Abridged geriatric assessment is a better predictor of overall survival than the Karnofsky Performance Scale and Physical Performance Test in elderly patients with cancer

Ghosn, Marwan; Ibrahim, Tony; Rassy, Elie El; Nassani, Najib; Ghanem, Sassine; Assi, Tarek

doi:10.1016/j.jgo.2016.11.002

Cited by 28 publications

(19 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies evaluating CGAs typically focus on factors such as functional status, cognitive abilities, emotional conditions, comorbid conditions, nutritional status, polypharmacy and environmental situation (51). Standard oncologic evaluations such as the Eastern Cooperative Oncology Group (ECOG) scale and the Karnofsky Performance Scale (KPS) have been noted to poorly predict treatment-related complications in elderly patients (52). In a study by Ghosn et al, an abridged geriatric assessment, incorporating the factors listed above, performed better than the Karnofsky Performance Scale (KPS) and the Physical Performance Test (PPT) in predicting mortality in elderly patients with cancer (52).…”

Section: Preventionmentioning

confidence: 99%

“…Standard oncologic evaluations such as the Eastern Cooperative Oncology Group (ECOG) scale and the Karnofsky Performance Scale (KPS) have been noted to poorly predict treatment-related complications in elderly patients (52). In a study by Ghosn et al, an abridged geriatric assessment, incorporating the factors listed above, performed better than the Karnofsky Performance Scale (KPS) and the Physical Performance Test (PPT) in predicting mortality in elderly patients with cancer (52). In a recent consensus statement, the International Society of Geriatric Oncology has recommended incorporating the factors listed above into routine geriatric assessments, but did not find sufficient evidence to recommend any one particular CGA (53).…”

Section: Preventionmentioning

confidence: 99%

See 1 more Smart Citation

Cardio-oncology in the older adult

Reddy

Shenoy

Blaes

2017

Journal of Geriatric Oncology

View full text Add to dashboard Cite

Heart disease and cancer are the leading causes of death in older adults. Many first-line cancer treatments have the potential for cardiotoxicity. Age-related risk factors, pre-existing cardiac disease, and a high prevalence of comorbidities are reasons for increased cardiotoxicity in older adults. Concerns regarding cardiotoxicity may lead to frailty bias and undertreatment, resulting in suboptimal outcomes. There is an urgent need for geriatric-specific evidence and guidelines to help tailor care for this vulnerable group. A multi-disciplinary approach based on close collaboration between oncologists, cardiologists, and geriatricians, among other specialist clinicians is essential.

show abstract

Section: Preventionmentioning

confidence: 99%

Section: Preventionmentioning

confidence: 99%

Cardio-oncology in the older adult

Reddy

Shenoy

Blaes

2017

Journal of Geriatric Oncology

View full text Add to dashboard Cite

show abstract

“…Nessa mesma linha de estudo, Ghosn et al 37 identificaram que a avaliação geriátrica é capaz de prever a mortalidade de pacientes idosos com câncer, denotando a relevância da aplicabilidade dessa ferramenta na oncogeriatria.…”

Section: Santos Et Alunclassified

Perfil clínico-epidemiológico de idosos submetidos à quimioterapia antineoplásica atendidos em um hospital de referência oncológica do estado do Pará, Brasil

Santos¹,

Souza²,

Santos³

et al. 2017

Revista Pan-Amazônica de Saúde

View full text Add to dashboard Cite

Perfil clínico-epidemiológico de idosos submetidos à quimioterapia antineoplásica atendidos em um hospital de referência oncológica do estado do Pará, Brasil MATERIALS AND METHODS:A cross-sectional study involving 200 elderly people was performed from April to October, 2015. A socioeconomic and clinical questionnaire was applied and statistical analyses were done afterwards. RESULTS: The prevalence was 60-80 years old (83.5%); no gender predominance; low schooling -82.5% of the participants had finished the elementary school; low family income, from them 79.5% had a family income less than three minimum wages, and 87.5% participating actively in family income; and 57.0% were married or were in stable union. The most common cancer type was breast cancer (26.5%), followed by prostate cancer (17.0%); and the most prevalent anti-neoplasic or adjuvant treatments were bisphosphonate and alkylating agent. CONCLUSION: This study demonstrated the elderly patients profile receiving anti-neoplasic treatment at an oncological reference unit in the North of Brazil, predominating individuals with other comorbidities besides neoplasm, which increases the risks of complications and adverse reactions related to the chemotherapy.

show abstract

“…Aging is defined as a deterioration in physiological function that occurs over time [ 8 ]. Individuals with similar chronological age often vary in their functional age [ 9 ]. Adults with SCD demonstrate substantial and early deterioration of multiple organ systems that leads to complications seen frequently in geriatric populations, such as cardiopulmonary disease, sensory deficits, and a decline in physical and cognitive function [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study

Oyedeji

Hall

Luciano³

et al. 2020

Pilot Feasibility Stud

View full text Add to dashboard Cite

Background The life expectancy for people with sickle cell disease (SCD) has improved tremendously over the last 50 years. This population experiences hemolysis and vaso-occlusion in multiple organs that lead to complications such as cardiopulmonary disease, strokes, and avascular necrosis. These complications can limit mobility and aerobic endurance, similar to limitations that often occur in geriatric populations. These sickle-cell and age-related events lead to frequent hospitalization, which further increases the risk of functional decline. We have few tools to measure functional decline in people with SCD. The purpose of this paper is to describe a protocol to evaluate the feasibility of sickle cell disease geriatric assessment (SCD-GA). Methods/design We will enroll 40 adults with SCD (20 age 18–49.99 years and 20 age ≥ 50 years) in a prospective cohort study to assess the feasibility of SCD-GA. The SCD-GA includes validated measures from the oncology geriatric assessment enriched with additional physical and cognitive measures. The SCD-GA will be performed at the first study visit, at 10 to 20 days after hospitalization, and at 12 months (exit visit). With input from a multidisciplinary team of sickle cell specialists, geriatricians, and experts in physical function and physical activity, we selected assessments across 7 domains: functional status (11 measures), comorbid medical conditions (1 measure), psychological state (1 measure), social support (2 measures), weight status (2 measures), cognition (3 measures), and medications (1 measure). We will measure the proportion completing the assessment with feasibility as the primary outcome. Secondary outcomes include the proportion consenting and completing all study visits, duration of the assessment, acceptability, and adverse events. Discussion We present the protocol and rationale for selection of the measures included in SCD-GA. We also outline the methods to determine feasibility and subsequently to optimize the SCD-GA in preparation for a larger multicenter validation study of the SCD-GA.

show abstract

Abridged geriatric assessment is a better predictor of overall survival than the Karnofsky Performance Scale and Physical Performance Test in elderly patients with cancer

Cited by 28 publications

References 54 publications

Cardio-oncology in the older adult

Cardio-oncology in the older adult

Perfil clínico-epidemiológico de idosos submetidos à quimioterapia antineoplásica atendidos em um hospital de referência oncológica do estado do Pará, Brasil

Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study

Contact Info

Product

Resources

About