Absence of Borrelia burgdorferi in the myocardium of subjects with normal left ventricular systolic function: a study using PCR and electron microscopy

Kuchynka, Petr; Paleček, Tomáš; Grus, Tomáš; Lindner, Jaroslav; Berenová, Dagmar; Kurzová, Zuzana; P, Balátová; Krsek, Daniel; Vítková, Ivana; Nemecek, Eduard; Podzimkova, Jana; Danek, Barbara A.; Linhart, Aleš

doi:10.5507/bp.2015.051

Cited by 4 publications

(6 citation statements)

References 21 publications

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“…Twenty-three articles reported seroprevalence of LB in seven Eastern European countries ( Table 1 ) (Bazovska et al 2005 , Rojko et al 2005 , Hajek et al 2006 , Biletska et al 2008 , Cisak et al 2008 , Buczek et al 2009 , Bazovská et al 2010 , Podsiadly et al 2011 , Lakos et al 2012 , Machcińska et al 2013 , Kocbach and Kocbach 2014 , Tokarska-Rodak et al 2014 , Zákutná et al 2015a , 2015b , Kuchynka et al 2016 , Magnaval et al 2016 , Zając et al 2017 , Bura et al 2018 , Bušová et al 2018 , Kiewra et al 2018 , Kříž et al 2018 , Pańczuk et al 2019 , Pawelczyk et al 2019 ). National seroprevalence estimates using a single-tier testing strategy on healthy persons and/or indoor workers were 5% in Poland (ELISA IgG, healthy blood donors) (Pawelczyk et al 2019 ), 9.7% in Slovenia (ELISA IgG) (Rojko et al 2005 ), 10.3% in Russia (ELISA IgG) (Magnaval et al 2016 ), and 34.3% in Ukraine (IFA IgG+IgM) (Biletska et al 2008 ).…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of Lyme Borreliosis in Europe: Results from a Systematic Literature Review (2005–2020)

Burn¹,

Pilz

Vyse

et al. 2023

Vector-Borne and Zoonotic Diseases

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Background: Lyme borreliosis (LB), a tick bite-transmitted infection caused by Borrelia burgdorferi sensu lato ( Bbsl ) complex spirochetes, is the most common tickborne disease in Europe. Studies in European countries have reported LB seroprevalence (prevalence of antibodies to Bbsl infection) and diagnostic strategies used for testing. We conducted a systematic literature review to summarize contemporary LB seroprevalence in Europe. Methods: PubMed, Embase, and CABI Direct (Global Health) databases were searched from 2005 to 2020 to identify studies reporting LB seroprevalence in European countries. Reported single-tier and two-tier test results were summarized; algorithms (standard or modified) were used to interpret final test results from studies that used two-tier testing. Results: The search yielded 61 articles from 22 European countries. Studies used a range of diagnostic testing methods and strategies (48% single-tier, 46% standard two-tier, and 6% modified two-tier). In 39 population-based studies, of which 14 were nationally representative, seroprevalence estimates ranged from 2.7% (Norway) to 20% (Finland). There was substantial heterogeneity among studies in terms of design, cohort types, periods sampled, sample sizes, and diagnostics, which limited cross-study comparisons. Nevertheless, among studies that reported seroprevalence in persons with greater exposure to ticks, LB seroprevalence was higher among these groups than in the general population (40.6% vs. 3.9%). Furthermore, among studies that used two-tier testing, general population LB seroprevalence was higher in Western Europe (13.6%) and Eastern Europe (11.1%) than in Northern Europe (4.2%) and Southern Europe (3.9%). Conclusion: Despite variations in LB seroprevalence between and within European subregions and countries, high seroprevalence was observed in certain geographic regions and particular risk groups, suggesting significant disease burden and supporting the need for improved, targeted public health interventions such as vaccination. Harmonized approaches to serologic testing and more nationally representative seroprevalence studies are needed to better understand the prevalence of Bbsl infection in Europe.

