About hazard and risk assessment: Regulatory approaches in assessing safety in the European Union chemicals legislation

Gebel, Thomas; Lechtenberg-Auffarth, E.; Guhe, Christine

doi:10.1016/j.reprotox.2009.03.015

Cited by 10 publications

(4 citation statements)

References 12 publications

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“…This is mainly due to the different chemical environments or substituents that were introduced in the design of the studied compounds. Toxicity results indicate that three of the synthesized compounds (4a, 4b and 4c) would be considered as non-toxic chemicals based on the European Union criteria 52 for the classification…”

Section: Discussionmentioning

confidence: 99%

Molecular design and QSAR study of low acute toxicity biocides with 4,4′-dimorpholyl-methane core obtained by microwave-assisted synthesis

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Molecular design and QSAR study of low acute toxicity biocides with 4,4′-dimorpholyl-methane core obtained by microwave-assisted synthesis

et al. 2010

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“…Perceptions of cyber threats, effectiveness of threat detection mechanisms, implementation of prevention strategies, and cyber risk management practices collectively contribute to a better understanding of the cybersecurity landscape. Identification and analysis of cybersecurity hazards are critical to effectively allocate resources and determine the effectiveness of existing protections [32]. A thorough analysis of cyber incidents and vulnerabilities can provide insights into trends, patterns and common causes, such as human error, that can inform risk management planning and improve cybersecurity [33].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Threat Detection, Prevention Strategies, and Cyber Risk Management for Computer Network Security in Government Information Systems in Indonesia

Judijanto,

Rahardian,

Muthmainah

et al. 2023

WSIST

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This research investigates the landscape of threat detection, prevention strategies, and cyber risk management within Government Information Systems in Indonesia. A quantitative approach, employing Structural Equation Modeling - Partial Least Squares (SEM-PLS), was utilized to analyze data collected from 150 participants across diverse government institutions. The study assessed perceived cyber threats, the effectiveness of threat detection mechanisms, prevention strategy implementation, and cyber risk management practices. Findings revealed significant regional variations in threat perception and underscored the importance of both technological and human-centric approaches. The Structural Equation Model demonstrated satisfactory fit, with notable path coefficients indicating strong relationships among latent variables. The study contributes valuable insights to cybersecurity practices in the Indonesian government sector, informing policymakers and practitioners on strategies to enhance network security resilience.

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“…Other studies, especially multi-generation ones, are required to explain clinical implications of this phenomenon [9,36,37]. An additional evaluation of specific placental hormones and proteins [30,38] will be also desirable for the future human risk assessment [9,30,36,37,39,40]. Histological placental examination seems to be important scientific procedure, especially in cases the organ weight and fetal abnormalities are revealed.…”

Section: Discussionmentioning

confidence: 99%

Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

Burdan

Szumiło²,

Korobowicz-Markiewicz³

et al. 2010

Folia Histochem Cytobiol.

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Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thickness of basal and labyrinth layer, immunoexpression of COX isoenzymes were examined, and confronted with maternal biochemical data and fetal developmental parameters. Higher maternal urea level, as well as lower placental weight and labyrinth thickness were found in the group of fetuses who revealed expression of genes coded the selected interleukins, when compared with the xenobiotic-exposed pups without the selected genes expression and untreated control. A significant correlation between placental weight and maternal total protein or urea level was revealed. Histological changes like inflammatory infiltration and calcification were observed sporadically. Location and intensity of COX-1 staining was similar in all cases. However, more intense COX-2 staining for majority of cells of the basal zone and in dispersed giant cells of the labyrinth was found in inflamed organs. It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level.

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About hazard and risk assessment: Regulatory approaches in assessing safety in the European Union chemicals legislation

Cited by 10 publications

References 12 publications

Molecular design and QSAR study of low acute toxicity biocides with 4,4′-dimorpholyl-methane core obtained by microwave-assisted synthesis

Molecular design and QSAR study of low acute toxicity biocides with 4,4′-dimorpholyl-methane core obtained by microwave-assisted synthesis

Analysis of Threat Detection, Prevention Strategies, and Cyber Risk Management for Computer Network Security in Government Information Systems in Indonesia

Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

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