ABSI vs BMI – Marker of obesity and its comorbities correlation

Kapoor, Rohit; Kapoor, Rishabh

doi:10.1016/j.ihj.2018.10.003

Cited by 2 publications

(3 citation statements)

References 0 publications

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“…The R wave amplitude in the V6 lead represents the electrical forces directed toward the lateral wall of the left ventricle. A higher amplitude might correlate with less scarring and better contractile reserve in the lateral wall, which could translate into a better response to CRT [70].…”

Section: Height Of R Wave In V6mentioning

confidence: 99%

Synchronizing Beats: From Theory to Advances and Insight in Cardiac Resynchronization Therapy

Almusaad,

AlTaweel,

Abdullatif Alarfaj

et al. 2024

Cardiology and Cardiovascular Medicine

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Cardiac resynchronization therapy (CRT) is an established treatment for select patients with systolic heart failure, left ventricular conduction delay, and dyssynchronous contraction. Landmark trials have shown CRT’s benefits on symptoms, exercise capacity, reverse remodeling, hospitalization rates, and mortality. However, limitations exist including sub-optimal patient selection, procedural complexity, high non-responder rates, and device-related adverse effects. This review summarizes the evolution, physiology, clinical trial evidence, patient selection, delivery, and optimization of CRT. Key areas covered include guidelines for CRT use, invasive and noninvasive imaging to improve outcomes, alternative pacing sites to enhance response, and advances in lead technology and implantation techniques. Gaps in current knowledge are highlighted along with future directions for research to refine CRT utilization and improve real-world clinical outcomes. With further studies to address remaining questions, CRT is poised to become an even more effective therapy for heart failure patients with dyssynchronous cardiomyopathy.

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Section: Height Of R Wave In V6mentioning

confidence: 99%

Synchronizing Beats: From Theory to Advances and Insight in Cardiac Resynchronization Therapy

Almusaad,

AlTaweel,

Abdullatif Alarfaj

et al. 2024

Cardiology and Cardiovascular Medicine

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“…On the other hand, most of the hormone-based activities in the liver (e.g. lipid-lowering) are mediated through TRβ activation ( 9 , 10 ). In fact, preclinical data using TRβ selective compounds show promising results in regulating lipogenesis and metabolism (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Despite this promise, surprisingly, the full spectrum of TH response in metabolic regulation has not been observed such as robust weight reduction in obese preclinical animal models. Indeed, small molecule thyromimetics are able to show lipid metabolism benefits, but poor TH-receptor selectivity and bioavailability have caused extrahepatic toxic effects and limited efficacy ( 2 , 10 ). Thus, it is clear that selective stimulation of TRβ is a promising approach in addressing many critical gaps in metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

Conferring liver selectivity to a thyromimetic using a novel nanoparticle increases therapeutic efficacy in a diet-induced obesity animal model

Wu,

Prachyathipsakul,

Zhuang

et al. 2023

PNAS Nexus

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Optimization of metabolic regulation is a promising solution for many pathologies, including obesity, dyslipidemia, type 2 diabetes, and inflammatory liver disease. Synthetic thyroid hormone mimics–based regulation of metabolic balance in the liver showed promise but was hampered by the low biocompatibility and harmful effects on the extrahepatic axis. In this work, we show that specifically directing the thyromimetic to the liver utilizing a nanogel-based carrier substantially increased therapeutic efficacy in a diet-induced obesity mouse model, evidenced by the near-complete reversal of body weight gain, liver weight and inflammation, and cholesterol levels with no alteration in the thyroxine (T4) / thyroid stimulating hormone (TSH) axis. Mechanistically, the drug acts by binding to thyroid hormone receptor β (TRβ), a ligand-inducible transcription factor that interacts with thyroid hormone response elements and modulates target gene expression. The reverse cholesterol transport (RCT) pathway is specifically implicated in the observed therapeutic effect. Overall, the study demonstrates a unique approach to restoring metabolic regulation impacting obesity and related metabolic dysfunctions.

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ABSI vs BMI – Marker of obesity and its comorbities correlation

Cited by 2 publications

References 0 publications

Synchronizing Beats: From Theory to Advances and Insight in Cardiac Resynchronization Therapy

Synchronizing Beats: From Theory to Advances and Insight in Cardiac Resynchronization Therapy

Conferring liver selectivity to a thyromimetic using a novel nanoparticle increases therapeutic efficacy in a diet-induced obesity animal model

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