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Section: Resultsmentioning

confidence: 99%

Seroprevalence of Lyme Borreliosis in Europe: Results from a Systematic Literature Review (2005–2020)

Burn¹,

Pilz

Vyse

et al. 2023

Vector-Borne and Zoonotic Diseases

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“…In regions that are highly endemic for LD, a high seroprevalence of specific antibodies is present in the general population, and its relevance to clinical disease has been questionable. LD is primarily a clinical diagnosis, and serological analysis is, thus, supportive in the diagnostic process [21]. Antibiotic therapy can be used even without waiting for antibody test results in patients with new-onset AF with high-degree AV block in endemic regions for LC, which may even prevent the need for an implantable pacemaker for these patients [7,[18][19].…”

Section: Discussionmentioning

confidence: 99%

“…LD is primarily a clinical diagnosis; serological analysis is, thus, supportive in the diagnostic process [21]. Confirmation of the presence of this disease is often difficult.…”

Section: Limitationsmentioning

confidence: 99%

“…Confirmation of the presence of this disease is often difficult. morphologically intact spirochetes were readily observed in affected heart sections by immunohistochemistry, even with negative culture results, in patients with confirmed LC who died from sudden cardiac failure [13,21]. Moreover, false-negative results may occur in the early phase of the disease, which does not exclude the diagnosis.…”

Section: Limitationsmentioning

confidence: 99%

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The association between the acquisition of antibodies against Lyme disease and the risk of atrial arrhythmias

Hasiec¹,

Wolny²,

Duda³

et al. 2022

Polish Archives of Internal Medicine

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“…Non-viral infections as the cause of myocarditis are uncommon in our region, although in some endemic areas of the Czech Republic, Borrelia burgorferi is relatively often detected in recent onset dilated cardiomyopathy (RODCM) (ref. [18][19][20] ). Other possible causes of myocarditis are autoimmune or toxic factors.…”

Section: Introductionmentioning

confidence: 99%

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Krejčí¹,

Hude²,

Ozábalová³

et al. 2016

BIOMED PAP

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, Lenka Spinarova aAims. To compare the differences between patients with inflammatory cardiomyopathy (ICM) with and without improvement in left ventricular (LV) systolic function and to identify the relevant predictors of LV improvement. Patients and Methods. The study included 63 patients with biopsy-proven ICM and heart failure symptoms of at least NYHA II, symptom duration ≤ 6 months, LV ejection fraction (LVEF) ≤ 40% assessed by echocardiography and presence of >14 mononuclear leukocytes (LCA+ cells)/mm 2 in biopsy samples. Patients were evaluated at baseline and after 6 months. Results. In the group with LVEF improvement of ≥ 10% (I+ group, n = 41), LVEF increased from 24 ± 7% to 47 ± 8% (P < 0.001). In 22 patients (group I-), there was no or minimal LVEF increase (< 10%). In the I+ group, there were more LCA+ cells/mm 2 at baseline (25.1 ± 16.5 vs. 18.5 ± 4.4 cells/mm 2 ; P = 0.032) and a more significant decrease in LCA+ cells in the follow-up (reduction of 13.6 ± 14.3 cells/mm 2 vs. 5.0 ± 7.7 cells/mm 2 in the I-group; P = 0.009). The univariate logistic regression showed a possible association of number of LCA+ cells, LV end-diastolic diameter and N-terminal fragment of pro-brain natriuretic peptide (NTproBNP) value with LVEF improvement. In the multivariate analysis, only NTproBNP at diagnosis was confirmed as an independent predictor of LVEF improvement (OR=1.2; 1.003 to 1.394; P = 0.046). Conclusion. The LV systolic function improvement was observed in 65% of the patients. In these patients, the number of inflammatory cells at baseline was higher and decreased more but the higher baseline NTproBNP value was the only independent predictor of LVEF improvement.

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Absence of Borrelia burgdorferi in the myocardium of subjects with normal left ventricular systolic function: a study using PCR and electron microscopy

Cited by 4 publications

References 21 publications

Seroprevalence of Lyme Borreliosis in Europe: Results from a Systematic Literature Review (2005–2020)

Seroprevalence of Lyme Borreliosis in Europe: Results from a Systematic Literature Review (2005–2020)

The association between the acquisition of antibodies against Lyme disease and the risk of atrial arrhythmias

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

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