Absolute lymphocyte count decreases with disease progression and is a potential prognostic marker for metastatic breast cancer

Jimbo, Hikari; Horimoto, Yoshiya; Ishizuka, Yumiko; Nogami, Noriko; Shikanai, Ayana; Saito, Mitsue; Watanabe, Junichiro

doi:10.1007/s10549-022-06748-4

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…In breast cancer, the absolute lymphocyte count gradually decreases with the progression of metastatic breast cancer. Monitoring changes in lymphocyte count in peripheral blood is a potential indicator for predicting recurrence [24]. In addition, peripheral blood lymphocyte counts are signi cantly positively correlated with Tumor-in ltrating lymphocytes in ltrating tumor tissue locally.…”

Section: Discussionmentioning

confidence: 99%

Elevated neutrophil-lymphocyte ratio predicts bone metastasis in esophageal cancer

Wang

Zhang

Chen

et al. 2023

Preprint

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Purpose Research on bone metastasis in esophageal cancer (EC) is relatively limited. Once bone metastasis occurs in patients, their prognosis is poor, and it severely affects their quality of life. Currently, there is a lack of convenient tumor markers for early identification of bone metastasis in EC. Our research aims to explore whether neutrophil-lymphocyte ratio (NLR) can predict bone metastasis in patients with EC. Methods Retrospective analysis of clinical indicators was performed on 604 patients with EC. They were divided into groups based on whether or not there was bone metastasis, and the patients' coagulation-related tests, blood routine, tumor markers and other indicators were collected. The receiver operating characteristic curve (ROC) were used to determine the predictive ability of parameters such as NLR for bone metastasis in EC, and univariate and multivariate logistic regression analyses were conducted to determine the impact of each indicator on bone metastasis. Using binary logistic regression to obtain the predictive probability of NLR combined with tumor markers. Results ROC curves analysis suggested that the area under the curve (AUC) of the NLR was 0.681, with a sensitivity of 79.2% and a specificity of 52.6%, which can be used as a predictive factor for bone metastasis in EC. Multivariate logistic regression analysis showed that high NLR (odds ratio [OR]: 2.608, 95% confidence interval [CI]: 1.395–4.874, P = 0.003) can function as an independent risk factor for bone metastasis in patients with EC. Additionally, high PT, high APTT, high FDP, high CEA, high CA724, low hemoglobin, and low platelet levels can also predict bone metastasis in EC. When NLR was combined with tumor markers, the area under the curve was 0.760 (95% CI: 0.713–0.807, P < 0.001), significantly enhancing the predictability of bone metastasis in EC. Conclusion NLR, as a convenient, non-invasive, and cost-effective inflammatory indicator, could predict bone metastasis in EC. Combining NLR with tumor markers can significantly improve the diagnostic accuracy of bone metastasis in EC.

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Section: Discussionmentioning

confidence: 99%

Elevated neutrophil-lymphocyte ratio predicts bone metastasis in esophageal cancer

Wang

Zhang

Chen

et al. 2023

Preprint

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“… 15 Lymphocyte count decrease is a sign of poor prognosis for cancer. 16 , 17 Low hemoglobin levels reflect tumor hypoxia, which can reduce the efficacy of radiotherapy. 18 Platelet is associated with metastasis, which can defend cancer cells from immune assault.…”

Section: Introductionmentioning

confidence: 99%

Nomogram Based on Hemoglobin, Albumin, Lymphocyte and Platelet Score to Predict Overall Survival in Patients with T3-4N0-1 Nasopharyngeal Carcinoma

