Absolute Configuration of Antifi brotic (+)-Episesamin Isolated from Lindera obtusiloba BLUME

Trowitzsch‐Kienast, Wolfram; Rühl, Martin; Kim, Ki Y.; Emmerling, Franziska; Erben, Ulrike; Somasundaram, Rajan; Freise, Christian

doi:10.1515/znc-2011-9-1004

Cited by 4 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 A recent in vitro study reported that episesamin, another sesame lignan, inhibits the TGF-beta expression without signicant cytotoxicity in rat hepatic stellate cells. 28 In this in vivo experiment, sesamin also suppressed the protein level and mRNA expression of TGF-b1 in the le ventricle of SHR. Taken together, these data indicate that another cause of the effect of sesamin on improving ventricular remodeling is attributed to the downregulation of TGF-b1.…”

Section: Protein Level and Mrna Expression Of Tgf-b1 In LVmentioning

confidence: 62%

Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats

Kong

Zhang

et al. 2013

Food Funct.

View full text Add to dashboard Cite

This study was designed to evaluate the in vivo cardioprotective effects of food-derived sesamin in spontaneously hypertensive rats (SHR). The study was performed with 17-week-old male normotensive Wistar-Kyoto rats (WKY) and SHR which are untreated or treated with orally administered sesamin for 16 weeks before they were sacrificed. Long-term treatment with sesamin obviously improved left ventricular (LV) hypertrophy and fibrosis in SHR, as indicated by the decrease of LV weight/body weight, myocardial cell size, cardiac fibrosis and collagen type I expression as well as the amelioration of the LV ultrastructure. These effects were associated with reduced systolic blood pressure, enhanced cardiac total antioxidant capability and decreased malondialdehyde content, nitrotyrosine level and transforming growth factor β1 (TGF-β1) expression. All these results suggest that chronic treatment with sesamin improves LV remodeling in SHR through alleviation of oxidative and nitrative stress, reduction of blood pressure and downregulation of TGF-β1 expression.

show abstract

Section: Protein Level and Mrna Expression Of Tgf-b1 In LVmentioning

confidence: 62%

Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats

Kong

Zhang

et al. 2013

Food Funct.

View full text Add to dashboard Cite

show abstract

“…In an in vitro study, (+)-episesamin isolated from a 70% ethanolic reaction showed antifibrotic activity. (+)-episesamin reduced the expression of profibrotic autocrine TGF-β, and therefore stopped the proliferation of hepatic stellate cell (HSC) without any significant cytotoxicity ( Table 2 ) [ 69 ]. In another in vivo study, a 70% ethanolic extract of LO showed remarkable hepatoprotection against tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats.…”

Section: Pharmacological Properties Of Lindera Obtusilobmentioning

confidence: 99%

Therapeutic Potential of Lindera obtusiloba: Focus on Antioxidative and Pharmacological Properties

Haque

Azam

Balakrishnan

et al. 2020

Plants

View full text Add to dashboard Cite

Lindera obtusiloba (LO) BLUME from the genus Lindera (Lauraceae) is a medicinal herb traditionally used in Southeast Asian countries. Indigenously, extracts of different parts of the plant have been used to improve blood circulation and treat allergy, inflammation, rheumatism, and liver diseases. LO is a rich source of therapeutically beneficial antioxidative phytochemicals, such as flavonoids, butenolides, lignans and neolignans. Moreover, recent studies have unravelled the pharmacological properties of several newly found active constituents of LO, such as anti-inflammatory antioxidants (+)-syringaresinol, linderin A, anti-atherosclerotic antioxidant (+)-episesamin, anti-melanogenic antioxidants quercitrin and afzelin, cytotoxic 2-(1-methoxy-11-dodecenyl)-penta-2,4-dien-4-olide, (2Z,3S,4S)-2-(11-dodecenylidene)-3-hydroxy-4-methyl butanolide, anti-allergic koaburaside, (6-hydroxyphenyl)-1-O-beta-d-glucopyranoside and 2,6-dimethoxy-4-hydroxyphenyl-1-O-beta-d-glucopyranoside and the antiplatelet-activity compound Secolincomolide A. These findings demonstrate that LO can be a potential source of antioxidants and other prospective therapeutically active constituents that can lead to the development of oxidative stress-mediated diseases, such as cardiovascular disorders, neurodegenerative disorders, allergies, inflammation, hepatotoxicity, and cancer. Here, the antioxidant properties of different species of Lindera genus are discussed briefly. The traditional use, phytochemistry, antioxidative and pharmacological properties of LO are also considered to help researchers screen potential lead compounds and design and develop future therapeutic agents to treat oxidative stress-mediated disorders.

show abstract

ALindera obtusilobaExtract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-κB

Freise

Kim

Querfeld

2015

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Vascular calcifications bear the risk for cardiovascular complications and have a high prevalence among patients with chronic kidney disease. Central mediators of vascular calcifications are vascular smooth muscle cells (VSMC). They transdifferentiate into a synthetic/osteoblast-like phenotype, which is induced, for example, by elevated levels of calcium and phosphate (Ca/P) due to a disturbed mineral balance. An aqueous extract from Lindera obtusiloba (LOE) is known to exert antifibrotic and antitumor effects or to interfere with the differentiation of preadipocytes. Using murine and rat VSMC cell lines, we here investigated whether LOE also protects VSMC from Ca/P-induced calcification. Indeed, LOE effectively blocked Ca/P-induced calcification of VSMC as shown by decreased VSMC mineralization and secretion of alkaline phosphatase. In parallel, mRNA expression of the calcification markers osterix and osteocalcin was reduced. Vice versa, the Ca/P-induced loss of the VSMC differentiation markers alpha smooth muscle actin and smooth muscle protein 22-alpha was rescued by LOE. Further, LOE blocked Ca/P-induced mRNA expressions and secretions of matrix metalloproteinases-2/-9 and activation of NF-κB, which are known contributors to vascular calcification. In conclusion, LOE interferes with the Ca/P-induced transdifferentiation/calcification of VSMC. Thus, LOE should be further analysed regarding a potential complementary treatment option for cardiovascular diseases including vascular calcifications.

show abstract

Absolute Configuration of Antifi brotic (+)-Episesamin Isolated from Lindera obtusiloba BLUME

Cited by 4 publications

References 17 publications

Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats

Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats

Therapeutic Potential of Lindera obtusiloba: Focus on Antioxidative and Pharmacological Properties

ALindera obtusilobaExtract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-κB

Contact Info

Product

Resources

About