Abortifacient potential for the epigeal parts of Peganum harmala

Shapira, Zvia; Terkel, Joseph; Egozi, Yaakov; Nyska, A.; Friedman, Jacob E.

doi:10.1016/0378-8741(89)90006-8

Cited by 44 publications

(30 citation statements)

References 8 publications

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“…[7] Although, harmaline and harmine are the most important alkaloids that are generally responsible for their beneficial effects, numerous studies show that other alkaloids present in P. harmala also have some roles in the pharmacological effects of the plant. [8] Harmaline (C 13 H 15 ON 2 ) was first isolated by Göbel from the seeds and roots of P. harmala and is the major alkaloid of this plant. [6] In addition to P. harmala (Harmal), beta-carboline alkaloids are present in many other plants such as Banisteriopsis caapi ( Malpighiaceae ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids

Moloudizargari¹,

Mikaili²,

et al. 2013

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Wild Syrian rue (Peganum harmala L. family Zygophyllaceae) is well-known in Iran and various parts of this plant including, its seeds, bark, and root have been used as folk medicine. Recent years of research has demonstrated different pharmacological and therapeutic effects of P. harmala and its active alkaloids, especially harmine and harmaline. Analytical studies on the chemical composition of the plant show that the most important constituents of this plant are beta-carboline alkaloids such as harmalol, harmaline, and harmine. Harmine is the most studied among these naturally occurring alkaloids. In addition to P. harmala (Syrian rue), these beta-carbolines are present in many other plants such as Banisteria caapi and are used for the treatment of different diseases. This article reviews the traditional uses and pharmacological effects of total extract and individual active alkaloids of P. harmala (Syrian rue).

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Section: Introductionmentioning

confidence: 99%

Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids

Moloudizargari¹,

Mikaili²,

et al. 2013

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“…Although many studies were carried on the cytogenetic effects of many plant extracts (Kumar and Kumar 1972, Kabarity and Malallah 1980, Adams and Rashad 1984, Abderrhman 1998, Shapira et al 1989, Li et al 1995, Abou El Kheir and Abou El Kheir 1992, Omani et al 1996, El Khodary 1980, and some others are still in need for such investigation.…”

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confidence: 99%

Cytogenetic Effects of Calotropis procera Extract on Vicia faba L.

Haroun

Shehri

2001

CYTOLOGIA

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Summary The present investigation study the morphological and cytogenetic effects of Calotropis procera extract on Vicia faba L. The control plants being normal while treated ones are significantly affected. Four concentrations (5, 15, 30, 60%) of this extract were applied for 3 duration time. For treated seeds, low doses caused increase in mitotic indix (MI) and exhibit stimulatory effect on percentage of germination and plant height. On the other hand high concentratiosn gave rise to substantial reduction in MI, percentage of germination and plant height and all were found dose and time dependent. In contrast, all parameters tested for treated roots were found negatively affected with no exception and found more harmful and effective compared to seed treatment experiment. Various types of mitotic and meiotic abnormalities were observed. Their percentage of these abnormalities was also found dose and time dependent. Stickiness type was found more frequent compared with other types. The extract also affect chromosome association during meiosis. Chromosome pairing, chiasma frequency and pollen fertility were found negatively affected and dose dependent. The present data confirm the use of this extract as insect control at high concentrations is harmful to plants as non-target organism. It also recommend the use of lower concentration (15%), which has a significant affect on insect with very low side effects on plants. Key words Calotropis procera extract, Cytogenetic effects, Vicia faba The use of synthetic chemicals for plant protection and their cytogenetic effects have been well documented (Shehab 1980, Mohammed 1986, Badr et al. 1985, Qureshi et al. 1988. No doubt, that most of synthetic chemical used surround the world resulted in disturbances of environment and lethal on non target organisms e.g., plant, animal etc. For these reasons, it has become necessary to search alternative natural compounds for environmental safety.Extracts of many plants have been tested for the above reasons (El Gammal et al. 1988, Nassar 1995, Nassar et al. 1997, Soliman and El Sherif 1995, Mohammed 1986. Although many studies were carried on the cytogenetic effects of many plant extracts (Kumar and Kumar 1972, Kabarity and Malallah 1980, Adams and Rashad 1984, Abderrhman 1998, Shapira et al. 1989, Li et al. 1995, Abou El Kheir and Abou El Kheir 1992, Omani et al. 1996, El Khodary 1980, and some others are still in need for such investigation.Extract of Calotropis procera (Family Asclepiadaceae) has been used as botanical insect growth inhibitor by Nassar (1995) and Giridhar et al. (1984). The extract shows effective results as insecticide at certain concentrations.The aim of this study is to investigate the effect of different concentrations (5, 15, 30, 60%) of this extract on percentage of germination, plant growth and cytogenetic of Vicia faba as non target organism. Parameters measured were plant height, percentage of germination, mitotic index, aberrations and mitotic behaviour.

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“…Quinazoline alkaloids (e.g., vasicine and vasicinone), within P. harmala, have been attributed to the abortifacient effect of this plant [6, 7]. In our case, the ingestion of seeds of P. harmala was in order to provoke abortion, which was realized spontaneously two days later.…”

Section: Discussionmentioning

confidence: 68%

Peganum harmalaL. Intoxication in a Pregnant Woman

Berdaï

Labib

Harandou

2014

Case Reports in Emergency Medicine

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Peganum harmala L. is a plant widely distributed in the Mediterranean region. It is commonly used in traditional medicine in Morocco as sedative and abortifacient but exposes users to the risk of overdose and poisoning. The pharmacologically active compounds of this plant include a number of β-carboline and quinazoline alkaloids responsible of its pharmacological and toxicological effects. We report the case of a 24-year-old woman, 22 weeks pregnant, intoxicated with the seeds of Peganum harmala L. On admission, she had disturbance of consciousness, uterine contraction, and oliguria. Laboratory tests revealed renal failure and liver injury, and she benefited then from hemodialysis. During hospitalization, she was intubated after deterioration of consciousness and presented a spontaneous expulsion of the fetus. After extubation, she kept unusual sequelae: cerebellar ataxia and peripheral polyneuropathy. Physicians in regions using Peganum harmala L. as traditional medicine must be able to detect symptoms of its toxicity, in order to establish early gastrointestinal decontamination. The prognosis of this intoxication is variable; most cases can be managed successfully; but in high doses of intoxication, evolution can be fatal.

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Abortifacient potential for the epigeal parts of Peganum harmala

Cited by 44 publications

References 8 publications

Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids

Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids

Cytogenetic Effects of Calotropis procera Extract on Vicia faba L.

Peganum harmalaL. Intoxication in a Pregnant Woman

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