Does Exposure to a Radiofrequency Electromagnetic Field Modify Thermal Preference in Juvenile Rats?

Pelletier, Amandine; Delanaud, Stéphane; Seze, René de; Bach, Véronique; Libert, Jean‐Pierre; Loos, Nathalie

doi:10.1371/journal.pone.0099007

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…A whole-body exposure system was designed inside a climatic chamber for in vivo experiments to 900 MHz CW radiation. A detailed description of the RF exposure system has previously been published 4 . Briefly, a 900 MHz signal was generated from a radiofrequency power source type RFS7001800-6×0.5 (RFPA, Artigues-près-Bordeaux, France), located outside the climatic chambers and connected to a four-output divider which simultaneously supplied four antennas Kathrein 800-10465 (Rosenheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

Effect of non-thermal radiofrequency on body temperature in mice

Cuc

Delanaud

Bach

et al. 2020

Sci Rep

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Communication technologies based on radiofrequency (RF) propagation bring great benefits to our daily life. However, their rapid expansion raises concerns about possible impacts on public health. At intensity levels below the threshold to produce thermal effects, RF exposure has also recently been reported to elicit biological effects, resembling reactions to cold. The objective of the present study was to investigate the effects of non-thermal RF on body temperature in mice and the related mechanisms. 3-months-old C57BL/6 J mice were exposed to a continuous RF signal at 900 MHz, 20 ± 5 V.m −1 for 7 consecutive days, twice per day during the light phase, for one hour each time. The SAR was 0.16 ± 0.10 W.kg −1. We showed that body temperature patterns in mice change synchronously with the RF exposure periods. Average body temperature in the light phase in the exposed group was higher than in the control group. The expression of the TRPM8 gene was not affected by RF in trigeminal ganglia. Furthermore, the injection of a TRPM8 antagonist did not induce a temperature decrease in exposed mice, as this was the case for sham-controls. These findings indicate that 900 MHz RF exposure at non-thermal level produce a physiological effect on body temperature in mice. However, the involvement of TRPM8 receptors in the mechanism by which RF induced changes in body temperature of mice which remains to be further explored. It must then be assessed if this effect is extrapolable to man, and if this could lead to consequences on health. Radiofrequency (RF) is known to carry insufficient quantum energy to eject electrons from atoms, in contrast to energy of CT scans or X-rays in medical applications. However, RF energy can penetrate the body and induce an elevation of temperature in body tissues as used with the microwave oven technology that is referred to as thermal effects of RF. To protect humans from harmful effects induced by excessive tissue heating, safety limits of RF exposure were established and were described in regulatory guidelines, such as those from ICNIRP (International Commission on Non-Ionizing Radiation Protection) and IEEE (Institute of Electrical and Electronics Engineers) 1. Up to now, except for the microwave auditory effect 2 , the effects of RF at non-thermal levels remain unexplained, poorly reproducible and controversial. In recent years, studies revealed responses induced in rodents by chronic or repeated RF exposure at low intensity which were similar to those observed in cold conditions. Pelletier et al. demonstrated that rats repeatedly exposed (5 weeks, 23 hours per day) to RF at 900 MHz with an intensity of 1 V.m −1 at warm ambient temperature, had a subcutaneous tail temperature 1.2 °C lower than controls, due to maintained vasoconstriction 3. This cannot be explained by a classical dielectric absorption. Also, exposed rats ate more than controls and spent more time to sleep at an ambient temperature of 31 °C, whereas controls spent more time at 28 °C 4. These results led the authors to suggest th...

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Section: Methodsmentioning

confidence: 99%

Effect of non-thermal radiofrequency on body temperature in mice

Cuc

Delanaud

Bach

et al. 2020

Sci Rep

Self Cite

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“…The obtained results suggested that the exposure caused increased constriction of blood vessels, and increased food intake, but without any effects on sleep pattern. In the second study from the same group (Pelletier et al 2014), the same rat model and exposure conditions were used for thermal preference and sleep stage distribution studies. Exposed animals shifted their thermal preference after the exposure period towards higher temperatures.…”

Section: Other Effectsmentioning

confidence: 99%

Ecological study on the penetration of induction heating cookers and birth outcomes in Japan

et al. 2020

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About the Scientific CommitteesThree independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat.They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health and Environmental Risks (SCHER) and the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR).In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCENIHRThis Committee deals with questions related to emerging or newly identified health and environmental risks and on broad, complex or multidisciplinary issues requiring a comprehensive assessment of risks to consumer safety or public health and related issues not covered by other Community risk assessment bodies. Examples of potential areas of activity include potential risks associated with interaction of risk factors, synergic effects, cumulative effects, antimicrobial resistance, new technologies such as nanotechnologies, medical devices including those incorporating substances of animal and/or human origin, tissue engineering, blood products, fertility reduction, cancer of endocrine organs, physical hazards such as noise and electromagnetic fields (from mobile phones, transmitters and electronically controlled home environments), and methodologies for assessing new risks. It may also be invited to address risks related to public health determinants and non-transmissible diseases.

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“…Mechanistically, one may hypothesize that local skin thermal sensitivity was modulated in relationship to whole-body thermal states [ 32 ]. Indeed, RF-EMF exposures were previously shown to modify thermal perception or to increase whole temperature in rodents [ 33 , 34 ]. In addition, one may hypothesize that local skin thermal sensitivity was modulated through the chemical mediators influencing the higher-order midbrain regions controlling pain perception.…”

Section: Discussionmentioning

confidence: 99%

Effect of Radiofrequency Electromagnetic Fields on Thermal Sensitivity in the Rat

Ouadah

Blazy

Villegier

2020

IJERPH

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The World Health Organization and the French Health Safety Agency (ANSES) recognize that the expressed pain and suffering of electromagnetic field hypersensitivity syndrome (EHS) people are a lived reality requiring daily life adaptations to cope. Mechanisms involving glutamatergic N-methyl d-aspartate (NMDA) receptors were not explored yet, despite their possible role in hypersensitivity to chemicals. Here, we hypothesized that radiofrequency electromagnetic field (RF-EMF) exposures may affect pain perception under a modulatory role played by the NMDA receptor. The rats were exposed to RF-EMF for four weeks (five times a week, at 0 (sham), 1.5 or 6 W/kg in restraint) or were cage controls (CC). Once a week, they received an NMDA or saline injection before being scored for their preference between two plates in the two-temperatures choice test: 50 °C (thermal nociception) versus 28 °C. Results in the CC and the sham rats indicated that latency to escape from heat was significantly reduced by −45% after NMDA, compared to saline treatment. Heat avoidance was significantly increased by +40% in the 6 W/kg, compared to the sham exposed groups. RF-EMF effect was abolished after NMDA treatment. In conclusion, heat avoidance was higher after high brain-averaged specific absorption rate, affording further support for possible effect of RF-EMF on pain perception. Further studies need to be performed to confirm these data.

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Does Exposure to a Radiofrequency Electromagnetic Field Modify Thermal Preference in Juvenile Rats?

Cited by 12 publications

References 29 publications

Effect of non-thermal radiofrequency on body temperature in mice

Effect of non-thermal radiofrequency on body temperature in mice

Ecological study on the penetration of induction heating cookers and birth outcomes in Japan

Effect of Radiofrequency Electromagnetic Fields on Thermal Sensitivity in the Rat

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