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Lanzkowsky, Philip; Lipton, Jeffrey M.; Fish, Jonathan D.

doi:10.1016/b978-0-12-801368-7.00044-2

Cited by 27 publications

(47 citation statements)

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“…In the literature, EBV positivity was also reported in DLBCL patients 19,20 . In this study, EBV positivity was detected only in three of five cases (60%) in DLBCL patients.…”

Section: Discussionmentioning

confidence: 99%

“…In some non-BL NHL patients, there are high anti-EBV-VCA titers. In addition, unlike the endemic cases, EBV genome could only be shown in tumor tissues of patients who developed ataxia telangiectasia, X-linked lymphoproliferative syndrome and B-cell lymphoma following organ transplantation 20,21 . Ebstein barr vırus positivity in childhood group for BL differs depending on the country, however, the ratios reported were between 34-80%.…”

Section: Discussionmentioning

confidence: 99%

“…Significant differences were detected between the association of EBV with endemic (African type) and sporadic BL. While higher antibody titers against EBV was found in 80-90% of endemic BL patients, this ratio was around 15-20% in sporadic BL patients [18][19][20][21][22][23][24] . In some non-BL NHL patients, there are high anti-EBV-VCA titers.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, the excess of B-cell lymphoma in Brazil attracts attention. The studies conducted show the role of EBV [19][20][21] . The majority of the studies conducted with EBV in NHL intended to analyze the EBV prevalence in BL and to present the impact of the virus in this lymphoma type.…”

Section: Discussionmentioning

confidence: 99%

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Pediatrik lenfomalarda histopatolojik subtip ve Ebstein-Barr virus ilişkisi: immünohistokimyasal ve in situ hibridizasyon çalışması

Bağır

Acikalin

Ergïn

et al. 2018

Cukurova Medical Journal

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AbstractÖz Purpose: The aim of this study was toexplore the histopathologic subtypes of pediatric lymphomas and their relation with Ebstein-Barr virus infection in our region. Materials and Methods:In this retrospective study, 87 children including 36 cases with Hodgkin lymphoma and 51 cases with non-Hodgkin lymphoma were included in the study. The pathologic slides were used to investigate immunohistochemical staining with ebstein-barr virüs latent membrane protein-1 and in-situ hybridization. Results:The most common histopathological subtype in hodgkin lymphoma cases was mixed cellular classical hodgkin lymphoma (55.6%). The most common histopathological subtype in Non-Hodgkin lymphoma cases was Burkitt lymphoma (51.0%). Ebstein-Barr virüs latent membrane protein-1 was positive in 29 Hodgkin lymphoma. All non-Hodgkin lymphoma cases were stained negative with ımmunohistochemical. The positive staining rate of Hodgkin lymphoma cases with in-situ hybridization was 83.3% and this rate was 27.5% in nonHodgkin lymphoma cases. The differences between groups for both staining methods were significant. Conclusion:The results of this study show that the distribution of histopatholojik subtypes of pediatric lymphomas similar to in developing countries. And we have observed that in-situ hybridization is more specific than immunohistochemistry because Ebstein-Barr virus positivity is more detected in in-situ hybridization.Amaç: Bu çalışmanın amacı bölgemizdeki pediatrik lenfomaların histopatolojik alt tiplerinin oranını ve bunların Ebstein-Barr virüs enfeksiyonu ile olan ilişkisini incelemektir. Gereç ve Yöntem: Hodgkin lenfoma tanısı alan 36 olgu ve non-hodgkin lenfoma tanısı alan 51 olgu retrospektif arşiv taraması yapılarak çalışmaya dahil edildi. Olgulara immünohistokimyasal olarak Ebstein-Barr virüs latent membran proteini-1 ve in-situ hibridizasyon uygulandı. Bulgular: Hodgkin lenfoma olgularında; en sık rastlanan histopatolojik alt tipler sırası ile mikst sellüler klasik hodgkin lenfoma (%55,6) idi. Non-Hodgkin lenfoma olgularında en sık rastlanan histopatolojik alt tip Burkitt lenfoma (%51) idi. Ebstein-Barr virüs latent membran proteini-1 ile 29 hodgkin lenfoma olgusunda pozitif iken non-hodgkin lenfoma olgularında immünohistokimya ile pozitif boyanma saptanmadı. Hodgkin lenfoma olgularında in situ hibridizasyon ile boyanma oranı % 83.,3 iken nonHodgkin lenfoma olgularında bu oran % 27.5 idi.. Her iki boyama yöntemi için gruplar arasındaki fark istatistiksel olarak anlamlıydı. Sonuç: Bu çalışmada, olgularımızın histopatolojik dağılımlarının gelişmekte olan ülkelerdeki pediatrik lenfoma olguları ile benzer olduğunu göstermektedir. Aynı zamanda in situ hibridizasyon'da Ebstein-Barr virüs pozitifliği daha fazla olması nedeniyle in situ hibridizasyonun ebstein barr virüs tespitinde immünohistokimyadan daha spesifik olduğunu düşünmekteyiz.

