Long-term intake of sesamin improves left ventricular remodelling in spontaneously hypertensive rats

Li, Wen‐Xing; Kong, Xiang; Zhang, Junxiu; Jie-ren, Yang

doi:10.1039/c2fo30220a

Cited by 18 publications

(17 citation statements)

References 31 publications

(37 reference statements)

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“…These findings are consistent with those from previous studies showing that sesamin decreases left ventricular remodeling in spontaneously hypertensive rats [30, 31]. Although sesamin has been reported the beneficial effects on hypertension [32], we did not observe a reducing blood pressure in TAC mice treated with sesamin.…”

Section: Discussionsupporting

confidence: 83%

Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS Pathway

Fan

Zheng

Liu

et al. 2017

Cell Physiol Biochem

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Background/Aims: Cardiac remodeling is associated with oxidative stress. Sesamin, a well-known antioxidant from sesamin seeds, have been used extensively as traditional health foods. However, there is little known about the effect of sesamin on cardiac remodeling. Therefore, the present study aimed to determine whether sesamin could protect against cardiac remodeling and to clarify potential molecular mechanisms. Methods: The mice were subjected to either transverse aortic constriction (TAC) or sham surgery (control group). Beginning one week after surgery, the mice were oral gavage treated with sesamin (100mg·kg^-1·day^-1) or vehicle for 3 weeks. Cardiac hypertrophy was assessed by echocardiographic parameters, histological analyses and hypertrophic markers. Results: Sesamin alleviated cardiac hypertrophy, inhibited fibrosis and attenuated the inflammatory response. The increased production of reactive oxygen species, the activation of ERK1/2-dependent nuclear factor-κB and the increased level of Smad2 phosphorylation were observed in cardiac remolding model that were treated with sesamin. Furthermore, TAC induced alteration of Sirt3 and SOD2 was normalized by sesamin treatment. Finally, a selective Sirt3 inhibitor 3-TYP blocks all the protective role of sesamin, suggesting that a Sirt3-dependent effect of sesamin on cardiac remodeling. Conclusion: Sesamin improves cardiac function and prevents the development of cardiac hypertrophy via Sirt3/ROS pathway. Our results suggest the protective effect of sesamin on cardiac remolding.

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Section: Discussionsupporting

confidence: 83%

Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS Pathway

Fan

Zheng

Liu

et al. 2017

Cell Physiol Biochem

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“…A report also demonstrated that the maximal left ventricular developed pressure (LVDP) is increased by the effect of β3-AR agonists in STZ-induced diabetic rats (24). However, the details of the association between sesamin and diabetic-induced cardiac hypertrophy remain.…”

Section: Methodsmentioning

confidence: 99%

“…GSE42693) was selected (23) for analyzing the potential signal transduction pathways in sesamin-treated rats compared with a group treated with a controlled diet. Previous studies have also demonstrated that sesamin can regulate fatty acid oxidation in rats, while other studies have reported that sesamin can recover left ventricular remodeling in spontaneously hypertensive rats (24). However, the association between diabetes-induced cardiac hypertrophy and sesamin is remains largely unknown.…”

Section: Introductionmentioning

confidence: 96%

Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

Thuy

Phan

Wang

et al. 2017

Molecular Medicine Reports

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Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.

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“…-actin was used as an internal control. The gene expression levels were normalized to the optical density of -actin in each sample [17].…”

Section: Reverse Transcription-polymerase Chain Reaction (Rt-pcr) Anamentioning

confidence: 99%

“…Like clonidine, it is an agonist of 2 -adrenergic receptors in certain parts of the brain [13]. It is found that dexmedetomidine dose-dependently attenuates extremely high mortality rates and increases in plasma cytokine concentrations after endotoxin injection and reduce NO level in hippocampal tissue to decrease neuron apoptosis in ischaemia-reperfusion brain injury of rats [14][15][16][17]. However, there has been no report to date about the effect of Dex on the nNOS-NO signalling in brain injury of ES rats.…”

Section: Introductionmentioning

confidence: 98%