Blood Lipids and Human Atherosclerosis

Graham, Dean M.; Lyon, Thomas P.; Gofman, John W.; Jones, Hardin B.; Yankley, Alexander; Simonton, John; White, Sidney G.

doi:10.1161/01.cir.4.5.666

Cited by 202 publications

(26 citation statements)

References 9 publications

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“…Heparin is known to cause changes in plasma lipoprotein species opposite to those ascribed to triton in the preceding section, in that its injection causes the disappearance of lipoproteins of high Ss rate (19,20). If, then, triton effects hypercholesteremia by changing the character of plasma lipoproteins so that the plasma is able to bind cholesterol in a form which is not easily available for removal by the liver, then heparin conceivably might counteract this effect by reversing the changes in the lipoprotein spectrum of plasma and allowing cholesterol once again to be removed by the liver.…”

Section: Plasma Lipoprotein Alteration In the Rat After Triton Injectionmentioning

confidence: 92%

The Mechanism Responsible for the Hypercholesteremia Induced by Triton Wr-1339

Friedman

Byers

1953

Journal of Experimental Medicine

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Injection of triton WR-1339 into rats leads to a rapid increase in the cholesterol, cholate, and various lipid fractions of their blood. The increase in cholesterol is confined to the blood itself. The cholesteremic effect of triton was not dependent upon a prior accumulation of cholate in plasma. The liver was found to be the source of the excess cholesterol but the rate of cholesterol synthesis, the excretion of cholate, and the cholesterol content of the liver were not changed by injection of triton. The cholesteremic effect of triton is not due to alteration in the intestinal excretion of cholesterol. Transfer of blood between "tritonized" and normal rats leads to a disappearance of the hypercholesteremia in the former and its appearance in the latter animals. The plasma proteins of rats injected with triton are markedly changed qualitatively. Heparin was found to inhibit the hypercholesteremic effect of triton. The hypercholesteremia following triton injection appears to be due to a fundamental physicochemical change in the plasma proteins produced by injection of this detergent.

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Section: Plasma Lipoprotein Alteration In the Rat After Triton Injectionmentioning

confidence: 92%

The Mechanism Responsible for the Hypercholesteremia Induced by Triton Wr-1339

Friedman

Byers

1953

Journal of Experimental Medicine

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“…It might be expected, therefore, to result in the production of more "lipoproteins" of higher density. Such a droduction on heparin injection was observed by Graham et al [1951] and by Boyle, Bragdon and Brown [1952] in their ultracentrifugal studies in man. The observation of Brown, Boyle and Anfinsen [1953] that non-turbid "lipoproteins" inhibited the clearing of turbid "lipoproteins" by heparinized plasma is, also, in accordance with such a concept, since the non-turbid "lipoproteins" might be expected to compete for the available lipase.…”

mentioning

confidence: 63%

Further Studies on the Interaction of Chyle and Plasma in the Rat

Robinson¹,

Jeffries²,

Poole³

1955

Exp Physiol

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WHEN a rat is absorbing olive oil from its intestine there is a marked increase in the ability of its plasma to clear chyle added to it in vitro [Jeffries, 1954 Further studies made on these clearing systems, demonstrable in vitro after olive oil feeding and after the injection of small quantities of heparin, are reported in this paper. METHODSWistar strain albino rats, fed a laboratory stock diet containing 2 per cent fat, were used. All animals were starved for 16 hours before olive oil was fed or heparin injected. Olive oil was given by stomach tube under light ether anLesthesia. The techniques used for collecting chyle, obtaining plasma and measuring the rate of clearing at 370 C., and the use of the terms clearing and clearing reaction, have been described previously [French, Robinson and Florey, 1953;Robinson et al., 1954]. The plasma of an animal which has received an intravenous injection of heparin has been called heparinized plasma. A quantity of chyle in excess of that which could be cleared by the volume of plasma used was added in all experiments so that, for the experimental conditions defined, maximum initial rates of clearing were measured.

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“…As early as 1951, Graham et al 15) had suggested that a single intravenous injection of heparin to anginal patients relieved angina pectoris in 55 patients out of 59. Engelberg16),17) had reported that heparin reduced 55 % of cases of severe angina by an ballistocardiographic study and the effect might be seen within 6 hours after an administration of heparin, suggesting a possible role of heparin to remove the lipoproteins from an arterial intimal surface.…”

Section: Discussionmentioning

confidence: 99%

The Short-Term Effects of Chondroitin Sulfates A and C on Coronary Atherosclerotic Subjects

et al. 1969

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SUMMARYEffects of a single intravenous injection of chondroitin sulfates A and C on coronary atherosclerotic subjects were studied by using an electrocardiogram and measuring thrombus-formation time and prothrombin time. Improvement of ST and T changes after a single intravenous injection of chondroitin sulfate C was observed in coronary atherosclerotic patients with electrocardiographically appreciable ST depression, being associated with the prolongations of thrombus-formation time and of prothrombin time. These effects were more active in chondroitin sulfate C than in chondroitin sulfate A. Possible ameliorating effects of chondroitin sulfates A and C on coronary atherosclerosis were discussed in relation with their anti-thrombogenic properties.

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Blood Lipids and Human Atherosclerosis

Cited by 202 publications

References 9 publications

The Mechanism Responsible for the Hypercholesteremia Induced by Triton Wr-1339

The Mechanism Responsible for the Hypercholesteremia Induced by Triton Wr-1339

Further Studies on the Interaction of Chyle and Plasma in the Rat

The Short-Term Effects of Chondroitin Sulfates A and C on Coronary Atherosclerotic Subjects

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