Absence of Antidiuresis during Administration of Prostaglandin F2 

Abstract

Water diuresis was induced in six patients in mid-pregnancy. Three were then given oxytocin and the remainder prostaglandin F(2)alpha (PGF(2)alpha), both drugs being infused intravenously in doses used to induce labour at term. Pronounced antidiuresis occurred with oxytocin, whereas PGF(2)alpha showed no such effect. The probable absence of any risk of water intoxication when using PGF(2)alpha in inducing labour may be of particular value when maternal pre-eclampsia or renal disease is present.

Uterine Hypertonus during Labour Induced by Prostaglandins

“…Prostaglandins have the advantage that they do not cause antidiuresis, unlike oxytocin (Roberts et al, 1970), and they are also extremely effective within a much narrower dose range. On the other hand, a minor disadvantage of prostaglandin 705 infusion has been the constant development of what appears to be an "inflammatory reaction" in the arm vein.…”

THE USE OF PROSTAGLANDIN E2 IN THE MANAGEMENT OF INTRAUTERINE DEATH, MISSED ABORTION AND HYDATIDIFORM MOLE

“…Side effects associated with a high dose oxytocin infusion include severe cutaneous vasoconstriction, hypertension and water intoxication associated with its anti-diuretic effect (Roberts et al, 1970). However the main disadvantage is that the induction-abortion interval sometimes extends into days and some patients fail to abort.…”

Termination of Pregnancy with Intra-amniotic Hypertonic Saline

“…The infusion regimen adopted involved a rapid increase in dosage of oxytocin up to a maximum of 100 units per pint (176 units per litre). The infusion was maintained for only 10-12 hours at a time in order to avoid the complication of water intoxication (Roberts et al, 1970). Intramuscular ergometrine 0.5 mg was given after the delivery of the fetus.…”