Absence of thermoregulatory vasomotor responses during fast wave sleep in cats

Parmeggiani, Pier Luigi; Zamboni, Giovanni; Cianci, T; Calasso, M

doi:10.1016/0013-4694(77)90173-0

Cited by 60 publications

(24 citation statements)

References 32 publications

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“…Interestingly, both nonshivering and shivering thermogenesis and peripheral vasoconstriction are greatly attenuated, or even eliminated, during REM in most animal species (26,67), a time when 5-HT neurons, including those located in the caudal raphé, are at their lowest level of activity (32,35). These observations support the hypothesis of a state-related modulatory role for medullary 5-HT neurons in controlling shivering and thermoregulatory sympathetic activity.…”

Section: Methoxyphenyl)-1-piperazinyl]-supporting

confidence: 57%

Activation of 5-HT_1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Brown¹,

Sirlin²,

Benoit³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Activation of 5-HT 1A receptors in the medullary raphé decreases sympathetically mediated brown adipose tissue (BAT) thermogenesis and peripheral vasoconstriction when previously activated with leptin, LPS, prostaglandins, or cooling. It is not known whether shivering is also modulated by medullary raphé 5-HT 1A receptors. We previously showed in conscious piglets that activation of 5-HT 1A receptors with (Ϯ)-8-hydroxy-2-(dipropylamino)-tetralin (8-OH-DPAT) in the paragigantocellularis lateralis (PGCL), a medullary region lateral to the raphé that contains substantial numbers of 5-HT neurons, eliminates rapid eye movement (REM) sleep and decreases shivering in a cold environment, but does not attenuate peripheral vasoconstriction. Hoffman JM, Brown JW, Sirlin EA, Benoit AM, Gill WH, Harris MB, Darnall RA. Am J Physiol Regul Integr Comp Physiol 293: R518 -R527, 2007. We hypothesized that, during cooling, activation of 5-HT 1A receptors in the medullary raphé would also eliminate REM sleep and, in contrast to activation of 5-HT 1A receptors in the PGCL, would attenuate both shivering and peripheral vasoconstriction. In a continuously cool environment, dialysis of 8-OH-DPAT into the medullary raphé resulted in alternating brief periods of non-REM sleep and wakefulness and eliminated REM sleep, as observed when 8-OH-DPAT is dialyzed into the PGCL. Moreover, both shivering and peripheral vasoconstriction were significantly attenuated after 8-OH-DPAT dialysis into the medullary raphé. The effects of 8-OH-DPAT were prevented after dialysis of the selective 5-HT 1A receptor antagonist WAY-100635. We conclude that, during cooling, exogenous activation of 5-HT 1A receptors in the medullary raphé decreases both shivering and peripheral vasoconstriction. Our data are consistent with the hypothesis that neurons expressing 5-HT 1A receptors in the medullary raphé facilitate spinal motor circuits involved in shivering, as well as sympathetic stimulation of other thermoregulatory effector mechanisms. thermoregulation; serotonin; brain stem; raphé; the sudden infant death syndrome MANY NEURONS IN THE MEDULLARY raphé, including serotonergic (5-HT) neurons, project to the intermediolateral cell column (IML) of the spinal cord and modulate sympathetic outflow to thermoregulatory effector mechanisms, including brown adipose tissue (BAT) thermogenesis, vasoconstriction of thermoregulatory cutaneous vascular beds, and heart rate (HR) (14,53,58,86,89). Studies in anesthetized and conscious animals have shown that activation of 5-HT 1A receptors in the medullary raphé with the selective agonist, (Ϯ)-8-hydroxy-2-(dipropylamino)-tetralin (8-OH-DPAT), attenuates sympathetic outflow to BAT and peripheral vessels when previously elevated by LPS, leptin, or cooling (11,52,59,63,64).There is mounting evidence that medullary raphé 5-HT neurons modulate sympathetically mediated thermoregulatory mechanisms; however, little is known about the role of medullary raphé 5-HT neurons in shivering thermogenesis. Shivering is an involuntary tremor that i...

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Section: Methoxyphenyl)-1-piperazinyl]-supporting

confidence: 57%

Activation of 5-HT_1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Brown¹,

Sirlin²,

Benoit³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…Interestingly, both nonshivering and shivering thermogenesis and peripheral vasoconstriction are greatly attenuated, or even eliminated, during rapid eye movement (REM) sleep in most animal species (19,53), a time when 5-HT neurons are thought to be at their lowest level of activity (23,26). These observations support a state-related modulatory role for medullary 5-HT neurons in controlling thermoregulatory sympathetic activity.…”

mentioning

confidence: 91%

Activation of 5-HT_1Areceptors in the paragigantocellularis lateralis decreases shivering during cooling in the conscious piglet

