Abortive or minimal-growth hemangiomas: Immunohistochemical evidence that they represent true infantile hemangiomas

Corella, F.; García-Navarro, Xavier; Ribé, Adriana; Alomar, A.; Baselga, Eulàlia

doi:10.1016/j.jaad.2007.08.007

Cited by 57 publications

(47 citation statements)

References 12 publications

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“…The proximal part exhibiting pebbled patches of bright-red hemangioma and the distal part extending onto the digits had a reticulated network-like telangiectasia morphology. This last morphology had not been described before and in our experience we have not seen the other two morphologies described in IH-MAGs: grouped telangiectasias overlying normal-appearing skin or bluish plaques with normal or a pale peripheral halo [1]. …”

Section: Discussionmentioning

confidence: 76%

“…The hallmarks of IH are their 3 clearly defined stages: they appear in the first weeks of life and undergo a rapid growth phase, followed by a period of slow involution with possible residual lesions [1, 2]. This typical evolution makes them easy to diagnose clinically in most cases.…”

Section: Introductionmentioning

confidence: 99%

“…This typical evolution makes them easy to diagnose clinically in most cases. In addition, IH express an erythrocyte-type glucose transport protein (GLUT-1) in their endothelial cells, which is a highly specific marker of IH [1, 3]. …”

Section: Introductionmentioning

confidence: 99%

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Different Clinical Features of Acral Abortive Hemangiomas

Gutiérrez

Allende

et al. 2017

Case Reports in Dermatological Medicine

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Some infantile hemangiomas called in literature “minimal or arrested growth hemangiomas” or “abortive hemangiomas” are present at birth and have a proliferative component equaling less than 25% of its total surface area. Often, they are mistaken for vascular malformation. We present five patients (three girls and two boys) with abortive hemangiomas diagnosed between January 2010 and December 2015 localized in acral part of the extremities. They were congenital lesions resembling precursor of hemangiomas but did not show proliferation phase. Immunohistochemical Glut-1 was performed in all of them as a way to confirm the abortive hemangioma diagnosis. The most common appearance was a reticulated erythematous patch with multiple fine telangiectasias on the surface. We remark that one of them presented a segmental patch with two different morphologies and evolutions. The proximal part showed pebbled patches of bright-red hemangioma and presented proliferation and the distal part with a reticulated network-like telangiectasia morphology remained unchanged. We detected lower half of the body preference and dorsal region involvement preference without ventral involvement. The ulceration occurred in three patients with two different degrees of severity.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

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Different Clinical Features of Acral Abortive Hemangiomas

Gutiérrez

Allende

et al. 2017

Case Reports in Dermatological Medicine

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“…These IHs are GLUT-1 positive, indicating that they are, indeed, a variant of common IH. 26 Minimally proliferative IHs are more common in the lower body. 26,27 IHs can also be classified as localized, segmental, or indeterminate.…”

Section: Clinical Features Classification and Growth Characteristicsmentioning

confidence: 99%

“…26 Minimally proliferative IHs are more common in the lower body. 26,27 IHs can also be classified as localized, segmental, or indeterminate. 28,29 Localized hemangiomas show spatial containment, as if arising from one central focus ( Figure 1).…”

Section: Clinical Features Classification and Growth Characteristicsmentioning

confidence: 99%

Infantile hemangiomas: from pathogenesis to clinical features

Rosenblatt¹,

Mathes²,

Rosbe

2012

RRN

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Infantile hemangiomas (IH) are benign vascular tumors consisting of a collection of immature cells, including progenitor stem cells and disorganized blood vessels. They are the most common benign tumors in childhood. Recently, there have been significant, exciting advancements in the understanding of the pathogenesis and treatment of infantile hemangiomas, which are discussed in this review. The decision to initiate treatment for IH is based on many factors, including size and location, functional compromise, psychosocial implications, and risks and benefits of the proposed therapy. For most families of children with hemangiomas, education about the natural history of IH and reassurance are often the only "treatment" required. A minority of patients with large, complex lesions or lesions that cause functional compromise require early intervention. These patients and families benefit from a multidisciplinary approach to care in vascular birthmark centers. Ongoing multi-institutional clinical trials will provide further important data on the efficacy and safety of hemangioma treatments.

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Infantile Hemangiomas With Minimal or Arrested Growth

Suh¹,

Frieden²

2010

Arch Dermatol

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Infantile hemangiomas with minimal or arrested growth were defined as infantile hemangiomas with a proliferative component equaling less than 25% of their total surface area. The patients must have been at least age 2 months at the initial visit or on follow-up. Forty-two eligible patients with 47 IH-MAGs were included in the study. Main Outcome Measures: Medical record review was performed for demographic and gestational information, lesion size, and clinical appearance, presence of proliferation, complications, coexisting classic infantile hemangiomas, and morphologic subtype classified as localized, segmental, or indeterminate. Results: Infantile hemangiomas with minimal or arrested growth manifested most commonly as fine or coarse telangiectatic patches. Proliferation was present in 30% (14 of 47 IH-MAGs), usually as small papules at the periphery of these hemangiomas. Sixty-eight percent (32 of 47 IH-MAGs) of them were present on the lower body. Seventeen patients had classic infantile hemangiomas at another body site. Comparison of distribution of sites of IH-MAGs showed a 26-fold (95% confidence interval, 1.9-351.5; P=.01) likelihood of having IH-MAGs on the lower body compared with classic infantile hemangiomas. Conclusions: Infantile hemangiomas with minimal or arrested growth have a distinct clinical appearance and a unique predilection for the lower body. Recognition of IH-MAGs will help in more accurate diagnosis of vascular birthmarks of infancy, and the presence of IH-MAGs in an individual patient does not exclude the proliferative potential of other infantile hemangiomas that may be present.

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Abortive or minimal-growth hemangiomas: Immunohistochemical evidence that they represent true infantile hemangiomas

Cited by 57 publications

References 12 publications

Different Clinical Features of Acral Abortive Hemangiomas

Different Clinical Features of Acral Abortive Hemangiomas

Infantile hemangiomas: from pathogenesis to clinical features

Infantile Hemangiomas With Minimal or Arrested Growth

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