2017
DOI: 10.1016/j.jgo.2017.04.001
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Cardio-oncology in the older adult

Abstract: Heart disease and cancer are the leading causes of death in older adults. Many first-line cancer treatments have the potential for cardiotoxicity. Age-related risk factors, pre-existing cardiac disease, and a high prevalence of comorbidities are reasons for increased cardiotoxicity in older adults. Concerns regarding cardiotoxicity may lead to frailty bias and undertreatment, resulting in suboptimal outcomes. There is an urgent need for geriatric-specific evidence and guidelines to help tailor care for this vu… Show more

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Cited by 27 publications
(20 citation statements)
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“…Anthracyclines are also first-line chemotherapeutic agents to treat multiple cancers most commonly observed in older adults-breast and prostate cancer and non-Hodgkin's lymphoma. 169,170 Furthermore, the American Society of Clinical Oncology estimates approximately two to seven-fold increased risk of CVD in older adults (≥60 years of age) undergoing anthracycline chemotherapy when compared to young adults undergoing similar treatment. 171 Accordingly, the combination of advancing age and chemotherapy treatment may be a "double hit" to the vasculature.…”
Section: Anthracycline Chemotherapy In Older Adults: a "Double Hit" To The Vasculaturementioning
confidence: 99%
“…Anthracyclines are also first-line chemotherapeutic agents to treat multiple cancers most commonly observed in older adults-breast and prostate cancer and non-Hodgkin's lymphoma. 169,170 Furthermore, the American Society of Clinical Oncology estimates approximately two to seven-fold increased risk of CVD in older adults (≥60 years of age) undergoing anthracycline chemotherapy when compared to young adults undergoing similar treatment. 171 Accordingly, the combination of advancing age and chemotherapy treatment may be a "double hit" to the vasculature.…”
Section: Anthracycline Chemotherapy In Older Adults: a "Double Hit" To The Vasculaturementioning
confidence: 99%
“…This subsequently leads to the decrease of myocardial volume, which is correlated to increased CV events. 37,38 It has also been shown that pharmacokinetics of anthracyclines alter during aging, resulting in significant increased doxorubicin concentrations, particularly evident in the heart. 39,40…”
Section: Risk Factors For Cardiotoxicitymentioning
confidence: 99%
“…48 In elderly cancer patients, the risk factors of cardiotoxicity can be recapitulated as a “snowball effect”, as described by Reddy et al: the diagnosis of cancer in combination with age-related factors forms the snowball, the cancer treatment and toxicity effects on peripheral tissues enlarge the snowball and set it in motion, to cause CV morbidity and mortality, eventually. 38…”
Section: Risk Factors For Cardiotoxicitymentioning
confidence: 99%
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