About the hypnozoites of the vivax-like group of plasmodia

Corradetti, A.

doi:10.1016/0035-9203(85)90153-1

Cited by 6 publications

(3 citation statements)

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“…The meanings in relation to human malaria of the terms recrudescence, recurrence, and relapse have, historically, been the subject of academic debate (Bruce-Chwatt 1984;Markus 1984;Corradetti 1985;Krotoski 1985). Current usage of these three words is outlined in a publication by the World Health Organization (2010).…”

Section: Hypnozoites and "Relapse" In Human Malariamentioning

confidence: 98%

The hypnozoite concept, with particular reference to malaria

Markus

2010

Parasitol Res

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In 1978, the nature of the hypnozoite was discussed in an article that appeared in a relatively obscure journal, which is also where the term was adopted for Plasmodium (a little-known fact). As a result, that commentary on the use of the word "hypnozoite" has been almost completely overlooked. Although the publication is now more than three decades old, the analysis remains valid today. It is explained in the present paper that like "merozoite" and "sporozoite", the name "hypnozoite" is applicable not only to a latent stage in the life cycle of Plasmodium but to some apparently dormant forms of other kinds of apicomplexan parasites as well. Merozoites of different genera of parasitic protozoa are not necessarily the same biologically and/or otherwise. Similarly, although the hypnozoite concept relates primarily to pre-merozoite stages, some atypical post-divisional apicomplexan forms might also be hypnozoites. Examples are likewise given of latent organisms that, in contrast, are clearly not hypnozoites, such as dormant merozoites in malaria infections. Lastly, the plasmodial hypnozoite is placed in context in relation to the relatively unfamiliar (nomenclaturally) malarial bradysporozoite, chronozoite, dormozoite, merophore, merosome and x body. This paper is based on a presentation by the author, as a Life Member of the American Society of Tropical Medicine and Hygiene, to its 59th Annual Meeting in Atlanta, Georgia, USA, 3-7 November 2010.

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Section: Hypnozoites and "Relapse" In Human Malariamentioning

confidence: 98%

The hypnozoite concept, with particular reference to malaria

Markus

2010

Parasitol Res

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“…Compte tenu de la spécificité des sérums utilisés, de la taille des hypnozoïtes par rapport aux mérozoïtes, de la différence morphologique existant entre sporozoïtes et hypnozoïtes, et de la présence d'hypnozoïtes dès j3, alors que les schizontes exoérythrocytaires n'avaient pas encore atteint leur maturité, il était difficile de prendre en compte les réser-ves faites par Shortt puis Corradetti concernant une éven-tuelle confusion entre hypnozoïtes et microsporidies de moustiques, ou hypnozoïtes et mérozoïtes issus de schizontes exoérythrocytaires [64], ou encore hypnozoïtes et sporozoïtes [18].…”

Section: à La Recherche Des Formes Latentesunclassified

Cycle exoérythrocytaire asexué des plasmodiums humains : une découverte laborieuse

Pays

2010

Bull. Soc. Pathol. Exot.

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“…It is difficult to explain these phenomena by a simple cyclic merogony mechanism. 5,6 Additional work is needed to determine the biomolecular mechanisms envolved in the establishment and activation of hypnozoites and elucidation of true relapse.…”

Section: Introductionmentioning

confidence: 99%