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Eosinophilic myocarditis (EM) represents a rare form of myocardial inflammation with very heterogeneous aetiology. In developed countries, the most prevalent causes of EM are hypersensitivity or allergic reactions, as well as hematological diseases leading to eosinophilia. The disease may have a variable clinical presentation, ranging from asymptomatic forms to life-threatening conditions. Most patients with EM have marked eosinophilia in peripheral blood. Endomyocardial biopsy needs to be performed in most cases in order to establish a definitive diagnosis of EM. The therapy depends on the underlying aetiology. Immunosuppressive therapy represents the treatment mainstay in the majority of EM forms.
Srdeční amyloidóza je charakteristická klinicky významnou extracelulární depozicí amyloidu v srdečních tkáních, která bývá obvykle doprovázena i postižením dalších orgánů v závislosti na konkrétním typu amyloidového proteinu. Srdeční postižení je nejdůležitějším prognostickým faktorem přežívání nemocných, a to především s AL amyloidózou. Časná diagnostika srdeční amyloidózy je tak zcela zásadní pro volbu dalšího terapeutického postupu. Tento přehledový článek si klade za cíl informovat podrobně o patogenezi, projevech a metodách diagnostiky srdeční amyloidózy. Zároveň uvádí přehled současných terapeutických možností, které mají velký potenciál zlepšit dosud poměrně špatnou prognózu postižených jedinců.
Objectives-Fabry disease is an X-linked disorder resulting from ␣-galactosidase A deficiency. The cardiovascular findings include left ventricular hypertrophy (LVH) and increased intima-media thickness of the common carotid artery (CCA IMT). The current study examined the possible correlation between these parameters.
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