Absence of lymphatic vessels in the developing human sclera

Schlereth, Simona L.; Neuser, Barbara; Herwig, Martina C.; Müller, Annette; Koch, Konrad R.; Reitsamer, Herbert A.; Schrödl, Falk; Cursiefen, Claus; Heindl, Ludwig M.

doi:10.1016/j.exer.2014.06.010

Cited by 29 publications

(19 citation statements)

References 31 publications

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“…The most outer layer of the sclera, the episclera, contains a tight network of blood vessels, which is surrounded by LYVE1+ macrophages [32]. The fetal sclera is also alymphatic but, in contrast to the adult sclera, contains only few macrophages [33]. The exact function of these macrophages is not clear yet.…”

Section: The Lymphatic Vascular Anatomy Of the Eyementioning

confidence: 98%

Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: What can we learn from the eye?

Hos

Schlereth

Bock

et al. 2015

Seminars in Cell & Developmental Biology

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Section: The Lymphatic Vascular Anatomy Of the Eyementioning

confidence: 98%

Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: What can we learn from the eye?

Hos

Schlereth

Bock

et al. 2015

Seminars in Cell & Developmental Biology

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“…Das okuläre Melanom bietet die einzigartige Möglichkeit eines direkten Vergleichs zwischen malignen Melanomen mit primärer Entstehung im immunprivilegierten Auge (Ziliarkörper-und Aderhautmelanom) und malignen Melanomen mit Entstehung in nicht immunprivilegierten Bereichen des Auges (Bindehautmelanom). Das menschliche Auge ist mit Ausnahme der extraokulären Konjunktiva physiologisch frei von Lymphgefäßen, was einer der wichtigsten Gründe für das "Immunprivileg des Auges" ist [11][12][13][14][15][16]. Die Lymphangiogenese gilt als Risikofaktor für die Metastasierung extraokulärer Melanome [22].…”

Section: Lymphangiogenese Und Immunzellinfiltration Beim Okulären Melunclassified

Neue adjuvante Therapien beim okulären Melanom

Bosch

Heindl

2017

Klin Monatsbl Augenheilkd

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Malignant melanoma is the most common cancer of the eye in adults that originates either in the intra-ocular uveal tract or extra-ocular conjunctiva. Although the primary tumor can be treated successfully, no effective therapy for both metastatic conjunctival and uveal melanoma currently exits. Tumor-associated lymphangiogenesis and immune cell infiltration play a pivotal role in the development and therapeutic targeting of metastases. Here, we provide an overview of current translational research on lymphangiogenesis and its therapeutic inhibition as well as modulation of immune cell infiltration by passive and active immunotherapy in melanoma of the eye. Specifically, our previous and ongoing work on lymphangiogenesis and immune cells in ocular melanoma within the clinical research unit FOR 2240 "(Lymph)Angiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye" is summarized. Translational research on the modulation of tumor-associated lymphangiogenesis and immune cell infiltration could provide novel targets for adjuvant therapy in melanoma of the eye.

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“…Авторы сделали заключение, что шлеммов канал отличается от типичных лимфатических сосудов отсутствием экспрессии LYVE-1 [36]. Не было обнаружено лимфатических сосудов в склере глаза человека, хотя выявлялись отдельные LYVE-1+ клетки, в первую очередь в эписклере [37,38].…”

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Lymphatic system of the eye

et al. 2018

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Existence of lymphatic outflow of intraocular fluid is still an open question. Identification of the lymphatic capillaries and vessels in various human organs in normal and pathological conditions became possible with discovery of endotheliocyte markers for lymphatic vessels. However, the available information on the presence of lymphatic structures in the human eye is inconsistent and uncertain. The data on lymphatic drainage of the eye is of interest, particularly because it may help understand glaucoma pathogenesis, mechanisms of development of eye inflammatory diseases, and develop pathogenetic therapies. The article reviews literature and presents the authors' own views on lymphatic drainage of the human eye.

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Absence of lymphatic vessels in the developing human sclera

Cited by 29 publications

References 31 publications

Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: What can we learn from the eye?

Antilymphangiogenic therapy to promote transplant survival and to reduce cancer metastasis: What can we learn from the eye?

Neue adjuvante Therapien beim okulären Melanom

Lymphatic system of the eye

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