ABO blood type correlates with survival in hepatocellular carcinoma following hepatectomy

Abstract

ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B, and 65 (9.4%) had blood group AB. The median OS was 55 months in patients with blood group O, 39 months for blood group A, 34 months for blood group B, and 34 months for blood group AB patients (P = 0.001, log-rank test). There were significant differences in OS between patients with blood groups O and A [hazard ratio (HR) = 1.416; 95% CI, 1.101–1.820; P = 0.007], blood group B (HR = 1.736; 95% CI, 1.333–2.262; P < 0.001), blood group AB (HR = 1.739; 95% CI, 1.210–2.499; P = 0.003) and non-O blood groups (HR = 1.485; 95% CI, 1.204–1.830; P < 0.001). Our constructed nomogram (c-index = 0.687) predicted the prognosis more accurately than the TNM stage alone(c-index = 0.601). In conclusion, non-O blood groups are poor prognostic indicators for HCC following hepatectomy. Our findings justify further external validation in larger cohorts.

Interaction Between Prediabetes and the ABO Blood Types in Predicting Postsurgical Esophageal Squamous Cell Carcinoma-Specific Mortality: The FIESTA Study

“…To the best of our knowledge, this is thus far the first study that has evaluated the prognosis of prediabetes and the ABO blood type for postsurgical ESCC-specific morality. Extending the previous findings on the association of blood type with diabetes mellitus( 27 ) and cancer ( 28 – 30 ), this study highlights the close monitoring of blood glucose at the prediabetes stage in postsurgical ESCC patients, especially with the blood types O and A.…”

Prognostic role of ABO blood group in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

“… 17 Recently, ABO blood group has been reported to correlate with increasing the risk of HCC. 18 , 19 However, few investigations have examined its prognostic role in unresectable HCC patients following TACE. Therefore, we assess the association of ABO blood group and the prognosis of unresectable HCC patients who underwent TACE as an initial treatment in the Chinese population for the first time.…”

Does blood group affect survival following pancreatoduodenectomy for periampullary malignancy?

“…In the short-term, ABO blood group information can be integrated along with other prognostic factors into a predictive tool that stratifies patients according to their risk of recurrence after resection. Such tools can prove to be more discriminative than TNM staging alone, 24 although it is accepted that this will have limited or no clinical impact for the majority of patients.…”