Infantile Hemangiomas With Minimal or Arrested Growth

Abstract

Infantile hemangiomas with minimal or arrested growth were defined as infantile hemangiomas with a proliferative component equaling less than 25% of their total surface area. The patients must have been at least age 2 months at the initial visit or on follow-up. Forty-two eligible patients with 47 IH-MAGs were included in the study. Main Outcome Measures: Medical record review was performed for demographic and gestational information, lesion size, and clinical appearance, presence of proliferation, complications, coexisting classic infantile hemangiomas, and morphologic subtype classified as localized, segmental, or indeterminate. Results: Infantile hemangiomas with minimal or arrested growth manifested most commonly as fine or coarse telangiectatic patches. Proliferation was present in 30% (14 of 47 IH-MAGs), usually as small papules at the periphery of these hemangiomas. Sixty-eight percent (32 of 47 IH-MAGs) of them were present on the lower body. Seventeen patients had classic infantile hemangiomas at another body site. Comparison of distribution of sites of IH-MAGs showed a 26-fold (95% confidence interval, 1.9-351.5; P=.01) likelihood of having IH-MAGs on the lower body compared with classic infantile hemangiomas. Conclusions: Infantile hemangiomas with minimal or arrested growth have a distinct clinical appearance and a unique predilection for the lower body. Recognition of IH-MAGs will help in more accurate diagnosis of vascular birthmarks of infancy, and the presence of IH-MAGs in an individual patient does not exclude the proliferative potential of other infantile hemangiomas that may be present.

Early Growth of Infantile Hemangiomas: What Parents’ Photographs Tell Us

“…Thus, using parental photographs also limited our ability to study early growth characteristics of hemangiomas at other body sites, particularly those involving the lower half of the body, where less vigorous growth is often found. 18 In addition we were unable to collect precise volumetric measurements of hemangiomas, which might have given more quantitative results regarding hemangioma growth. Perhaps the most important limitation is that the majority of our patients had primarily superficial hemangiomas, and the growth characteristics found may be less generalizable to deeper hemangiomas, which can arise later in life and often grow for longer.…”

Beyond infections: tumors and malformations of the diaper area

“…Small vascular papules at the edge of the ulceration may indicate the presence of an incipient or minimal growth infantile hemangioma. 1 Congenital lesions that appear in the lumbosacral area are commonly seen as markers of occult spinal dysraphism, or tethered spinal cord, particularly when more than one anomaly is noted. These lesions will vary and may appear as a mass just under the skin, simple or complex dimple, or as a capillary vascular stain or hemangioma of the lumbosacral region.…”

Hämangiome. Neue Aspekte zu Pathogenese, Differenzialdiagnosen und Therapie

“…Aufgrund seines allen falls geringen Wachstums wird es auch als IHMAG ("infantile haemangioma with minimal or arrested growth") be zeichnet [22]. Vorwiegend an den unte ren Extremitäten zeigen sich ein blasser erythematöser Patch mit retikulärer Ge fäßzeichnung sowie einzelnen erythema tösen Papeln im Randbereich, die einer Proliferation und Regression unterliegen (.…”

“…Im Unter schied zu diesem und zum RICH/NICH ist das retikuläre Hämangiom GLUT1po sitiv. Eine Assoziation mit urogenitalen, neurologischen und kardialen Fehlbil dungen wurde beschrieben [19], scheint jedoch sehr selten zu sein [22]. …”