Absence of Scleroderma pattern at nail fold capillaroscopy valuable in the exclusion of Scleroderma in unselected patients with Raynaud’s Phenomenon

Bissell, Lesley-Anne; Abignano, Giuseppina; Emery, Paul; Galdo, Francesco Del; Buch, Maya H

doi:10.1186/s12891-016-1206-5

Cited by 20 publications

(17 citation statements)

References 15 publications

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“…In our patient, NFC confirmed abnormalities compatible with late SS. The NFC’s associated high negative predictive value has great clinical importance in the exclusion of SS 13. NFC results suggestive of SS can be found in other connective tissue disorders, such as dermatomyositis and mixed CTD (MCTD) 12.…”

Section: Discussionmentioning

confidence: 99%

Systemic sclerosis: severe pulmonary arterial hypertension and pericardial effusion at diagnosis

Moniz¹,

Rei

Rodrigues

et al. 2018

BMJ Case Reports

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A 51-year-old female patient with a recent hospital admission reported to the emergency room (ER) with progressive worsening of fatigue, dyspnoea and chest discomfort. She had been recently admitted and discharged with the diagnosis of pericarditis and medicated with non-steroidal anti-inflammatory drugs and diuretics. She returned to the ER with persisting symptoms. Echocardiography was repeated and showed signs of elevated right ventricular systolic pressure and a slightly increased moderate/severe pericardial effusion without signs of cardiac tamponade. The patient was admitted and further evaluation confirmed an underlying case of advanced systemic sclerosis with skin, vascular, pulmonary and cardiac involvement. The patient was referred to specialised consults in autoimmune pathology and pulmonary arterial hypertension. She was started on bosentan and corticosteroids, presenting a favourable clinical evolution although symptoms of exertional dyspnoea persist.

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Section: Discussionmentioning

confidence: 99%

Systemic sclerosis: severe pulmonary arterial hypertension and pericardial effusion at diagnosis

Moniz¹,

Rei

Rodrigues

et al. 2018

BMJ Case Reports

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“…These are the group of patients who might be at a higher risk for developing connective tissue disease on follow-up. On the other hand, the absence of NFC abnormalities in a patient of Raynaud's is also helpful in the exclusion of scleroderma [11].…”

Section: Raynaud's Phenomenonmentioning

confidence: 99%

Nailfold Capillaroscopy in Rheumatic Diseases

Patil¹,

Sood²

2020

Vascular Biology - Selection of Mechanisms and Clinical Applications

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Nailfold capillaroscopy (NFC) has developed into an indispensable tool for rheumatologists in the evaluation of rheumatic diseases. It offers various advantages in being rapid, noninvasive, and inexpensive. With NFC we are able to visualize the microcirculatory changes in the nail beds. These changes are key to the pathogenesis of connective tissue diseases such as systemic sclerosis. Hence NFC helps in early diagnosis of various connective tissue diseases. There is a lack of standardization in the techniques used and various capillary parameters studied, which could lead to variation in the reporting of the parameters studied. In this chapter we shall try to highlight the most common parameters studied in capillaroscopy and its utility in various connective tissue diseases.

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“…A study analyzed the predictive value of the "SD" pattern for the diagnosis of SSc in a cohort of unselected patients. The results showed a sensitivity, specificity, PPV, and NPV of 71, 95, 84, and 90%, respectively (B) [76].…”

Section: Recommendationmentioning

confidence: 99%

Position article and guidelines 2018 recommendations of the Brazilian Society of Rheumatology for the indication, interpretation and performance of nailfold capillaroscopy

et al. 2019

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Nailfold capillaroscopy (NFC) is a reproducible, simple, low-cost, and safe imaging technique used for morphological analysis of nail bed capillaries. It is considered to be extremely useful for the investigation of Raynaud's phenomenon and for the early diagnosis of systemic sclerosis (SSc). The capillaroscopic pattern typically associated with SSc, scleroderma ("SD") pattern, is characterized by dilated capillaries, microhemorrhages, avascular areas and/or capillary loss, and distortion of the capillary architecture. The aim of these recommendations is to provide orientation regarding the relevance of NFC, and to establish a consensus on the indications, nomenclature, the interpretation of NFC findings and the technical equipments that should be used. These recommendations were formulated based on a systematic literature review of studies included in the database MEDLINE (PubMed) without any time restriction.

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Absence of Scleroderma pattern at nail fold capillaroscopy valuable in the exclusion of Scleroderma in unselected patients with Raynaud’s Phenomenon

Cited by 20 publications

References 15 publications

Systemic sclerosis: severe pulmonary arterial hypertension and pericardial effusion at diagnosis

Systemic sclerosis: severe pulmonary arterial hypertension and pericardial effusion at diagnosis

Nailfold Capillaroscopy in Rheumatic Diseases

Position article and guidelines 2018 recommendations of the Brazilian Society of Rheumatology for the indication, interpretation and performance of nailfold capillaroscopy

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