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“…In the literature, EBV positivity was also reported in DLBCL patients 19,20 . In this study, EBV positivity was detected only in three of five cases (60%) in DLBCL patients.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pediatrik lenfomalarda histopatolojik subtip ve Ebstein-Barr virus ilişkisi: immünohistokimyasal ve in situ hibridizasyon çalışması

Bağır

Acikalin

Ergïn

et al. 2018

Cukurova Medical Journal

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“…In XLP cases, the most common clinical manifestation is fulminant infectious mononucleosis (frequency: 58%, survival: 4%). Death is generally attributable to liver failure with hepatic encephalopathy or bone marrow failure with fatal hemorrhages in various organs [ 5 ]. The only curative treatment of XLP is hematopoietic stem cell transplantation [ 6 ].…”

Section: To the Editormentioning

confidence: 99%

First report of an SH2D1A mutation associated with X-linked lymphoproliferative disease in Turkey

Kesici

Keskin

Chiang

et al. 2018

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The survival of childhood leukemia: An 8‐year single‐center experience

et al. 2023

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Background The survival of childhood leukemia has improved. We aimed to report the survival rate and the associated factors in children with acute leukemia during an 8‐year follow‐up. Aims This study investigates the 8‐year survival rates of children with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in Shiraz, the largest oncology center in Southern Iran. We also aimed to assess the independent factors associated with higher mortality in childhood leukemia. Methods Children 0–18 years with acute leukemia were followed from 2013 to 2021 in Shiraz, Iran. The 8‐year overall survival (OS) and event‐free survival (EFS) rates were estimated by the Kaplan–Meier method. Independent factors associated with survival were assessed by the Cox regression hazard modeling. Results We included 786 children, with 43.5% female, and a mean age of 6.32 ± 4.62 years. Patients with AML compared to ALL experienced more relapse (34.6% vs. 22.5%, p = .01) and death (31.7% vs. 11.3%, p < .001). The cumulative 8‐year OS and EFS were 81% (95% confidence interval (CI), 74.3% to 86.1%) and 68.3% (95% CI, 63.5% to 72.7%) in ALL patients and 63.5% (95% CI, 52.1% to 72.9%) and 43% (95% CI, 33.1% to 52.6%) in AML patients. Multivariable analysis revealed that hepatomegaly (hazard ratio = 4, 95% CI, 1.0 to 22.3, p = .05) was the main independent risk factor of death in ALL patients. No definite risk factor was defined for AML patients. Conclusion The survival of childhood leukemia has recently increased dramatically in low‐middle income countries. Hepatomegaly was introduced as a potential risk factor for lower survival in ALL patients. Further multicenter studies are needed to confirm the validity of this association.

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About the Editors

Cited by 27 publications

References 0 publications

Pediatrik lenfomalarda histopatolojik subtip ve Ebstein-Barr virus ilişkisi: immünohistokimyasal ve in situ hibridizasyon çalışması

Pediatrik lenfomalarda histopatolojik subtip ve Ebstein-Barr virus ilişkisi: immünohistokimyasal ve in situ hibridizasyon çalışması

First report of an SH2D1A mutation associated with X-linked lymphoproliferative disease in Turkey

The survival of childhood leukemia: An 8‐year single‐center experience

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