Hoffman

Brown²,

Sirlin³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Activation of 5-HT(1A) receptors in the medullary raphé decreases sympathetic outflow to thermoregulatory mechanisms, including brown adipose tissue (BAT), thermogenesis, and peripheral vasoconstriction when these mechanisms are previously activated with leptin, prostaglandins, or cooling. These same mechanisms are also inhibited during rapid eye movement (REM) sleep. It is not known whether shivering is also modulated by medullary raphé neurons. We previously showed in the conscious piglet that activation of 5-HT(1A) receptors with 8-OH-DPAT (DPAT) in the paragigantocellularis lateralis (PGCL), a medullary region lateral to the midline raphé that contains 5-HT neurons, decreases heart rate, body temperature and muscle activity during non-rapid eye movement (NREM) sleep. We therefore hypothesized that activation of 5-HT(1A) receptors in the PGCL would also attenuate shivering and peripheral vasoconstriction during cooling. During REM sleep in a cool environment, shivering, carbon dioxide production, and body temperature decreased, and ear capillary blood flow and ear skin temperature increased. Shivering associated with rapid cooling was attenuated after dialysis of DPAT into the PGCL. In animals maintained in a continuously cool environment, dialysis of DPAT into the PGCL attenuated shivering and decreased body temperature, but there were no significant increases in ear capillary blood flow or ear skin temperature. We conclude that both naturally occurring REM sleep and exogenous activation of 5-HT(1A) receptors in the PGCL are associated with a suspension of shivering during cooling. Our data are consistent with the hypothesis that 5-HT neurons in the PGCL facilitate oscillating spinal motor circuits involved in shivering but are less involved in modulating sympathetically mediated thermoregulatory mechanisms.

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“…In the present study, RF-EMF exposure may have induced greater peripheral vascular conductance and thus a cardiovascular challenge. It is clear that the lower skin temperature involves arousal thermoregulatory processes, which oppose the maintenance of SWS [16], [28]. Thus, thermoregulation would be more efficient if the frequency of quiet W episodes increases.…”

Section: Discussionmentioning

confidence: 99%

Does Exposure to a Radiofrequency Electromagnetic Field Modify Thermal Preference in Juvenile Rats?

et al. 2014

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Some studies have shown that people living near a mobile phone base station may report sleep disturbances and discomfort. Using a rat model, we have previously shown that chronic exposure to a low-intensity radiofrequency electromagnetic field (RF-EMF) was associated with paradoxical sleep (PS) fragmentation and greater vasomotor tone in the tail. Here, we sought to establish whether sleep disturbances might result from the disturbance of thermoregulatory processes by a RF-EMF. We recorded thermal preference and sleep stage distribution in 18 young male Wistar rats. Nine animals were exposed to a low-intensity RF-EMF (900 MHz, 1 V.m−1) for five weeks and nine served as non-exposed controls. Thermal preference was assessed in an experimental chamber comprising three interconnected compartments, in which the air temperatures (Ta) were set to 24°C, 28°C and 31°C. Sleep and tail skin temperature were also recorded. Our results indicated that relative to control group, exposure to RF-EMF at 31°C was associated with a significantly lower tail skin temperature (−1.6°C) which confirmed previous data. During the light period, the exposed group preferred to sleep at Ta = 31°C and the controls preferred Ta = 28°C. The mean sleep duration in exposed group was significantly greater (by 15.5%) than in control group (due in turn to a significantly greater amount of slow wave sleep (SWS, +14.6%). Similarly, frequency of SWS was greater in exposed group (by 4.9 episodes.h−1). The PS did not differ significantly between the two groups. During the dark period, there were no significant intergroup differences. We conclude that RF-EMF exposure induced a shift in thermal preference towards higher temperatures. The shift in preferred temperature might result from a cold thermal sensation. The change in sleep stage distribution may involve signals from thermoreceptors in the skin. Modulation of SWS may be a protective adaptation in response to RF-EMF exposure.

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Absence of thermoregulatory vasomotor responses during fast wave sleep in cats

Cited by 60 publications

References 32 publications

Activation of 5-HT_1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Activation of 5-HT_1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Activation of 5-HT_1Areceptors in the paragigantocellularis lateralis decreases shivering during cooling in the conscious piglet

Does Exposure to a Radiofrequency Electromagnetic Field Modify Thermal Preference in Juvenile Rats?

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Absence of thermoregulatory vasomotor responses during fast wave sleep in cats

Cited by 60 publications

References 32 publications

Activation of 5-HT1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Activation of 5-HT1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Activation of 5-HT1Areceptors in the paragigantocellularis lateralis decreases shivering during cooling in the conscious piglet

Does Exposure to a Radiofrequency Electromagnetic Field Modify Thermal Preference in Juvenile Rats?

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Activation of 5-HT_1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Activation of 5-HT_1Areceptors in medullary raphé disrupts sleep and decreases shivering during cooling in the conscious piglet

Activation of 5-HT_1Areceptors in the paragigantocellularis lateralis decreases shivering during cooling in the conscious piglet