Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

Burdan, Franciszek; Szumiło, Justyna; Korobowicz-Markiewicz, Agnieszka; Dyndor, Katarzyna; Szumiło, Michał; Klepacz, Robert

doi:10.2478/v10042-008-0097-1

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Some studies indicate that smoking is not a factor exclusively responsible for forming calcium deposits in the placenta, and the consumption of vitamin supplements probably also involves calcification of placental tissues. 5 Recently, interleukins 1 and 6, which are immunity-related cytokines, were identified in placental fluid from placental calcification cases, 6 and Mycoplasma and other organisms were isolated from the placenta after cesarean section. 7 The results indicate that bacterial infections may play an important role in placental calcification.…”

Section: Introductionmentioning

confidence: 99%

Association between calcifying nanoparticles and placental calcification

Guo

Zhang²,

Lü³

et al. 2012

IJN

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Background:The purpose of this study was to examine the possible contribution of calcifying nanoparticles to the pathogenesis of placental calcification. Methods: Calcified placental tissues and distal tissue samples were collected from 36 confirmed placental calcification cases. In addition, 20 normal placental tissue samples were obtained as a control group. All the tissue samples were cultured using special nanobacterial culture methods. The cultured calcifying nanoparticles were examined by transmission electron microscopy (TEM), and their growth was monitored by optical density (OD) at a wavelength of 650 nm. 16S rRNA gene expression of the cultured calcifying nanoparticles was also isolated and sequenced. Results: Novel calcifying nanoparticles wrapped with electron-dense shells between 50 nm to 500 nm in diameter were observed in the extracellular matrix of calcified placental tissues. They were detected in placental villi and hydroxyapatite crystals, and contained "nucleic acidlike materials". After isolation and four weeks of culture, 28 of 36 calcified placental tissue samples showed white granular precipitates attached to the bottom of the culture tubes. OD 650 measurements indicated that the precipitates from the calcified placental tissues were able to grow in culture, whereas no such precipitates from the control tissues were observed. The 16S rRNA genes were isolated from the cultured calcifying nanoparticles and calcified placental tissues, and their gene sequencing results implied that calcifying nanoparticles were novel nanobacteria (GenBank JF823648). Conclusion: Our results suggest that these novel calcifying nanoparticles may play a role in placental calcification.

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Section: Introductionmentioning

confidence: 99%

Association between calcifying nanoparticles and placental calcification

Guo

Zhang²,

Lü³

et al. 2012

IJN

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Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors

Burdan

Starosławska²,

Szumiło

2012

Pharmacological Reports

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Over-the-counter cyclooxygenase inhibitors are used to relief fever and various types of acute pain like headache, toothache, earache, sore throat, as well as postoperative and menstrual ones. They are also major ingredients in cold and flu mixtures. Unlike well-known organ toxicological profile, their prenatal toxicity was not fully established. For a long time, acetaminophen was considered as a relatively safe antipyretic and analgesic drug during pregnancy. However, a new data indicate that it may increase the risk of cryptorchidism and asthma during childhood as well as preeclampsia, preterm birth, maternal phlebothrombosis and pulmonary embolism. Contrary to acetaminophen, non-selective cyclooxygenase inhibitors (non-steroidal anti-inflammatory drugs - NSAID; i.e., diclofenac, ibuprofen, naproxen) may induce intrauterine growth retardation, ductus arteriosus constriction with secondary persistent pulmonary hypertension, reduced fetal renal perfusion that led to oligohydramion, prolonged pregnancy as well as increase prevalence of intracranial bleeding in newborns. Furthermore, a higher risk of miscarriage, stillbirth and some congenital malformations (cardiac and diaphragmatic defects, celosomy - gastroschisis and umbilical hernia) was reported for non-selective inhibitors, in particular high doses of acetylsalicylic acid (aspirin).

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