Absolute Lymphocyte Count as an Independent Prognostic Factor in Metastatic Breast Cancer: A Retrospective Study

Abstract

Introduction Recently, absolute lymphocyte count (ALC) and neutrophil-to-lymphocyte ratio (NLR) have been reported to be prognostic and/or predictive factors in breast cancer. However, most of the investigations on the relationship between systemic inflammatory markers and prognosis have been conducted perioperatively, with few studies reporting on patients with metastatic or recurrent breast cancer (MBC). Here, we investigated the role of ALC and NLR as prognostic factors of MBC. Methods This was a retrospective observational study of patients with MBC treated at the University of Tsukuba Hospital between 2013 and 2020. ALC and NLR clinical data were obtained from the patients’ charts. Based on previous reports, the cutoff value of ALC was set at 1500/µL, and that of NLR, at 3. We investigated the prognostic significance of ALC and NLR. Results About 80% of the 243 included patients were hormone receptor-positive, 20% were HER2-positive and 10% were triple-negative. The patients were grouped as follows: 114 (46.9%) and 129 (53.1%) in the high and low ALC groups and 145 (59.7%) and 98 (40.3%) in the high and low NLR groups, respectively. The group with high ALC at diagnosis of MBC showed significantly better prognosis (p = 0.002), and the median overall survival (OS) was 70.9 months, as compared with 40.2 months for the low ALC group. On multivariate analysis, visceral metastasis, subtype and ALC were independent variables for OS; NLR status was not correlated with OS. Conclusions Analysis of real-world data suggests that ALC at diagnosis of MBC is an independent prognostic factor.

The prognostic value of absolute lymphocyte count and neutrophil‐to‐lymphocyte ratio for patients with metastatic breast cancer: a systematic review and meta‐analysis

“…After reviewing all the literature, 351 articles were included through screening of the title, abstract, and full text. Finally, 29 articles were included in this meta‐analysis after strict screening ( 18 – 20 , 24 – 49 ) ( Figure 1 ). The information of all the included literature was collected and pooled, and the basic characteristics are described in Table 1 .…”

Development and validation of a diagnostic model for predicting cervical lymph node metastasis in laryngeal and hypopharyngeal carcinoma

“…Although we initially considered NLR and PLR as potential predictive factors, they were not included in the final prediction model in the multivariate logistic regression analyses. While neutrophils and platelets play important roles in tumor metastasis ( 21 , 22 ), the roles of NLR and PLR in the field of cancer are still uncertain ( 23 – 25 ). While they showed a trend toward lymph node metastasis in univariate analysis, their impact was not as significant as tumor location, T stage, neutrophil count, and platelet count.…”