obscure. Moller and Landwall (18) reported that macrophages are not needed for the activation of polyclonal antibody synthesis by Cowan I strain bacteria or LPS.…”

Neutralization of mitogenic lectins by intravenous immunoglobulin (IVIg) prevents T cell activation: does IVIg really have a direct effect on T cells?

“…It is known that purified primary T cells cannot be activated by PHA alone, but also require essential signals from accessory cells [19][20][21]. We therefore used PBMC isolated from healthy volunteers to evaluate the effect of IVIg, IVIg-PHA and F(ab')2 fragments on primary T cell activation by PHA.…”

Effect of interleukin 1 on human thymocytes and purified human T cells.

“…Monocyte augmentation of lymphocyte proliferation has been documented with cells grown in suspension or soft agar culture, and cells stimulated with either mitogen or antigen (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). These data, demonstrating the need for both a stimulating mitogen and a growth-supporting accessory cell, suggest a possible requirement for multiple independent signals for optimal T cell proliferation.…”