Zhao¹,

Liang²,

Chen³

et al. 2023

JIR

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Purpose There is still uncertainty regarding the prognosis of nasopharyngeal carcinoma (NPC) based on hemoglobin, albumin, lymphocytes, and platelets (HALP) score. The aim of this study was to build and verify a nomogram using HALP score to investigate the prognostic value of NPC and identify low-risk patients in T3-4N0-1 NPC to guide treatment options. Patients and methods A total of 568 NPC patients with stage T3-4N0-1M0 were recruited in the study, who were given either concurrent chemoradiotherapy (CCRT) or induction chemotherapy (IC) plus CCRT. The prognostic factors of overall survival (OS) were picked by Cox proportional hazards regression analysis to generate a nomogram, which appraised by discrimination, calibration and clinical utility. Patients were stratified according to risk scores calculated by the nomogram, and compared to the 8th TNM staging system using the Kaplan–Meier methods. Results Multivariate analysis showed that TNM stage, Epstein–Barr virus DNA (EBV DNA), HALP score, lactate dehydrogenase-to-albumin ratio (LAR) and systemic inflammatory response index (SIRI) were independent prognostic indicators for OS, and these factors contained in the nomogram. The nomogram demonstrated a significant enhancement over the 8th TNM staging system in terms of assessing OS (C-index, 0.744 vs 0.615 in the training cohort, P < 0.001; 0.757 vs 0.646 in the validation cohort, P = 0.002). Calibration curves displayed good agreement and the stratification in high-risk and low-risk groups resulted in a significant divergence of Kaplan–Meier curves for OS (P < 0.001). In addition, the decision analysis (DCA) curves confirmed satisfactory discriminability and clinical utility. Conclusion The HALP score was an independent prognostic factor for NPC. The prognostic function of the nomogram for T3-4N0-1 NPC patients was more accurate compared to the 8th TNM system, facilitating personalized treatment planning.

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“…ALC can provide a surrogate measure of the host's inflammatory and immune responses given the critical role of lymphocytes in the tumor‐related immune response 5 . A number of studies have shown an association between lymphopenia and poor prognosis in cancers such as sarcoma, breast cancer, renal cancer, and gastric cancer 4,6–9 …”

Section: Introductionmentioning

confidence: 99%

“…5 A number of studies have shown an association between lymphopenia and poor prognosis in cancers such as sarcoma, breast cancer, renal cancer, and gastric cancer. 4,[6][7][8][9] However, the existing data on the reliability of ALC as a prognostic biomarker is mixed, with some studies showing inconsistent results regarding pretreatment lymphocyte counts. For instance, Punjabi et al showed no significant correlation between pretreatment ALC and survival outcomes in nonsmall cell lung cancer, although there was an association between postradiotherapy ALC and survival outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma

Shah

Liu

Shah

et al. 2023

Laryngoscope Investig Oto

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Objective(s)Absolute lymphocyte count (ALC) has been shown to be a prognostic indicator in other solid tumors. Given this, we aimed to evaluate the prognostic value of ALC in oral cavity squamous cell carcinoma (OSCC).MethodsUsing our institutional tumor registry data, we identified patients ≥18 years old who were diagnosed with OSCC between 2012 and 2018. Preoperative ALC values within 30 days of surgery were collected through retrospective chart review. American Joint Committee on Cancer, 7th‐edition best stage was used to categorize cancers as early stage (stages 1 and 2) or late‐stage (stages 3 and 4). Primary outcomes were likelihood of recurrence and survival rates after 3 years.ResultsOf the 412 patients identified, 262 patients had available ALC data and met inclusion criteria. Early stage cancer patients who had lymphopenia did not have any significant difference in their rate of death ([OR], 1.71, CI: 0.54–5.45, p = .36) or likelihood recurrence ([OR], 0.60, CI: 0.06–5.87, p = .66) after controlling for age, tobacco use, alcohol use, positive margins, and adjuvant therapy. Late‐stage cancer patients who had lymphopenia also showed no difference in their rate of death ([OR], 2.74, CI: 0.65–11.6, p = .17) or likelihood of recurrence ([OR], 0.38, CI: 0.04–3.36, p = .38).Conclusions and RelevanceThis study evaluates the prognostic value of ALC in oral cavity cancers. Our findings demonstrate that pretreatment ALC is not significantly associated with recurrence and survival outcomes patients with OSCC.Level of EvidenceIIILay SummaryAbsolute lymphocyte count (ALC) has been associated with prognosis in several cancers. We found that preoperative ALC was not associated with likelihood of survival or recurrence in patients with early stage or late‐stage oral cavity cancer.

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Absolute lymphocyte count decreases with disease progression and is a potential prognostic marker for metastatic breast cancer

Cited by 9 publications

References 25 publications

Elevated neutrophil-lymphocyte ratio predicts bone metastasis in esophageal cancer

Elevated neutrophil-lymphocyte ratio predicts bone metastasis in esophageal cancer

Nomogram Based on Hemoglobin, Albumin, Lymphocyte and Platelet Score to Predict Overall Survival in Patients with T3-4N0-1 Nasopharyngeal Carcinoma

Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma

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