Abolishment of Alimentary Lipemia Following Injection of Heparin

Triton Hyperlipemia in Dogs

“…On the contrary, Horlick and Duff (28), and Schumaker (29), found no change in serum lipids in cholesterol-fed rabbits treated with heparin. Heparin is believed to clear alimentary lipemia (30) by promoting the release of lipoprotein lipase, a lipolytic enzyme (31,32). This mechanism was used by Day et d. (33) to explain the reduction in serum concentrations of total fatty acids in cholesterol-fed rabbits treated with heparin.…”

Blood Lipids and Human Atherosclerosis

“…Within 15 minutes there was essentially a "wipe-out" of lipoproteins from Sf 20-100, associated with an increase in the concentration of the Sf 1O-20 class. Then, during the next six hours there was an over-all shift within the S f 10-20 class, so that the S f 12-20 lipoproteins were markedly reduced in concentration to below their original level, while the S f 10-12 and S f [6][7][8][9][10] In an effort to determine the effect of a maintained heparin level on the serum lipoprotein pattern we have made some studies of individuals receiving repository heparin. * Figure 2 shows the effect of heparin repository in the same patient whose studies are shown in figure 1 with intravenous heparin.…”

The Use of Hemolysin Inhibition in the Study of Experimental And Clinical Hyperlipemia: THE NON-SPECIFIC INHIBITION OF STREPTOLYSIN O BY SERUM LIPOPROTEINS1

“…The enhancing effect of heparin upon the inhibition of streptolysin 0 by the sera of cholesterol-fed rabbits occurs in the absence of a significant change in this ratio. This effect of heparin may be related to the change in the size of lipoprotein molecules which occurs following injection of this substance (19,33,34). In addition, the diluted sera of rabbits who received Triton WR 1339 intravenously showed inhibition of streptolysin 0 hemolysis even though the cholesterol/phospholipid ratio of such sera was quite low.…”