Absence of anti-single-stranded DNA antibodies in vulvar lichen sclerosus et atrophicus

Non‐Infective Cutaneous Conditions of the Vulva

“…Classical morphoea tends to be firmer, with a violaceous halo, and resolves to leave brownish areas. Shono et al (1991) showed some differences in the lectin staining patterns between the two, and Hacker (1994) found single-stranded DNA antibodies in many examples of morphoea but in none of (vulval) lichen sclerosus. Patterson and Ackerman (1984) concluded that the conditions were distinct, favouring as criteria for the diagnosis of lichen sclerosus a vacuolar change at the dermal-epidermal junction and a lichenoid lymphocytic infiltrate beneath the papillary dermis, whereas in (extragenital) morphoea the subcutis and reticular dermis show sclerosis and inflammatory infiltration.…”

Clinical review of 202 patients with vulval lichen sclerosus: A possible association with psoriasis

“…Other skin diseases included urticaria (5), vulval lichen planus (5, one of whom also had cutaneous lichen planus), morphoea (4) and vitiligo (3). None reported alopecia areata.…”

“…[1][2][3] The British Guidelines for the Management of Lichen Sclerosus recommend a screen for other autoimmune diseases, in particular thyroid disease in women. 4 This study has two major aims: to quantify any possible association between psoriasis and vulval lichen sclerosus; and to evaluate rates of response in the study population to potent topical corticosteroids, previously shown to be very effective.…”